Results 61 to 70 of about 42,435 (206)

ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity. [PDF]

, 2016
It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the
Dickman, DK, Joiner, WJ, Paluch, J, Robinson, JE   +3 more
core  

To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]

, 2015
Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH, MacDonald, Margaret R, Rice, Charles M   +2 more
core   +1 more source

Improving forest age estimation to understand subtropical forest regrowth dynamics using deep learning image segmentation of time‐series historical aerial photographs

Remote Sensing in Ecology and Conservation, EarlyView.
Accurately estimating forest age is key to understanding how forests recover and evaluating restoration success. We developed a two‐step deep learning approach using historical greyscale aerial photographs to map forest age at fine spatial scales. By combining a pre‐trained model with localized fine‐tuning, our U‐Net + ResNet50 architecture achieved ...
Ying Ki Law, Yi‐Fei Gu, Shuwen Liu, Guangqin Song, Aland H. Y. Chan, Cham Man Tse, Zhonghua Liu, Martha J. Ledger, Billy C. H. Hau, Sawaid Abbas, Jin Wu   +10 more
wiley   +1 more source

ADAR mediates differential expression of polycistronic microRNAs [PDF]

Nucleic Acids Research, 2014
Adenosine deaminases acting on RNAs (ADARs) convert adenosine residues to inosines in primary microRNA (pri-miRNA) transcripts to alter the structural conformation of these precursors and the subsequent functions of the encoded microRNAs (miRNAs). Here we show that RNA editing by Drosophila ADAR modulates the expression of three co-transcribed miRNAs ...
Chawla, Geetanjali, Sokol, Nicholas S.
openaire   +2 more sources

Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish.

PLoS Genetics, 2015
Fragile X syndrome (FXS) is the most frequent inherited form of mental retardation. The cause for this X-linked disorder is the silencing of the fragile X mental retardation 1 (fmr1) gene and the absence of the fragile X mental retardation protein (Fmrp).
Adi Shamay-Ramot, Khen Khermesh, Hagit T Porath, Michal Barak, Yishay Pinto, Chaim Wachtel, Alona Zilberberg, Tali Lerer-Goldshtein, Sol Efroni, Erez Y Levanon, Lior Appelbaum   +10 more
doaj   +1 more source

Deep Learning for Link Prediction in Dynamic Networks using Weak Estimators

, 2018
Link prediction is the task of evaluating the probability that an edge exists in a network, and it has useful applications in many domains. Traditional approaches rely on measuring the similarity between two nodes in a static context. Recent research has
Chiu, Carter, Zhan, Justin
core   +1 more source

A preventive strategy for the control of aphids in sweet pepper using lacewings and micrococcinelid beetles

Insect Science, EarlyView.
Aphids pose a serious risk to horticultural crops. Current biocontrol strategies often fail due to the poor establishment of natural enemies when aphids are scarce. We evaluated the potential of two aphidophagous predators, Micromus variegatus and Scymnus interruptus, to be used as preventive biocontrol agents, released before aphid infestation.
Jesica Pérez‐Rodríguez, Reinier T. Valstar, Ada Leman, Gerben J. Messelink   +3 more
wiley   +1 more source

Reliance as Promise

American Business Law Journal, EarlyView.
Abstract In the face of powerful criticism, the “reliance interest” continues to hold an impactful position in judicial and academic treatment of contract damages. And yet, the theoretical foundation of reliance damages for breach of contract remains unsettled.
Yehuda Adar, Efi Zemach
wiley   +1 more source

Altered ADAR 2 equilibrium and 5HT2CR editing in the prefrontal cortex of ADAR 2 transgenic mice [PDF]

Genes, Brain and Behavior, 2011
Modulation of serotonin signaling by RNA editing of the serotonin 2C receptor (5HT(2C) R) may be relevant to affective disorder as serotonin functions regulate mood and behavior. Previously, we observed enhanced endogenous behavioral despair in ADAR2 transgenic mice.
M, Singh, M M, Singh, E, Na, K, Agassandian, M B, Zimmerman, A K, Johnson   +5 more
openaire   +2 more sources

Discriminative Link Prediction using Local Links, Node Features and Community Structure

, 2013
A link prediction (LP) algorithm is given a graph, and has to rank, for each node, other nodes that are candidates for new linkage. LP is strongly motivated by social search and recommendation applications. LP techniques often focus on global properties (
Chakrabarti, Soumen, De, Abir, Ganguly, Niloy   +2 more
core   +1 more source