Results 51 to 60 of about 2,808,906 (291)

A-to-I RNA editing and hematopoiesis

Experimental Hematology
Adenosine-to-inosine (A-to-I) RNA editing plays essential roles in modulating normal development and homeostasis. This process is catalyzed by adenosine deaminase acting on RNA (ADAR) family proteins. The most well-understood biological processes modulated by A-to-I editing are innate immunity and neurological development, attributed to ADAR1 and ADAR2,
Zhen, Liang, Carl R, Walkley, Jacki E, Heraud-Farlow   +2 more
openaire   +2 more sources

Adaptation of A-to-I RNA editing in Drosophila

PLOS Genetics, 2017
Adenosine-to-inosine (A-to-I) editing is hypothesized to facilitate adaptive evolution by expanding proteomic diversity through an epigenetic approach. However, it is challenging to provide evidences to support this hypothesis at the whole editome level.
Yuange Duan, Shengqian Dou, Shiqi Luo, Hong Zhang, Jian Lu   +4 more
openaire   +4 more sources

Expressional Localization and Functionally Identifying an RNA Editing Enzyme BmADARa of the Silkworm Bombyx mori

Insects, 2020
The most common type of RNA editing in metazoans is the deamination of adenosine into inosine (A-to-I) catalyzed by the adenosine deaminase acting on the RNA (ADAR) family of proteins.
Chongjun Ye, Song Jiang, Meixia Gong, Qin Min, Manli Fan, Junshan Gao, Yan Meng   +6 more
doaj   +1 more source

The dynamic epitranscriptome: A to I editing modulates genetic information. [PDF]

Chromosoma, 2016
Adenosine to inosine editing (A to I editing) is a cotranscriptional process that contributes to transcriptome complexity by deamination of adenosines to inosines. Initially, the impact of A to I editing has been described for coding targets in the nervous system. Here, A to I editing leads to recoding and changes of single amino acids since inosine is
Tajaddod M, Jantsch MF, Licht K.
europepmc   +4 more sources

An orthology-based methodology as a complementary approach to retrieve evolutionarily conserved A-to-I RNA editing sites

RNA Biology
Adar-mediated adenosine-to-inosine (A-to-I) mRNA editing is a conserved mechanism that exerts diverse regulatory functions during the development, evolution, and adaptation of metazoans.
Jiyao Liu, Tianyou Zhao, Caiqing Zheng, Ling Ma, Fan Song, Li Tian, Wanzhi Cai, Hu Li, Yuange Duan   +8 more
doaj   +1 more source

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

Cell Reports, 2021
Summary: Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS). ADAR1 converts adenosines into inosines within dsRNA. This process called A-to-I
Richard de Reuver, Evelien Dierick, Bartosz Wiernicki, Katrien Staes, Leen Seys, Ellen De Meester, Tuur Muyldermans, Alexander Botzki, Bart N. Lambrecht, Filip Van Nieuwerburgh, Peter Vandenabeele, Jonathan Maelfait   +11 more
doaj   +1 more source

Genetic variation and microRNA targeting of A-to-I RNA editing fine tune human tissue transcriptomes

Genome Biology, 2021
Background A-to-I RNA editing diversifies the transcriptome and has multiple downstream functional effects. Genetic variation contributes to RNA editing variability between individuals and has the potential to impact phenotypic variability.
Eddie Park, Yan Jiang, Lili Hao, Jingyi Hui, Yi Xing   +4 more
doaj   +1 more source

Emerging roles of the RNA modifications N6-methyladenosine and adenosine-to-inosine in cardiovascular diseases

Molecular Therapy: Nucleic Acids, 2022
Cardiovascular diseases lead the mortality and morbidity disease metrics worldwide. A multitude of chemical base modifications in ribonucleic acids (RNAs) have been linked with key events of cardiovascular diseases and metabolic disorders.
Vilbert Sikorski, Antti Vento, Esko Kankuri   +2 more
doaj   +1 more source

ADAR3 expression is an independent prognostic factor in lower-grade diffuse gliomas and positively correlated with the editing level of GRIA2Q607R

Cancer Cell International, 2018
Background RNA editing by adenosine deaminases acting on RNA (ADARs) converts adenosines to inosines (A-to-I) in RNA, that alters gene expression and generates protein diversity.
Ying Zhang, Kuanyu Wang, Zheng Zhao, Si Sun, Kenan Zhang, Ruoyu Huang, Fan Zeng, Huimin Hu   +7 more
doaj   +1 more source

The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers

Genomics, Proteomics & Bioinformatics, 2023
Adenosine-to-inosine (A-to-I) RNA editing, constituting nearly 90% of all RNA editing events in humans, has been reported to contribute to the tumorigenesis in diverse cancers.
Sijia Wu, Zhiwei Fan, Pora Kim, Liyu Huang, Xiaobo Zhou   +4 more
doaj   +1 more source