Results 21 to 30 of about 308,524 (151)

Differential sensitivity of brainstem vs cortical astrocytes to changes in pH reveals functional regional specialization of astroglia [PDF]

, 2013
Astrocytes might function as brain interoceptors capable of detecting different (chemo)sensory modalities and transmitting sensory information to the relevant neural networks controlling vital functions.
Kasimov, V, Gourine, A, Patrushev, M, Marina, N, Castaldo, C, Kasparov, Sergey, Larina, O   +6 more
core   +1 more source

Astrocytes Stimulate Microglial Proliferation and M2 Polarization In Vitro through Crosstalk between Astrocytes and Microglia

, 2021
Microglia are resident immune cells of the central nervous system that act as brain-specific macrophages and are also known to regulate the innate immune functions of astrocytes through secretory molecules.
Sumin Kim, Youngsook Son
core   +1 more source

Placental Mesenchymal Stem Cells Promote the Polarization of Astrocytes Towards the A2 Phenotype by Modulating the TGF-β1 Signaling Pathway in Cerebral Ischemia-Reperfusion Rats. [PDF]

Biomolecules
Astrocytic function imbalance is a key factor affecting cerebral ischemia rehabilitation. Mesenchymal stem cells have therapeutic potential for cerebral ischemia, but their mechanisms remain unclear.
Liu N, Fu Y, Wu T, Chen D, Liu T, Ma H, Cao C, Ma B, Niu J, Liang X.   +9 more
europepmc   +2 more sources

Additional file 9 of Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury

, 2023
Additional file 8: Fig. S8. Morphological analysis of spinal cord on day 28 after SCI in different groups. A Representative images of spinal cord on day 28 post SCI with A1 or A2 astrocytes transplantation.
Jie Chang (378968), Lei Yang (102719), Fan Jiang (144211), Binyu Wang (7375019), Sheng Zhang (111330), Xiao Yu (139738), Zhanyang Qian (9467909), Jiang Cao (530256), Hongtao Chen (603492), Renyi Kong (9467912), Xiaojian Cao (272504)   +10 more
core   +1 more source

Morphological and physiological interactions of NG2-glia with astrocytes and neurons [PDF]

, 2007
Models of central nervous system (CNS) function have historically been based on neurons and their synaptic contacts - the neuronal doctrine. This doctrine envisages glia as passive supportive cells.
Hamilton, N., Wigley, R., Nishiyama, Akiko, Kirchhoff, F., Wigley, Rebekah, Butt, Arthur M., Hamilton, Niki, Kirchhoff, Frank, Nishiyama, A., Butt, Arthur, Hamilton, Niki; id_orcid, Butt, A., Wigley, Becky   +12 more
core   +1 more source

Astragaloside IV inhibits experimental autoimmune encephalomyelitis by modulating the polarization of both microglia/macrophages and astrocytes

, 2023
Astragaloside IV (AST IV), a major saponin component and active ingredient isolated from Astragalus membranaceus, has been well known to exhibit neuroprotective effects on diverse models of neurological diseases.
Yuqing Yan, Jiezhong Yu, Minfang Guo, Chunyun Liu, Cungen Ma, Jingwen Yu, Bingtao Mu, Gajendra Kumar, Tao Meng, Lijuan Song   +9 more
core   +1 more source

Tetramethylpyrazine promotes stroke recovery by inducing the restoration of neurovascular unit and transformation of A1/A2 reactive astrocytes [PDF]

, 2023
2,3,5,6-Tetramethylpyrazine (TMP) as an active ingredient extracted from a traditional Chinese herbal medicine Ligusticum chuanxiong Hort. has been proved to penetrate blood-brain barrier (BBB) and show neuroprotective effects on cerebral ischemia ...
Jian-feng Lei, Lei Wang, Xue-feng Feng, Yun Lu, Hui Zhao, Ming-cong Li, Zi-yue Lin, Man-zhong Li, Yu-ming Zhuang, Li, Ming-cong, Zhao, Hui, Feng, Xue-feng, Lin, Zi-yue, Lu, Yun, Li, Man-zhong, Lei, Jian-feng, Zhuang, Yu-ming, Wang, Lei   +17 more
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes

, 2018
Astrocyte reactivity is disease- and stimulus-dependent, adopting either a proinflammatory A1 phenotype or a protective, anti-inflammatory A2 phenotype.
Dilshan S. Harischandra, Désaubry, Laurent, Richard Gordon, Harischandra, Dilshan, Huajun Jin, Vellareddy Anantharam, Jin, Huajun, Harischandra, Dilshan S., Souvarish Sarkar, Kanthasamy, Anumantha, Laurent Désaubry, Anumantha Kanthasamy, Kanthasamy, Arthi, Luo, Jie, Matthew Neal, Jie Luo, Anantharam, Vellareddy, Sarkar, Souvarish, Gordon, Richard, Neal, Matthew, Arthi Kanthasamy   +20 more
core   +1 more source