Results 151 to 160 of about 2,894 (182)

Pulmonary Endothelial Cells Recycle And Reuse Exogenous Alpha 1 Antitrypsin (A1AT)

A107. NEW CONCEPTS IN PROTEASES AND ANTIPROTEASES, 2011
Angelia D. Lockett, Daniela N. Petrusca, Mary Beth Brown, Philip A. Gurnev, Pat DeMoss, Andrew K. Fraser, Horia I. Petrache, Irina Petrache   +7 more
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A1AT In Human Neutrophil Granulocytes.

Blood, 2010
Abstract Abstract 3784 Alpha-1-antitrypsin (A1AT) is an important inhibitor of the neutrophil serine proteases elastase, cathepsin G, and proteinase 3. A1AT is produced mainly by the liver and secreted to plasma. A1AT deficiency caused by the PiZZ mutation in the A1AT gene leads to accumulation of mutated A1AT in the liver
Stine Novrup Clemmensen, Lars C. Jacobsen, Sara Roervig, Bent Adel Hansen, Martin Iversen, Jack B Cowland, Bo van Deurs, Bjarke Askaa, Niels Borregaard   +8 more
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EFFECT OF INHALED CHROMIUM ON PULMONARY A1AT

Inhalation Toxicology, 2002
A major health hazard to coal miners is development of emphysema following long-term exposure to coal dust. One mechanism underlying development of emphysema is the oxidation of critical methionine (Met) residues in antiproteolytic factor, alpha1-antitrypsin (A1AT) resulting in a protease-antiprotease imbalance in the lung.
Mitchell D. Cohen, Maureen Sisco, Kathy Baker, Lung-Chi Chen, Richard B. Schlesinger   +4 more
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a1-antitrypsin (A1AT) deficiency presenting with IgA nephropathy and nephrotic syndrome: is renal involvement caused by A1AT deposition?

Clinical Nephrology, 2008
The role of severe a1-antitrypsin (A1AT) deficiency in the predisposition of early-onset pulmonary emphysema and juvenile hepatic cirrhosis is well-established. Associated glomerulonephritis is unusual although it is well-recognized in children and young adults with the severe phenotype. We report the first adult case of A1AT deficiency presenting with
S M S, Ting, T, Toth, F, Caskey
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Fibromyalgia, mood disorders, and intense creative energy: A1AT polymorphisms are not always silent

NeuroToxicology, 2012
Persons with single copies of common alpha-1-antitrypsin polymorphisms such as S and Z are often considered "silent carriers". Published evidence however supports a complex behavioral phenotype or trait - intense creative energy ("ICE")-associated with A1AT polymorphisms. We now confirm that phenotype and present an association of fibromyalgia syndrome
Donald E, Schmechel, Christopher L, Edwards   +1 more
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A Study of DCR-A1AT in Healthy Adult Volunteers and Patients With A1ATD-Associated Liver Disease

Case Medical Research, 2019
Case Medical Research
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Rare A1AT variants in Polish patients with chronic respiratory disorders – Data from 2013 to 2016

3.1 Molecular Pathology and Functional Genomics, 2016
SERPINA1 gene encoding the alpha-1 antitrypsin (A1AT) protein is highly polymorphic. Apart from the most prevalent PI*S and PI*Z deficiency alleles, other so-called rare variants also predispose individuals to severe chronic respiratory disorders (CRDs).
Katarzyna Duk, Aneta Zdral, Radoslaw Struniawski, Beata Szumna, Adriana Rozy, Joanna Chorostowska-Wynimko   +5 more
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Evidence for alpha-1-antitrypsin (A1AT) polymerization in preeclampsia: A novel mechanism for endothelial cell injury

American Journal of Obstetrics and Gynecology, 2006
PREECLAMPSIA: A NOVEL MECHANISM FOR ENDOTHELIAL CELL INJURY IRINA BUHIMSCHI, GUOMAO ZHAO, GEORGE SAADE, CATALIN S. BUHIMSCHI, Yale University, Obstetrics/Gynecology, New Haven, Connecticut, Yale University, Ob./Gyn.R p=0.009], despite a significant increase its urinary excretion (O500 fold in sPE, p!0.001).
Irina Buhimschi, Guomao Zhao, George Saade, Catalin S. Buhimschi   +3 more
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Identification of citrullinated α1-antitrypsin (A1AT) in saliva in a mouse model of rheumatoid arthritis

Journal of Oral Biosciences
Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive joint destruction. Early diagnosis and treatment, before joint deformation or destruction occurs, are crucial. Identifying novel biomarkers for RA in saliva could potentially enable early detection of the disease, prior to its onset.We conducted a comprehensive proteomic ...
Wakako Sakaguchi, Juri Saruta, Yuko Yamamoto, Tomoko Shimizu, Shinya Fuchida, Keiichi Tsukinoki   +5 more
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Does hypersialylation compensate the functional Alpha1-AntiTrypsin (A1AT) deficiency in all critically ill patients?

Biochimie
Alpha-1 antitrypsin (A1AT) is the major circulating serine protease inhibitor. Hypersialylated glycoforms (HSG) are produced to boost A1AT anti-inflammatory and anti-protease properties. Their occurrence and prognostic impact outside severe COVID-19 or community-acquired pneumonia are unknown.
Malika Balduyck, Sarah Afif, Brigitte Onraed, Mercédes Jourdain, Saad Nseir, Pascal Pigny, Farid Zerimech, Dominique Deplanque, Karine Faure, Guillaume Lefevre, Kazali Alidjinou, Régis Bordet, Ilka Engelmann, Delphine Garrigue, Anne Goffard, Eric Kipnis, Myriam Labalette, Marc Lambert, David Launay, Daniel Mathieu, Claude Alain Maurage, Julien Poissy, Martine Remy, Boualem Sendid, Sophie Susen, Maxime Caillier, Laurent Schwarb Laurent, Michael Hisbergues   +27 more
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