Results 11 to 20 of about 2,808,906 (291)
A-to-I RNA Editing in Cancer: From Evaluating the Editing Level to Exploring the Editing Effects [PDF]
Frontiers in Oncology, 2021 As an important regulatory mechanism at the posttranscriptional level in metazoans, adenosine deaminase acting on RNA (ADAR)-induced A-to-I RNA editing modification of double-stranded RNA has been widely detected and reported.
Heming Wang +9 more
doaj +3 more sources
Advances in A-to-I RNA editing in cancer
Molecular CancerRNA modifications are widespread throughout the mammalian transcriptome and play pivotal roles in regulating various cellular processes. These modifications are strongly linked to the development of many cancers.
Yi Zhang +9 more
doaj +3 more sources
Knowledge in the Investigation of A-to-I RNA editing signals [PDF]
Frontiers in Bioengineering and Biotechnology, 2015 RNA editing is a post-transcriptional alteration of RNA sequences that is able to affect protein structure as well as RNA and protein expression. A-to-I (Adenosine-to-Inosine) RNA editing is the most frequent and common post-transcriptional modification ...
Giovanni eNigita +4 more
doaj +3 more sources
The cell line A-to-I RNA editing catalogue [PDF]
Nucleic Acids Research, 2020 Abstract Adenosine-to-inosine (A-to-I) RNA editing is a common post transcriptional modification. It has a critical role in protecting against false activation of innate immunity by endogenous double stranded RNAs and has been associated with various regulatory processes and diseases such as autoimmune and cardiovascular diseases as well
Eli Eisenberg +5 more
openaire +3 more sources
Substitutional A‐to‐I RNA editing [PDF]
WIREs RNA, 2010 AbstractAdenosine‐to‐inosine (A‐to‐I) editing catalyzed by adenosine deaminases acting on RNA (ADARs) entails the chemical conversion of adenosine residues to inosine residues within double‐stranded RNA (dsRNA) substrates. Inosine base pairs as guanosine and A‐to‐I editing can therefore alter the structure and base pairing properties of the RNA ...
Bjorn-Erik, Wulff, Kazuko, Nishikura
openaire +2 more sources
Detecting and Characterizing A-To-I microRNA Editing in Cancer [PDF]
Cancers, 2021 Adenosine to inosine (A-to-I) editing consists of an RNA modification where single adenosines along the RNA sequence are converted into inosines. Such a biochemical transformation is catalyzed by enzymes belonging to the family of adenosine deaminases acting on RNA (ADARs) and occurs either co- or post-transcriptionally.
Gioacchino P. Marceca +5 more
openaire +2 more sources
Molecular Cancer, 2021 Background Adenosine deaminases acting on RNA (ADARs) modify many cellular RNAs by catalyzing the conversion of adenosine to inosine (A-to-I), and their deregulation is associated with several cancers.
Julia Ramírez-Moya +5 more
doaj +1 more source
N6-Methyladenosines Modulate A-to-I RNA Editing [PDF]
Molecular Cell, 2018 N6-methyladenosine (m6A) and adenosine-to-inosine (A-to-I) editing are two of the most abundant RNA modifications, both at adenosines. Yet, the interaction of these two types of adenosine modifications is largely unknown. Here we show a global A-to-I difference between m6A-positive and m6A-negative RNA populations.
Jian-Feng, Xiang +5 more
openaire +2 more sources
A-to-I RNA Editing and Human Disease [PDF]
RNA Biology, 2006 The post-transcriptional modification of mammalian transcripts by A-to-I RNA editing has been recognized as an important mechanism for the generation of molecular diversity and also regulates protein function through recoding of genomic information.
Stefan, Maas +3 more
openaire +2 more sources
L-GIREMI uncovers RNA editing sites in long-read RNA-seq
Genome Biology, 2023 Although long-read RNA-seq is increasingly applied to characterize full-length transcripts it can also enable detection of nucleotide variants, such as genetic mutations or RNA editing sites, which is significantly under-explored.
Zhiheng Liu +7 more
doaj +1 more source