Results 21 to 30 of about 8,523 (174)

ADAR expression and copy number variation in patients with advanced gastric cancer

BMC Gastroenterology, 2020
Background Gastric cancer (GC) is a world health problem and it is the third leading cause of cancer deaths worldwide. The current practice for prognosis assessment in GC is based on radiological and pathological criteria and they may not result in an ...
Javad Behroozi, Shirin Shahbazi, Mohammad Reza Bakhtiarizadeh, Habibollah Mahmoodzadeh   +3 more
doaj   +1 more source

The A to I editing landscape in melanoma and its relation to clinical outcome

RNA Biology, 2022
RNA editing refers to non-transient RNA modifications that occur after transcription and prior to translation by the ribosomes. RNA editing is more widespread in cancer cells than in non-transformed cells and is associated with tumorigenesis of various ...
Austeja Amweg, Marina Tusup, Phil Cheng, Ernesto Picardi, Reinhard Dummer, Mitchell P Levesque, Lars E French, Emmanuella Guenova, Severin Läuchli, Thomas Kundig, Mark Mellett, Steve Pascolo   +11 more
doaj   +1 more source

Dynamic hyper-editing underlies temperature adaptation in Drosophila. [PDF]

PLoS Genetics, 2017
In Drosophila, A-to-I editing is prevalent in the brain, and mutations in the editing enzyme ADAR correlate with specific behavioral defects. Here we demonstrate a role for ADAR in behavioral temperature adaptation in Drosophila.
Ilana Buchumenski, Osnat Bartok, Reut Ashwal-Fluss, Varun Pandey, Hagit T Porath, Erez Y Levanon, Sebastian Kadener   +6 more
doaj   +1 more source

Programmable RNA editing with endogenous ADAR enzymes – a feasible option for the treatment of inherited retinal disease?

Frontiers in Molecular Neuroscience, 2023
RNA editing holds great promise for the therapeutic correction of pathogenic, single nucleotide variants (SNV) in the human transcriptome since it does not risk creating permanent off-targets edits in the genome and has the potential for innovative ...
Julia-Sophia Bellingrath, Michelle E. McClements, M. Dominik Fischer, M. Dominik Fischer, Robert E. MacLaren, Robert E. MacLaren   +5 more
doaj   +1 more source

Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

BMC Biology, 2020
Background In fly brains, the Drosophila Adar (adenosine deaminase acting on RNA) enzyme edits hundreds of transcripts to generate edited isoforms of encoded proteins.
Anzer Khan, Simona Paro, Leeanne McGurk, Nagraj Sambrani, Marion C. Hogg, James Brindle, Giuseppa Pennetta, Liam P. Keegan, Mary A. O’Connell   +8 more
doaj   +1 more source

ADAR Expression and Single Nucleotide Variants in Multiple Sclerosis Patients Affect the Response to Interferon Beta Therapy

Global Medical Genetics, 2023
Interferon (IFN)-β is the first-line disease management choice in multiple sclerosis (MS) with profound effects; however, in up to 50% of patients, clinical response does not occur.
Fakhr Fakhr, Shaygannejad Shaygannejad, Khorrami Khorrami, Saberi Saberi, Mirmosayyeb Mirmosayyeb, Sadeghi Sadeghi, Kheirollahi Kheirollahi   +6 more
doaj   +1 more source

Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome

Cell Reports, 2015
Little is known about how RNA editing operates in cancer. Transcriptome analysis of 68 normal and cancerous breast tissues revealed that the editing enzyme ADAR acts uniformly, on the same loci, across tissues.
Debora Fumagalli, David Gacquer, Françoise Rothé, Anne Lefort, Frederick Libert, David Brown, Naima Kheddoumi, Adam Shlien, Tomasz Konopka, Roberto Salgado, Denis Larsimont, Kornelia Polyak, Karen Willard-Gallo, Christine Desmedt, Martine Piccart, Marc Abramowicz, Peter J. Campbell, Christos Sotiriou, Vincent Detours   +18 more
doaj   +1 more source

RNA Editing-Dependent and -Independent Roles of Adenosine Deaminases Acting on RNA Proteins in Herpesvirus Infection—Hints on Another Layer of Complexity

Viruses, 2023
The Adenosine Deaminases Acting on RNA (ADAR) catalyze the posttranscriptional deamination of adenosine residues to inosine in double-stranded RNAs (dsRNAs, A-to-I editing), preventing the overactivation of dsRNA sensor molecules and interferons.
Vlatka Ivanišević, Lidia Žilić, Marina Čunko, Hana Fadiga, Ivana Munitić, Igor Jurak   +5 more
doaj   +1 more source

Adar is essential for optimal presynaptic function [PDF]

Molecular and Cellular Neuroscience, 2013
RNA editing is a powerful way to recode genetic information. Because it potentially affects RNA targets that are predominantly present in neurons, it is widely hypothesized to affect neuronal structure and physiology. Across phyla, loss of the enzyme responsible for RNA editing, Adar, leads to behavioral changes, impaired locomotion, neurodegeneration ...
Carolina, Maldonado, Daniel, Alicea, Maryvi, Gonzalez, Maria, Bykhovskaia, Bruno, Marie   +4 more
openaire   +2 more sources

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins

Biomolecules, 2015
The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Niamh Mannion, Fabiana Arieti, Angela Gallo, Liam P. Keegan, Mary A. O'Connell   +4 more
doaj   +1 more source