Results 71 to 80 of about 58,761 (268)

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu   +10 more
wiley   +1 more source

Fitted Operator Method for Singularly Perturbed Delay Parabolic Problems With Boundary Turning Points

open access: yesInternational Journal of Mathematics and Mathematical Sciences
In this paper, a numerical scheme for time-delay singularly perturbed parabolic convection-diffusion problems with boundary turning points is presented.
Yimesgen Mehari Kebede   +2 more
doaj   +1 more source

Second-Order Perturbative Solutions for 3-D Electromagnetic Radiation and Propagation in a Layered Structure With Multilayer Rough Interfaces

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2015
We present a fast method for deriving a general explicit closed-form expression of second-order perturbative solutions of the problem of radiation and propagation electromagnetic (EM) fields in a hybrid layered structure with an arbitrary number of rough interfaces and planar stratified medium based on the classical small perturbation method (SPM). The
Chao Wu, Xiaojuan Zhang
openaire   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito   +14 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina   +11 more
wiley   +1 more source

Drag flow analysis of Oldroyd eight constant fluid

open access: yesAlexandria Engineering Journal, 2016
This article presents the steady drag flow problems. The incompressible Oldroyd eight constant fluid flow is considered between two infinite parallel plates.
A.M. Siddiqui   +3 more
doaj   +1 more source

Asymptotic approximation to a solution of a singularly perturbed linear-quadratic optimal control problem with second-order linear ordinary differential equation of state variable

open access: yesNumerical Algebra, Control & Optimization, 2021
<p style='text-indent:20px;'>The direct scheme method is applied to construct an asymptotic approximation of any order to a solution of a singularly perturbed optimal problem with scalar state, controlled via a second-order linear ODE and two fixed end points. The error estimates for state and control variables and for the functional are obtained.
openaire   +2 more sources

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

open access: yesArthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo   +88 more
wiley   +1 more source

Numerical study of self-adjoint singularly perturbed two-point boundary value problems using collocation method with error estimation

open access: yesJournal of Ocean Engineering and Science, 2018
A numerical treatment for self-adjoint singularly perturbed second-order two-point boundary value problems using trigonometric quintic B-splines is presented, which depend on different engineering applications.
Khalid K. Ali   +2 more
doaj   +1 more source

Differential Item Functioning on the Patient Health Questionnaire 8 by Disease Subtype, Language, Sex, and Age Among People With Systemic Sclerosis: A Scleroderma Patient‐Centered Intervention Network Cohort Study

open access: yesArthritis Care &Research, EarlyView.
Objective Somatic items used in depression assessments can potentially overlap with symptoms related to physical illness, including systemic sclerosis (SSc). No studies have looked at whether somatic depression items may be influenced by diffuse versus limited SSc disease subtypes, which are associated with varying degrees of symptom presentation.
Sophie Hu   +110 more
wiley   +1 more source

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