Results 21 to 30 of about 113,957,618 (180)

An epitope-optimized human H3N2 influenza vaccine induces broadly protective immunity in mice and ferrets

npj Vaccines, 2022
There is a crucial need for an improved H3N2 influenza virus vaccine due to low vaccine efficacy rates and increased morbidity and mortality associated with H3N2-dominated influenza seasons.
Brianna L. Bullard, Jennifer DeBeauchamp, Matthew J. Pekarek, Erika Petro-Turnquist, Peter Vogel, Richard J. Webby, Eric A. Weaver   +6 more
doaj   +1 more source

Highly Cross-Reactive and Protective Influenza A Virus H3N2 Hemagglutinin- and Neuraminidase-Specific Human Monoclonal Antibodies

Microbiology Spectrum, 2023
Due to antigenic drift and shift of influenza A viruses (IAV) and the tendency to elicit predominantly strain-specific antibodies, humanity remains susceptible to new strains of seasonal IAV and is at risk from viruses with pandemic potential for which ...
Michael Piepenbrink, Fatai Oladunni, Aitor Nogales, Ahmed M. Khalil, Theresa Fitzgerald, Madhubanti Basu, Christopher Fucile, David J. Topham, Alexander F. Rosenberg, Luis Martinez-Sobrido, James J. Kobie   +10 more
doaj   +1 more source

H3N2 avian influenza viruses detected in live poultry markets in China bind to human-type receptors and transmit in guinea pigs and ferrets

Emerging Microbes and Infections, 2019
The H3N2 influenza viruses became widespread in humans during the 1968 H3N2 pandemic and have been a major cause of influenza epidemics ever since. Different lineages of H3N2 influenza viruses are also commonly found in animals. If a different lineage of
Lizheng Guan, Jianzhong Shi, Xingtian Kong, Shujie Ma, Yaping Zhang, Xin Yin, Xijun He, Liling Liu, Yasuo Suzuki, Chengjun Li, Guohua Deng, Hualan Chen   +11 more
doaj   +1 more source

Seasonal influenza vaccination expands hemagglutinin-specific antibody breadth to older and future A/H3N2 viruses

npj Vaccines, 2022
History of influenza A/H3N2 exposure, especially childhood infection, shape antibody responses after influenza vaccination and infection, but have not been extensively studied.
Nina Urke Ertesvåg, Rebecca Jane Cox, Sarah Larteley Lartey, Kristin G-I Mohn, Karl Albert Brokstad, Mai-Chi Trieu   +5 more
doaj   +1 more source

A Characterization and an Evolutionary and a Pathogenicity Analysis of Reassortment H3N2 Avian Influenza Virus in South China in 2019–2020

Viruses, 2022
Seasonal H3N2 influenza virus has always been a potential threat to public health. The reassortment of the human and avian H3N2 influenza viruses has resulted in major influenza outbreaks, which have seriously damaged human life and health. To assess the
Tengfei Liu, Yuhao Huang, Shumin Xie, Lingyu Xu, Junhong Chen, Wenbao Qi, Ming Liao, Weixin Jia   +7 more
doaj   +1 more source

Comparative analysis of Hemagglutinin of 2013 H3N2 Influenza A virus Indicates its Evolution from 1968 H3N2 Pandemic Influenza A virus

, 2020
Emergence of influenza A H3N2 is alarming. Strain 2013 H3N2 has H1 subtype Haemagglutinin (HA) gene segment replaced with a H3 HA gene segment. The vulnerability of the humans to H3 may be directly proportional to the HA alterations.
Sneham Tiwari, Amit K Banerjee, Debadatta Nayak, Neelima Arora, Shailendra K Saxena, Srinivasulu Gadugu, Swatantra Kumar, Sai V Chitti, Raj K Manchanda, Vimal K Maurya, Anil Khurana   +10 more
core   +1 more source

Molecular identification of neuraminidase gene mutations in influenza A/H1N1 and A/H3N2 isolates of Mazandaran province, north of Iran

Journal of Global Antimicrobial Resistance
Objectives: The neuraminidase (NA) mutations causing resistance to NA inhibitors (NAIs) mostly compromise the fitness of influenza viruses. Considering the importance of these mutations, constant monitoring of the effectiveness of available drugs is ...
Mehdi Rabie-Rudsari, Emad Behboudi, Ategheh Ranjkesh, Kimia Kaveh, Hadi Razavi-Nikoo, Mohammad Reza Haghshenas, Abdolvahab Moradi   +6 more
doaj   +1 more source

H3N2 canine influenza virus-like particle vaccine with great protection in beagle dogs

Microbiology Spectrum
In 2016, a distinct branch of H3N2 canine influenza virus (CIV) emerged, which has mutations related to mammalian adaptation and has replaced previously prevalent strains. This branch poses a risk of zoonotic infection.
Fei-fei Ge, Li-pin Shen, De-quan Yang, Xian-cao Yang, Xin Li, Hai-xiao Shen, Jian Wang, Shixin Huang   +7 more
doaj   +1 more source

H3N2 Virus Outbreak: A latest global threat

Journal of Zoonotic Diseases, 2023
The current H3N2 virus outbreak has sent shockwaves worldwide, with health officials rushing to stop its spread. This form of influenza has been wreaking havoc around the globe, culminating in an alarming number of hospitalizations and fatalities.
Manisha Vohra , Mohammad Amir , Amit Sharma , Ian Osoro   +3 more
doaj   +1 more source

Renal Clearable Luminogenic Reporter for Ultrasensitive Influenza Virus Imaging and Efficient Antiviral Therapies Monitoring in Living Mice

Advanced Science, EarlyView.
A viral luminogenic reporter with chemiluminescence/fluorescence dual‐response and efficient renal clearance was developed for non‐invasive imaging and urinalysis of H1N1 virus protease, allowing for remote detection of H1N1 virus infections and monitoring of antiviral therapeutic efficacy in living mice.
Bankang Ruan, Chudan Liang, Meilin Hu, Weiping Xu, Jingjing Che, Jun Qian, Bingcai Jiang, Linna Liu, Xiancai Ma, Jiaguo Huang   +9 more
wiley   +1 more source