Results 81 to 90 of about 8,523 (174)
ADARES: Adaptive Resource Management for Virtual Machines
CoRR, 2018 Virtual execution environments allow for consolidation of multiple applications onto the same physical server, thereby enabling more efficient use of server resources. However, users often statically configure the resources of virtual machines through guesswork, resulting in either insufficient resource allocations that hinder VM performance, or ...
Ignacio Cano 0001 +7 more
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ADARs: pleiotropy in function, versatility in application
Nucleic Acids ResearchAbstract RNA processing is essential for proper cellular function, contributing to protein and cell state diversity, and is often dysregulated in diseased states. A key subset of RNA regulators is the double-stranded RNA-specific adenosine deaminase (ADAR) protein family, which hydrolytically deaminates double-stranded RNA, causing an ...
Yifan Zhang +3 more
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Annals of Indian Academy of Neurology, 2019 Aicardi–Goutières syndrome (AGS) is a rare, genetic inflammatory disease due to mutations in any of the seven genes discovered to date (TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1).
Debopam Samanta, Raghu Ramakrishnaiah
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Pediatric Rheumatology Online JournalBackground Aicardi-Goutières Syndrome is a monogenic type 1 interferonopathy with infantile onset, characterized by a variable degree of neurological damage.
Alba Gabaldon-Albero +12 more
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Scientific ReportsThe APOBEC/AID family is known for its mutator activity, and recent evidence also supports the potential impact of ADARs. Furthermore, the mutator impacts of APOBEC/ADAR mutations have not yet been investigated.
Ahmadreza Niavarani
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ADARs regulate cuticle collagen expression and promote survival to pathogen infection
BMC BiologyBackground In all organisms, the innate immune system defends against pathogens through basal expression of molecules that provide critical barriers to invasion and inducible expression of effectors that combat infection. The adenosine deaminase that act
Alfa Dhakal +5 more
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ADAR Therapeutics as a New Tool for Personalized Medicine
GenesIn the field of RNA therapy, innovative approaches based on adenosine deaminases acting on RNA (ADAR)-mediated site-directed RNA editing (SDRE) have been established, providing an exciting opportunity for RNA therapeutics. ADAR1 and ADAR2 enzymes are accountable for the predominant form of RNA editing in humans, which involves the hydrolytic ...
Bertoli M., La Via L., Barbon A.
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Nature CommunicationsCustom RNA base editing exploiting the human Adenosine Deaminase Acting on RNA (ADAR) enzyme may enable therapeutic gene editing without DNA damage or use of foreign proteins.
Susan M. Byrne +10 more
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