Results 41 to 50 of about 8,093,612 (203)
A-to-I editing of the 5HT2C receptor and behaviour [PDF]
Briefings in Functional Genomics and Proteomics, 2006 Site-specific deamination of five adenosine residues in the pre-mRNA of the serotonin 2C receptor, 5HT2CR, alters the amino acid sequence of the encoded protein. Such RNA editing can produce 32 mRNA variants, encoding 24 protein isoforms that vary in biochemical and pharmacological properties.
Katheleen, Gardiner, Yunzhi, Du
openaire +2 more sources
Molecular Cancer, 2021 Background Adenosine deaminases acting on RNA (ADARs) modify many cellular RNAs by catalyzing the conversion of adenosine to inosine (A-to-I), and their deregulation is associated with several cancers.
Julia Ramírez-Moya +5 more
doaj +1 more source
Detection of A-to-I RNA Editing in SARS-COV-2 [PDF]
Genes, 2021 ADAR1-mediated deamination of adenosines in long double-stranded RNAs plays an important role in modulating the innate immune response. However, recent investigations based on metatranscriptomic samples of COVID-19 patients and SARS-COV-2-infected Vero cells have recovered contrasting findings. Using RNAseq data from time course experiments of infected
Ernesto Picardi +2 more
openaire +3 more sources
Adenosine to inosine editing by ADAR2 requires formation of a ternary complex on the GluR-B R/G site [PDF]
, 2002 RNA editing by members of the ADAR (adenosine deaminase that acts on RNA) enzyme family involves hydrolytic deamination of adenosine to inosine within the context of a double-stranded pre-mRNA substrate.
Collins, Cynthia H. +2 more
core +1 more source
Molecules, 2021 The consequences of manipulations in structure and amino acid composition of native cyclolinopeptide A (CLA) from linen seeds, and its linear precursor on their biological activities and mechanisms of action, are reviewed.
Michał Zimecki, Krzysztof Kaczmarek
doaj +1 more source
A-to-I RNA editing – thinking beyond the single nucleotide [PDF]
RNA Biology, 2017 Adenosine-to-inosine RNA editing is a conserved process, which is performed by ADAR enzymes. By changing nucleotides in coding regions of genes and altering codons, ADARs expand the cell's protein repertoire. This function of the ADAR enzymes is essential for human brain development. However, most of the known editing sites are in non-coding repetitive
Nabeel S. Ganem, Ayelet T. Lamm
openaire +2 more sources
Increased A-to-I RNA editing in atherosclerosis and cardiomyopathies
PLOS Computational Biology, 2023 Adenosine-to-inosine RNA editing is essential to prevent undesired immune activation. This diverse process alters the genetic content of the RNA and may recode proteins, change splice sites and miRNA targets, and mimic genomic mutations. Recent studies have associated or implicated aberrant editing with pathological conditions, including cancer ...
Tomer D. Mann +3 more
openaire +4 more sources
Querying the Guarded Fragment [PDF]
, 2014 Evaluating a Boolean conjunctive query Q against a guarded first-order theory F is equivalent to checking whether "F and not Q" is unsatisfiable. This problem is relevant to the areas of database theory and description logic.
Bárány, Vince +2 more
core +2 more sources
A-to-I RNA editing and hematopoiesis
Experimental HematologyAdenosine-to-inosine (A-to-I) RNA editing plays essential roles in modulating normal development and homeostasis. This process is catalyzed by adenosine deaminase acting on RNA (ADAR) family proteins. The most well-understood biological processes modulated by A-to-I editing are innate immunity and neurological development, attributed to ADAR1 and ADAR2,
Zhen, Liang +2 more
openaire +2 more sources
The dynamic epitranscriptome: A to I editing modulates genetic information [PDF]
Chromosoma, 2015 Adenosine to inosine editing (A to I editing) is a cotranscriptional process that contributes to transcriptome complexity by deamination of adenosines to inosines. Initially, the impact of A to I editing has been described for coding targets in the nervous system. Here, A to I editing leads to recoding and changes of single amino acids since inosine is
Tajaddod, Mansoureh +2 more
openaire +2 more sources