Results 41 to 50 of about 2,808,906 (291)

An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization

Cells, 2019
Therapeutic neovascularization can facilitate blood flow recovery in patients with ischemic cardiovascular disease, the leading cause of death worldwide.
Reginald V.C.T. van der Kwast, Paul H.A. Quax, A. Yaël Nossent   +2 more
doaj   +1 more source

Activity-regulated RNA editing in select neuronal subfields in hippocampus [PDF]

, 2012
RNA editing by adensosine deaminases is a widespread mechanism to alter genetic information in metazoa. In addition to modifications in non-coding regions, editing contributes to diversification of protein function, in analogy to alternative splicing ...
Ales Balik, Altschul, Andrew C. Penn, Aruscavage, Bass, Birney, Bratt, Brorson, Coleman, Coleman, Daniel, Darty, Dawson, de la Mata, Feldmeyer, Feng, Fisahn, Gahwiler, Gainey, Gallo, Ge, Goodman, Greger, Greger, Greger, Gurevich, Hamada, Hideyama, Hideyama, Higuchi, Higuchi, Hoopengardner, Hundley, Ingo H. Greger, Jepson, Katoh, Kent, Lee, Lein, Li, Liu, Lomeli, Maas, Marcucci, Palladino, Paul, Peng, Peng, Penn, Penn, Penn, Pozo, Rosenthal, Rueter, Ryman, Sanjana, Schoft, Seeburg, Seeburg, Sommer, Sommer, Stefl, Stefl, Tariq, Toth, Traynelis, Turrigiano, Turrigiano, Valente, Venkatesh, Wang, Witter, Xie, Zsofia Nemoda   +73 more
core   +1 more source

Kinetic proofreading at single molecular level: Aminoacylation of tRNA^{Ile} and the role of water as an editor [PDF]

, 2013
Proofreading/editing in protein synthesis is essential for accurate translation of information from the genetic code. In this article we present a theoretical investigation of efficiency of a kinetic proofreading mechanism that employs hydrolysis of the ...
Bagchi, Biman, Santra, Mantu
core   +6 more sources

A-to-I mRNA Editing in a Ferric Siderophore Receptor Improves Competition for Iron in Xanthomonas oryzae pv. oryzicola

Microbiology Spectrum, 2021
Iron is an essential element for the growth and survival of pathogenic bacteria; however, it is not fully understood how bacteria sense and respond to iron deficiency or excess. In this study, we show that xfeA in Xanthomonas oryzae pv.
Wenhan Nie, Sai Wang, Jin Huang, Qin Xu, Peihong Wang, Yan Wu, Rui He, Ayizekeranmu Yiming, Jingling Liang, Iftikhar Ahmad, Luoyi Fu, Longbiao Guo, Junhua Yuan, Bo Zhu, Gongyou Chen   +14 more
doaj   +1 more source

A-to-I RNA editing in the earliest-diverging Eumetazoan phyla [PDF]

, 2017
© The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Biology and Evolution 34 (2017): 1890-1901, doi:10.1093/molbev/msx125.The highly conserved ...
Alon, Shahar, Eisenberg, Eli, Kaniewska, Paulina, Levanon, Erez, Levy, Oren, Porath, Hagit T., Rosenthal, Joshua J. C., Schaffer, Amos A.   +7 more
core   +1 more source

Type-Directed Program Transformations for the Working Functional Programmer [PDF]

, 2020
We present preliminary research on Deuce+, a set of tools integrating plain text editing with structural manipulation that brings the power of expressive and extensible type-directed program transformations to everyday, working programmers without a ...
Chugh, Ravi, Lubin, Justin
core   +1 more source

Altered A-to-I RNA Editing in Human Embryogenesis

PLoS ONE, 2012
Post-transcriptional events play an important role in human development. The question arises as to whether Adenosine to Inosine RNA editing, catalyzed by the ADAR (Adenosine Deaminase acting on RNA) enzymes, differs in human embryogenesis and in adulthood.
Ronit Shtrichman, Igal Germanguz, Rachel Mandel, Anna Ziskind, Irit Nahor, Michal Safran, Sivan Osenberg, Ofra Sherf, Gideon Rechavi, Joseph Itskovitz-Eldor   +9 more
openaire   +4 more sources

A-to-I editing of the 5HT2C receptor and behaviour [PDF]

Briefings in Functional Genomics and Proteomics, 2006
Site-specific deamination of five adenosine residues in the pre-mRNA of the serotonin 2C receptor, 5HT2CR, alters the amino acid sequence of the encoded protein. Such RNA editing can produce 32 mRNA variants, encoding 24 protein isoforms that vary in biochemical and pharmacological properties.
Katheleen, Gardiner, Yunzhi, Du
openaire   +2 more sources

Recommendations for detection, validation, and evaluation of RNA editing events in cardiovascular and neurological/neurodegenerative diseases

Molecular Therapy: Nucleic Acids
RNA editing, a common and potentially highly functional form of RNA modification, encompasses two different RNA modifications, namely adenosine to inosine (A-to-I) and cytidine to uridine (C-to-U) editing. As inosines are interpreted as guanosines by the
Korina Karagianni, Alessia Bibi, Alisia Madé, Shubhra Acharya, Mikko Parkkonen, Teodora Barbalata, Prashant K. Srivastava, David de Gonzalo-Calvo, Constanza Emanueli, Fabio Martelli, Yvan Devaux, Dimitra Dafou, A. Yaël Nossent   +12 more
doaj   +1 more source

Harnessing the Potential of Human Pluripotent Stem Cells and Gene Editing for the Treatment of Retinal Degeneration [PDF]

, 2017
PURPOSE OF REVIEW: A major cause of visual disorders is dysfunction and/or loss of the light-sensitive cells of the retina, the photoreceptors. To develop better treatments for patients, we need to understand how inherited retinal disease mutations ...
Ali, RR, Georgiadis, A, Ovando-Roche, P, Pearson, RA, Smith, AJ   +4 more
core   +1 more source