Results 11 to 20 of about 8,093,612 (203)
Substitutional A‐to‐I RNA editing [PDF]
WIREs RNA, 2010 AbstractAdenosine‐to‐inosine (A‐to‐I) editing catalyzed by adenosine deaminases acting on RNA (ADARs) entails the chemical conversion of adenosine residues to inosine residues within double‐stranded RNA (dsRNA) substrates. Inosine base pairs as guanosine and A‐to‐I editing can therefore alter the structure and base pairing properties of the RNA ...
Bjorn-Erik, Wulff, Kazuko, Nishikura
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The cell line A-to-I RNA editing catalogue [PDF]
Nucleic Acids Research, 2020 Abstract Adenosine-to-inosine (A-to-I) RNA editing is a common post transcriptional modification. It has a critical role in protecting against false activation of innate immunity by endogenous double stranded RNAs and has been associated with various regulatory processes and diseases such as autoimmune and cardiovascular diseases as well
Eli Eisenberg +5 more
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Detecting and Characterizing A-To-I microRNA Editing in Cancer [PDF]
Cancers, 2021 Adenosine to inosine (A-to-I) editing consists of an RNA modification where single adenosines along the RNA sequence are converted into inosines. Such a biochemical transformation is catalyzed by enzymes belonging to the family of adenosine deaminases acting on RNA (ADARs) and occurs either co- or post-transcriptionally.
Gioacchino P. Marceca +5 more
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Widespread cleavage of A-to-I hyperediting substrates [PDF]
RNA, 2009 A-to-I RNA editing is the conversion of adenosine to inosine in double-stranded cellular and viral RNAs. Recently, abundant hyperediting of human transcripts, affecting thousands of genes, has been reported. Most of these editing sites are confined to intramolecular hairpin double-stranded RNA (dsRNA) structures formed by pairing of neighboring ...
Sivan, Osenberg +3 more
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N6-Methyladenosines Modulate A-to-I RNA Editing [PDF]
Molecular Cell, 2018 N6-methyladenosine (m6A) and adenosine-to-inosine (A-to-I) editing are two of the most abundant RNA modifications, both at adenosines. Yet, the interaction of these two types of adenosine modifications is largely unknown. Here we show a global A-to-I difference between m6A-positive and m6A-negative RNA populations.
Jian-Feng, Xiang +5 more
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A-to-I RNA Editing and Human Disease [PDF]
RNA Biology, 2006 The post-transcriptional modification of mammalian transcripts by A-to-I RNA editing has been recognized as an important mechanism for the generation of molecular diversity and also regulates protein function through recoding of genomic information.
Stefan, Maas +3 more
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De Novo A-to-I RNA Editing Discovery in lncRNA [PDF]
Cancers, 2020 Background: Adenosine to inosine (A-to-I) RNA editing is the most frequent editing event in humans. It converts adenosine to inosine in double-stranded RNA regions (in coding and non-coding RNAs) through the action of the adenosine deaminase acting on RNA (ADAR) enzymes.
Silvestris D. A. +4 more
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Nuclear Physics B, 2022 We study the Peccei-Quinn (PQ) symmetry of the sterile right-handed neutrino sector and the gauge symmetries of the Standard Model. Due to four-fermion interactions, spontaneous breaking of these symmetries at the electroweak scale generates top-quark ...
She-Sheng Xue
doaj +1 more source
Including state-of-the-art physical understanding of thermal vacancies in Calphad models
Scientific Reports, 2022 A physically sound thermochemical model accounting for explicit thermal vacancies in elements and alloys is presented. The model transfers the latest theoretical understanding of vacancy formation into the Calphad formalism where it can extend currently ...
A. Obaied, I. Roslyakova, M. To Baben
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BJGP Open, 2022 Background: Among the manifestations of COVID-19 are taste and smell disorders (TSDs). Aim: To evaluate the sensitivity and specificity of TSDs and other associated symptoms to estimate predictive values for determining SARS-CoV-2 infection.
Anna Ruiz-Comellas +7 more
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