Results 41 to 50 of about 28,370 (183)

1968 Hong Kong Gribi Pandemisinin Türkiye’deki Tarihsel Gelişimi ve Etkileri

Turcology Research
Salgın hastalıkların tarihi insanlık tarihi kadar eskidir. İnsan var olduğu günden beri hastalıklar da var olmuş, bunların bazıları salgın hâline gelip, kıtalara hatta tüm dünyaya yayılarak pandemiye dönüşmüş ve milyonlarca insanın ölümüne yol açmıştır ...
Birgül Küçük Turgut, Elif Aktaş
doaj   +1 more source

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, EarlyView.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

Toward Predicting Pandemic Potential: A Comparative Analysis of Virus‐Host Interactions Between Diverse Influenza A Viruses and the Human Innate Immune System

PROTEOMICS, EarlyView.
ABSTRACT Zoonotic infections caused by influenza A viruses (IAVs) of animal origin are a major public health concern, as they may represent the initial step toward the emergence of a pandemic strain. The host range of IAVs is shaped by species‐specific virus‐host interactions, and several host barriers have been identified that restrict the adaptation ...
Antoine Gerodez, Melanie Dos Santos, Mikaël Attia, Killian De Geest, Ibrahim Hamid, Rodrigue Tesse, Ilham Fdillate, Marc Boschmans, Steven Van Borm, Mieke Steensels, Benedicte Lambrecht, Lionel Tafforeau, Caroline Demeret, Cyril Barbezange   +13 more
wiley   +1 more source

Characterization and Evolutionary Analysis of a Novel H3N2 Influenza A Virus Glycosylation Motif in Southern China

Frontiers in Microbiology, 2020
An influenza A (H3N2) virus epidemic occurred in China in 2017 and the causative strain failed to bind red blood cells (RBCs), which may affect receptor binding and antibody recognition.
Zhiqi Zeng, Lee-Fong Yau, Zengxian Lin, Xuanzi Xia, Zifeng Yang, Zifeng Yang, Jing-Rong Wang, Wenjun Song, Wenjun Song, Xinhua Wang, Xinhua Wang   +10 more
doaj   +1 more source

Deep Mutational Scanning for the Study and Engineering of Protein Assemblies

Chemistry–Methods, Volume 6, Issue 8, August 2026.
This review explores how deep mutational scanning (DMS) can be used to improve understanding and accelerate engineering of protein assemblies, from natural fibers to engineered nanocages. We discuss various types of protein assemblies and their characterization, provide an introduction to the DMS technique, and then highlight examples in which DMS has ...
Jenna B. Wolfanger, Shoili Banerjee, Carolyn E. Mills   +2 more
wiley   +1 more source

The V223I substitution in hemagglutinin reduces the binding affinity to human-type receptors while enhancing the thermal stability of the H3N2 canine influenza virus

Frontiers in Microbiology
Given the intimate relationship between humans and dogs, the H3N2 canine influenza viruses (CIVs) pose a threat to public health. In our study, we isolated four H3N2 CIVs from 3,758 dog nasal swabs in China between 2018 and 2020, followed by genetic and ...
Liling Liu, Fujun Wang, Fujun Wang, Ying Wu, Weiyong Mi, Yaping Zhang, Lei Chen, Dongxue Wang, Guohua Deng, Jianzhong Shi, Hualan Chen, Huihui Kong   +11 more
doaj   +1 more source

Phosphoproteomics to Characterize Host Response During H3N2 Canine Influenza Virus Infection of Dog Lung

Frontiers in Veterinary Science, 2020
Avian-origin H3N2 canine influenza viruses (CIVs) cause severe contagious respiratory disease in dogs, and quickly adapt to new environments. To further understand the mechanism of virus infection and host-virus interactions, we characterized the ...
Yongbo Liu, Yongbo Liu, Yongbo Liu, Cheng Fu, Shaotang Ye, Shaotang Ye, Shaotang Ye, Yingxin Liang, Yingxin Liang, Yingxin Liang, Zhonghe Qi, Zhonghe Qi, Zhonghe Qi, Congwen Yao, Congwen Yao, Congwen Yao, Zhen Wang, Zhen Wang, Zhen Wang, Ji Wang, Ji Wang, Ji Wang, Siqi Cai, Siqi Cai, Siqi Cai, Shiyu Tang, Shiyu Tang, Shiyu Tang, Ying Chen, Ying Chen, Ying Chen, Shoujun Li, Shoujun Li, Shoujun Li   +33 more
doaj   +1 more source

Prognostic Value of Clinical and Laboratory Markers in Hospitalized Influenza‐Positive Patients: A Retrospective Cohort Study With ROC‐Based Risk Stratification

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Seasonal influenza continues to cause substantial morbidity and mortality worldwide. Identifying reliable clinical and paraclinical predictors of adverse outcomes may aid in early triage and management. This study aimed to evaluate clinical and paraclinical factors associated with prolonged hospitalization, ICU admission ...
Mohsen Daneshmand, Arefeh Ebrahimian Shiadeh, Farzane Sadeghi, Hemmat Gholinia, Farzin Sadeghi, Masomeh Bayani   +5 more
wiley   +1 more source

Ineffectiveness of the 2014-2015 H3N2 influenza vaccine

Oncotarget, 2015
The seasonal influenza vaccine is currently the most effective preventive modality against influenza infection. Nasopharyngeal samples of vaccinated and non-vaccinated patients presenting with Influenza-like-illness (ILI) were collected from over 20 outpatient clinics located in different geographic parts of Israel and were tested for the presence of ...
Michal, Mandelboim, Aharona, Glatman-Freedman, Yaron, Drori, Hilda, Sherbany, Rakefet, Pando, Hanna, Sefty, Hila, Zadka, Tamar, Shohat, Nathan, Keller, Ella, Mendelson   +9 more
openaire   +3 more sources

The order of infection shapes disease outcomes in influenza and herpes simplex virus coinfection by modulating immune responses

Virology Journal
Background Coinfections of influenza A virus (IAV) and herpes simplex virus type 1 (HSV-1) have been increasingly reported in patients with severe pneumonia, yet their pathogenesis remains poorly understood.
Yuanjun Lyu, Kailin Mai, Hongxuan Zhou, Chunguang Yang, Yunceng Weng, Zhenhui Zhang, Yang Wang, Zifeng Yang   +7 more
doaj   +1 more source