Results 71 to 80 of about 8,523 (174)

Post‐transcriptional regulatory networks: The dynamic interplay of RNA‐binding proteins

The FEBS Journal, Volume 293, Issue 12, Page 3423-3441, June 2026.
Post‐transcriptional gene expression regulation is controlled by RNA‐binding proteins (RBPs), which influence many processes including splicing, localization, translation, and decay. Rather than acting alone, RBPs bind RNAs combinatorially, forming complex, context‐dependent regulatory networks.
Lena A. Street, Marko Jovanovic, Eugenio F. Fornasiero   +2 more
wiley   +1 more source

A-to-I editing of Malacoherpesviridae RNAs supports the antiviral role of ADAR1 in mollusks

BMC Evolutionary Biology, 2019
Background Adenosine deaminase enzymes of the ADAR family are conserved in metazoans. They convert adenine into inosine in dsRNAs and thus alter both structural properties and the coding potential of their substrates.
Umberto Rosani, Chang-Ming Bai, Lorenzo Maso, Maxwell Shapiro, Miriam Abbadi, Stefania Domeneghetti, Chong-Ming Wang, Laura Cendron, Thomas MacCarthy, Paola Venier   +9 more
doaj   +1 more source

Atmospheric dust is a global nutrient source for plants via foliar uptake

New Phytologist, Volume 250, Issue 5, Page 2867-2883, June 2026.
Summary Atmospheric mineral dust is a critical nutrient supplier to marine ecosystems, but its role in terrestrial plant nutrition remains underexplored due to the assumption that nutrients are acquired solely from soils via roots. Here, we demonstrate that plants directly acquire nutrients from dust through leaves, revealing an unrecognized ...
Anton Lokshin, Daniel Palchan, Marcelo Sternberg, Tom Goren, Mahdi (André) Nakhavali, Avner Gross   +5 more
wiley   +1 more source

Tripartite motif 47 promotes the development of thyroid carcinoma through ADAR ubiquitination

Molecular Medicine
Background Tripartite motif 47 (TRIM47) plays a vital role in the carcinogenesis and drug resistance of various cancers, whereas the function of TRIM47 in thyroid carcinoma (TC) remains unclear.
Hongzhou Liu, Xiaodong Hu, Tan Li, Yuhan Wang, Xiaomin Fu   +4 more
doaj   +1 more source

Bilateral striatal necrosis caused by ADAR mutations in two siblings with dystonia and freckles-like skin changes that should be differentiated from Leigh syndrome

Folia Neuropathologica, 2016
Pathogenic molecular variants in the ADAR gene are a known cause of rare diseases, autosomal recessive Aicardi- Goutières syndrome type 6, severe infantile encephalopathy with intracranial calcifications and dominant dyschromatosis symmetrica hereditaria,
Dorota Piekutowska-Abramczuk, Hanna Mierzewska, Monika Bekiesińska-Figatowska, Elżbieta Ciara, Joanna Trubicka, Maciej Pronicki, Dariusz Rokicki, Małgorzata Rydzanicz, Rafał Płoski, Ewa Pronicka   +9 more
doaj   +1 more source

Phylogenetic and structural analysis of Hydra ADAR

Archives of Biochemistry and Biophysics
Adenosine deaminases acting on RNAs (ADARs) perform adenosine-to-inosine (A-to-I) RNA editing for essential biological functions. While studies of editing sites in diverse animals have revealed unique biological roles of ADAR editing including temperature adaptation and reproductive maturation, rigorous biochemical and structural studies of these ADARs
Xander E. Wilcox, Howard Zhang, Jasmine L. Mah, Jack F. Cazet, Sukanya Mozumder, Srinidhi Venkatesh, Celina E. Juliano, Peter A. Beal, Andrew J. Fisher   +8 more
openaire   +3 more sources

Evidence for transcriptome-wide RNA editing among Sus scrofa PRE-1 SINE elements

BMC Genomics, 2017
Background RNA editing by ADAR (adenosine deaminase acting on RNA) proteins is a form of transcriptional regulation that is widespread among humans and other primates.
Scott A. Funkhouser, Juan P. Steibel, Ronald O. Bates, Nancy E. Raney, Darius Schenk, Catherine W. Ernst   +5 more
doaj   +1 more source

Charting and probing the activity of ADARs in human development and cell-fate specification

Nature Communications
Adenosine deaminases acting on RNA (ADARs) impact diverse cellular processes and pathological conditions, but their functions in early cell-fate specification remain less understood.
Amir Dailamy, Weiqi Lyu, Sami Nourreddine, Michael Tong, Joseph Rainaldi, Daniella McDonald, Rebecca Panwala, Alysson Muotri, Michael S. Breen, Kun Zhang, Prashant Mali   +10 more
doaj   +1 more source

An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation

Cell Reports
Summary: Adar null mutant mouse embryos die with aberrant double-stranded RNA (dsRNA)-driven interferon induction, and Adar Mavs double mutants, in which interferon induction is prevented, die soon after birth.
Ketty Sinigaglia, Anna Cherian, Qiupei Du, Valentina Lacovich, Dragana Vukić, Janka Melicherová, Pavla Linhartova, Lisa Zerad, Stanislav Stejskal, Radek Malik, Jan Prochazka, Nadège Bondurand, Radislav Sedláček, Mary A. O’Connell, Liam P. Keegan   +14 more
doaj   +1 more source

The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis

eLife, 2017
ADAR proteins alter gene expression both by catalyzing adenosine (A) to inosine (I) RNA editing and binding to regulatory elements in target RNAs. Loss of ADARs affects neuronal function in all animals studied to date.
Sarah N Deffit, Brian A Yee, Aidan C Manning, Suba Rajendren, Pranathi Vadlamani, Emily C Wheeler, Alain Domissy, Michael C Washburn, Gene W Yeo, Heather A Hundley   +9 more
doaj   +1 more source