Results 31 to 40 of about 2,808,906 (291)

Publica aut peri! The Releasing and Distribution of Roman Books [PDF]

, 2007
This outline of our knowledge of the process of releasing literature in late republican and early imperial Rome addresses the nature of the recitations, the question of ‘publishing’ and distribution of books, from Atticus to Pliny the Younger.
Jon Wikene Iddeng
core   +1 more source

Increased A-to-I RNA editing in atherosclerosis and cardiomyopathies

PLOS Computational Biology, 2023
Adenosine-to-inosine RNA editing is essential to prevent undesired immune activation. This diverse process alters the genetic content of the RNA and may recode proteins, change splice sites and miRNA targets, and mimic genomic mutations. Recent studies have associated or implicated aberrant editing with pathological conditions, including cancer ...
Tomer D. Mann, Eli Kopel, Eli Eisenberg, Erez Y. Levanon   +3 more
openaire   +4 more sources

Systematically Characterizing A-to-I RNA Editing Neoantigens in Cancer [PDF]

Frontiers in Oncology, 2020
A-to-I RNA editing can contribute to the transcriptomic and proteomic diversity of many diseases including cancer. It has been reported that peptides generated from RNA editing could be naturally presented by human leukocyte antigen (HLA) molecules and elicit CD8+ T cell activation.
Chi Zhou, Zhiting Wei, Liye Zhang, Zhaoyi Yang, Qi Liu   +4 more
openaire   +3 more sources

Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections

BMC Genomics, 2023
Background RNA editing is a process that increases transcriptome diversity, often through Adenosine Deaminases Acting on RNA (ADARs) that catalyze the deamination of adenosine to inosine.
Benjamin Wales-McGrath, Heather Mercer, Helen Piontkivska   +2 more
doaj   +1 more source

Transcriptome analysis identification of A-to-I RNA editing in granulosa cells associated with PCOS

Frontiers in Endocrinology, 2023
BackgroundPolycystic ovary syndrome (PCOS) is a complex, multifactor disorder in women of reproductive age worldwide. Although RNA editing may contribute to a variety of diseases, its role in PCOS remains unclear.MethodsA discovery RNA-Seq dataset was ...
Fan-Sheng Kong, Fan-Sheng Kong, Zijing Lu, Zijing Lu, Yuan Zhou, Yuan Zhou, Yinghua Lu, Chun-Yan Ren, Ruofan Jia, Ruofan Jia, Beilei Zeng, Beilei Zeng, Panwang Huang, Panwang Huang, Jihong Wang, Yaping Ma, Yaping Ma, Jian-Huan Chen, Jian-Huan Chen, Jian-Huan Chen   +19 more
doaj   +1 more source

EndoVIA for quantifying A-to-I editing and mapping the subcellular localization of edited transcripts. [PDF]

Methods Enzymol
Adenosine-to-inosine (A-to-I) editing, catalyzed by adenosine deaminases acting on RNA (ADARs), is a prevalent post-transcriptional modification that is vital for numerous biological functions. Given that this modification impacts global gene expression, RNA localization, and innate cellular immunity, dysregulation of A-to-I editing has unsurprisingly ...
Quillin AL, Arnould B, Knutson SD, Flores TF, Heemstra JM.   +4 more
europepmc   +3 more sources

Do RNA modifications contribute to modulation of immune responses in allergic diseases?

Frontiers in Allergy, 2023
RNA modifications have emerged as a fundamental mechanism of post-transcriptional gene regulation, playing vital roles in cellular physiology and the development of various diseases.
Pavel Kudrin, Ana Rebane
doaj   +1 more source

Transcriptome-wide identification of A > I RNA editing sites by inosine specific cleavage [PDF]

, 2013
Adenosine to inosine (A > I) RNA editing, which is catalyzed by the ADAR family of proteins, is one of the fundamental mechanisms by which transcriptomic diversity is generated.
Cattenoz, Pierre B., Mattick, John S., Taft, Ryan J., Westhof, Eric   +3 more
core   +2 more sources

The contribution of Alu exons to the human proteome. [PDF]

, 2016
BackgroundAlu elements are major contributors to lineage-specific new exons in primate and human genomes. Recent studies indicate that some Alu exons have high transcript inclusion levels or tissue-specific splicing profiles, and may play important ...
Jiang, Peng, Lam, Maggie PY, Lin, Lan, Lu, Zhi-Xiang, Park, Juw Won, Ping, Peipei, Wang, Jinkai, Xing, Yi   +7 more
core   +1 more source

A-to-I RNA editing – thinking beyond the single nucleotide [PDF]

RNA Biology, 2017
Adenosine-to-inosine RNA editing is a conserved process, which is performed by ADAR enzymes. By changing nucleotides in coding regions of genes and altering codons, ADARs expand the cell's protein repertoire. This function of the ADAR enzymes is essential for human brain development. However, most of the known editing sites are in non-coding repetitive
Nabeel S. Ganem, Ayelet T. Lamm
openaire   +2 more sources