Results 61 to 70 of about 14,644 (161)

ADAR RNA editing below the backbone

, 2017
ADAR RNA editing enzymes (adenosine deaminases acting on RNA) that convert adenosine bases to inosines were first identified biochemically 30 years ago.
Anzer Khan, Dragana Vukic, Liam Keegan, Mary O'Connell   +3 more
core   +1 more source

Plant cis‐regulatory grammar: Decoding the multidimensional code of transcriptional regulation for programmable crop engineering

Journal of Integrative Plant Biology, EarlyView.
This review decodes the grammar of plant cis‐regulatory elements, revealing that their function emerges from sequence, chromatin accessibility, 3D topology, and cell type context. It highlights how single‐cell omics, CRISPR dissection, and AI‐driven design converge to enable predictive engineering and crop improvement. ABSTRACT Cis‐regulatory elements (
Libin Zhang, Maoteng Li
wiley   +1 more source

ADAR-1 editing and DAg accumulation.

A) Schematic representation of the ADAR-1 locus targeted by the different sgRNAs for KO generation (Upper) and the ADAR-1 isoforms, p110 and p150, including the functional domains for each isoform and the localization of the sgRNAs targeted regions ...
Udo Hetzel (162762), Thomas F. Baumert (15291307), Valérie Courgnaud (18107241), Carine Chavey (369936), Eloi Verrier (5424479), Jussi Hepojoki (410961), Nora Goldmann (18107238), Joe McKellar (10156938), Damien Gregoire (18107244), Jeremy Dufourt (18107235), Dieter Glebe (421759), Pierre Khalfi (7868252), Leonora Szirovicza (18107232), Karim Majzoub (6176003), Giovanni Merolla (18107223), Zoé Denis (13124446), José Ursic-Bedoya (18107226), Kaku Goto (332712), Lena Soppa (18107229), Cedric Leyrat (5656741)   +19 more
core   +1 more source

Phylogenetic and structural analysis of Hydra ADAR [PDF]

Adenosine deaminases acting on RNAs (ADARs) perform adenosine-to-inosine (A-to-I) RNA editing for essential biological functions. While studies of editing sites in diverse animals have revealed unique biological roles of ADAR editing including ...
Mozumder, Sukanya, Beal, Peter A, Venkatesh, Srinidhi, Zhang, Howard, Mah, Jasmine L, Wilcox, Xander E, Juliano, Celina E, Fisher, Andrew J, Cazet, Jack F   +8 more
core   +1 more source

Systematic identification and characterization of high efficiency Cas9 guide RNAs for therapeutic targeting of ADAR.

PLoS ONE
Therapeutic targeting of the adenosine deaminase ADAR has great potential in cancer and other indications; however, it remains unclear what approach can enable effective and selective therapeutic inhibition.
Benjamin G Gowen, Kory Melton, Weng In Leong, Prachi Khekare, Shannon McCawley, Jean Chan, Pierre Boivin, Vihasi Jani, Aaron J Cantor, Akshay Tambe, Mary Haak-Frendscho, Mary J Janatpour, Spencer C Wei   +12 more
doaj   +1 more source

Critical Success Factors for Enhancing the Circular Economy Performance of Last‐Mile Cold Chain Logistics Packaging for Urban Agricultural Products

Business Strategy and the Environment, Volume 35, Issue 6, Page 8646-8671, September 2026.
ABSTRACT With the increasing demand for high‐quality agricultural products, the agricultural cold‐chain logistics packaging (ACLP) industry faces significant environmental pressure and circular economy issues. This study analyzes the critical success factors (CSFs) that would enhance ACLP circular economy performance (CEP). The adversarial interpretive
Miao Su, Chunyu Liu, Shucheng Duan, Taewoo Roh   +3 more
wiley   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, Volume 3, Issue 3, September 2026.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang, Yin Zhu, Fang Xu, Yongjing Liu, Yuan Li, Ling Yuan, Liqin Wei, Bo Huang, Yan Chen, Pei Huang, Zuochen Du   +10 more
wiley   +1 more source

RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley   +1 more source

Robust Machine Learning–Based Ionospheric Delay Grid Modeling for PPP‐RTK Under Sparse Reference Stations and Severe Geomagnetic Disturbance

Space Weather, Volume 24, Issue 9, September 2026.
Abstract Sparse reference station networks and severe geomagnetic disturbances can significantly degrade the accuracy of regional ionospheric delay modeling at the network side, thereby reducing the positioning performance of PPP‐RTK. To address this issue, this study proposes a machine learning‐based ionospheric delay grid modeling method that finely ...
Linyu He, Weiping Jiang, Hua Chen, Xingyu Zhou, Tianjun Liu, Jie He, Jie Ding   +6 more
wiley   +1 more source