Results 41 to 50 of about 14,644 (161)

Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections

BMC Genomics, 2023
Background RNA editing is a process that increases transcriptome diversity, often through Adenosine Deaminases Acting on RNA (ADARs) that catalyze the deamination of adenosine to inosine.
Benjamin Wales-McGrath, Heather Mercer, Helen Piontkivska   +2 more
doaj   +1 more source

Using participatory scenario planning to explore the synergies and trade‐offs from upland treescape expansion

People and Nature, EarlyView.
Abstract The future of land use in the UK uplands is highly debated, with growing interest in increasing tree cover and other land use changes, alongside a desire to maintain traditional land use patterns and practices. Treescape expansion is likely to result in synergies and trade‐offs between different outcomes, so integrating stakeholder preferences
Melissa Minter, Susan Baker, Euan Bowditch, Sheena Carlisle, Natasha Constant, Alix Syder, Tom Finch   +6 more
wiley   +1 more source

A loss-of-function human ADAR variant activates innate immune response and promotes bowel inflammation

Nature Communications
Inflammatory bowel disease (IBD) arises from genetic-environmental interactions. Adenosine deaminases acting on RNA 1 (ADAR), an RNA-editing enzyme converting adenosine (A) to inosine (I), is essential for tissue homeostasis.
Pengfei Xu, Yue Xi, Jong-Won Kim, Min Zhang, Chen Gao, Yue Wang, Meishu Xu, Xingchen Wang, Songrong Ren, Da Yang, Qingde Wang, Wen Xie   +11 more
doaj   +1 more source

Host‐induced silencing of the Minc09294 effector gene impairs Meloidogyne incognita and M. Enterolobii infection

Pest Management Science, EarlyView.
Host‐induced gene silencing of the effector candidate Minc09294 significantly impairs Meloidogyne incognita parasitism, markedly reducing gall formation, reproduction, and the development of specialized giant cells, with partial cross‐species effects on M.
João Pedro Abreu‐Sousa, Thuanne Pires Ribeiro, Daniele Heloisa Pinheiro, Valdeir Junio Vaz Moreira, Luanna Pinheiro Alburquerque Freitas Bezerra, Júlia Moura Rosário Santana, Lays Antunes Teixeira, Maria Eugenia Lisei‐de‐Sa, Deyse Alexandra Rosero Alpala, Manoely Abreu Reis, Isabela Tristan Lourenço‐Tessutti, Leonardo Lima Pepino Macedo, Carolina Vianna Morgante, Maria Cristina Mattar Silva, Marcos Fernando Basso, Janice de Almeida‐Engler, Maria Fatima Grossi‐de‐Sa   +16 more
wiley   +1 more source

Optimization of triple dye mixture removal by oxidation with Fenton

, 2020
Azo dyes are widely used in textile industry due to their easy production, high stability during washing and variety of colors. It raises concern over the ecosystem because of its structural features.
Adar, Elanur
core   +1 more source

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

8-azaadenosine and 8-chloroadenosine are not selective inhibitors of ADAR [PDF]

, 2021
The RNA editing enzyme ADAR, is an attractive therapeutic target for multiple cancers. Through its deaminase activity, ADAR edits adenosine to inosine in dsRNAs.
Weber, Jason D., Torres, Luisangely Soto, Cottrell, Kyle A, Dizon, Michael G., Cottrell, Kyle A., Dizon, Michael G, Weber, Jason D   +6 more
core   +1 more source

Thermodynamic characterisation of covalent ligand binding

British Journal of Pharmacology, EarlyView.
Background and Purpose Differential scanning fluorimetry (DSF) is a common and straightforward method to evaluate the thermal stability of proteins and has been heavily used for ligand binding characterisation as well as for screening. One class of compounds that is less typically evaluated by DSF are covalent binders.
Rebecca Hertzman, Maayan Lavie, Almog Nadir, Ronen Gabizon, Nir London   +4 more
wiley   +1 more source

Optimization of cattle manure liquid fraction anaerobic digestion at different temperatures: modelling by taguchi method [PDF]

, 2020
In this study, the effect of different parameters (mixing speed, temperature, substrate/inoculation ratio) on the anaerobic digestion of cattle manure liquid fraction was analyzed and optimized with Taguchi method.
Adar, Elanur
core  

Adar contributes to genome integrity by regulating R-loop homeostasis in Drosophila

BMC Biology
Background Adenosine deaminase acting on RNA (Adar) is a critical enzyme involved in post-transcriptional epigenetic regulation through adenosine-to-inosine (A-to-I) RNA editing.
Xuedi Zhang, Hongyun Liu, Ju Peng, Guangbin Wang, Xiangyu Wu, Shuai Li, Jie Zheng, Qianwen Sun, Guanjun Gao   +8 more
doaj   +1 more source