Results 51 to 60 of about 135,681,880 (302)

Genomic Positional Dissection of RNA Editomes in Tumor and Normal Samples

Frontiers in Genetics, 2019
RNA editing is phenomenon that occurs in both protein coding and non-coding RNAs. Increasing evidence have shown that adenosine-to-inosine RNA editing can potentially rendering substantial functional effects throughout the genome.
Michael Chigaev, Hui Yu, David C. Samuels, Quanhu Sheng, Olufunmilola Oyebamiji, Scott Ness, Wei Yue, Ying-yong Zhao, Yan Guo   +8 more
doaj   +1 more source

Genetic variation and microRNA targeting of A-to-I RNA editing fine tune human tissue transcriptomes

Genome Biology, 2021
Background A-to-I RNA editing diversifies the transcriptome and has multiple downstream functional effects. Genetic variation contributes to RNA editing variability between individuals and has the potential to impact phenotypic variability.
Eddie Park, Yan Jiang, Lili Hao, Jingyi Hui, Yi Xing   +4 more
doaj   +1 more source

Emerging roles of the RNA modifications N6-methyladenosine and adenosine-to-inosine in cardiovascular diseases

Molecular Therapy: Nucleic Acids, 2022
Cardiovascular diseases lead the mortality and morbidity disease metrics worldwide. A multitude of chemical base modifications in ribonucleic acids (RNAs) have been linked with key events of cardiovascular diseases and metabolic disorders.
Vilbert Sikorski, Antti Vento, Esko Kankuri   +2 more
doaj   +1 more source

Language, Culture, and Cancer: Qualitative Insights Into Communication Disparities Among Spanish‐Speaking Caregivers of Children With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Latino children are projected to make up nearly one‐third of United States (US) children by 2060, and many of their caregivers speak Spanish. Prior survey research has documented communication difficulties for Spanish‐speaking caregivers of children with cancer, but contemporary qualitative data are limited.
Jenny Ruiz, Alejandra Curbelo‐Paz, Sonia Morales, Elizabeth Contreras, Amy Houtrow, Scott H. Maurer, Judy C. Chang   +6 more
wiley   +1 more source

The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers

Genomics, Proteomics & Bioinformatics, 2023
Adenosine-to-inosine (A-to-I) RNA editing, constituting nearly 90% of all RNA editing events in humans, has been reported to contribute to the tumorigenesis in diverse cancers.
Sijia Wu, Zhiwei Fan, Pora Kim, Liyu Huang, Xiaobo Zhou   +4 more
doaj   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Conserved A-to-I RNA editing with non-conserved recoding expands the candidates of functional editing sites

Fly
Adenosine-to-inosine (A-to-I) RNA editing recodes the genome and confers flexibility for the organisms to adapt to the environment. It is believed that RNA recoding sites are well suited for facilitating adaptive evolution by increasing the proteomic ...
Yuange Duan, Ling Ma, Tianyou Zhao, Jiyao Liu, Caiqing Zheng, Fan Song, Li Tian, Wanzhi Cai, Hu Li   +8 more
doaj   +1 more source

A nomogram based on A-to-I RNA editing predicting overall survival of patients with lung squamous carcinoma

BMC Cancer, 2022
Background Adenosine-to-inosine RNA editing (ATIRE) is characterized as non-mutational epigenetic reprogramming hallmark of cancer, while little is known about its predictive role in cancer survival.
Li Liu, Jun Liu, Xiaoliang Deng, Li Tu, Zhuxiang Zhao, Chenli Xie, Lei Yang   +6 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

A-to-I editing sites in female and male brains of D. melanogaster.

, 2017
A-to-I editing sites in female and male brains of D. melanogaster.
Shiqi Luo (3829597), Hong Zhang (25820), Shengqian Dou (3829591), Jian Lu (51707), Yuange Duan (3829594)   +4 more
core   +1 more source