Results 121 to 130 of about 131,610 (332)
812. Non-Human Primate Serotype rh.10 AAV Directed Therapeutic Serum Levels of α1-antitrypsin Following Intrapleural Administration in Mice with Pre-Existing Immunity to AAV [PDF]
, 2005 openalex +1 more source
Advanced Science, EarlyView.FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu +12 more
wiley +1 more source
Frontiers in Bioengineering and BiotechnologyCell and gene therapy (CGT) is a field of therapeutic medicine that aims to treat, prevent, and cure diseases using engineered cells (stem cells, immune cells, and differentiated adult or fetal cells), vectors [Adeno Associated Virus (AAV), Adeno Virus ...
Samantha Schrecke +7 more
doaj +1 more source
Advanced Science, EarlyView.Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu +14 more
wiley +1 more source
Advancing AAV vector manufacturing: challenges, innovations, and future directions for gene therapy
Frontiers in Molecular MedicineAdeno-Associated Virus (AAV) vectors are at the forefront of gene therapy, offering transformative therapeutic potential for many genetic disorders.
N. Charan S. S. Kowshik +1 more
doaj +1 more source
Qubit state tomography in superconducting circuit via weak measurements
, 2016 The standard method of "measuring" quantum wavefunction is the technique of {\it indirect} quantum state tomography. Owing to conceptual novelty and possible advantages, an alternative {\it direct} scheme was proposed and demonstrated recently in quantum
Feng, Wei +3 more
core +1 more source
Advanced Science, EarlyView.Wang et al reveal that in the olfactory system, the selective impairment of gamma‐driven Barcode features underlying early olfactory deficits, while the selective impairment of theta‐driven Barcode features underlying later cognitive deficits, further establishing cross‐network gamma oscillations in the early stage as a biomarker of later cognitive ...
Shuaishuai Wang +13 more
wiley +1 more source
Adeno-Associated Virus (AAV) Gene Therapy pada Hemofilia: A Systematic Review
Majalah Kedokteran AndalasHemofilia A (HA) dan Hemofilia B (HB) adalah kelainan perdarahan terkait kromosom X yang disebabkan oleh defisiensi faktor koagulasi Faktor VIII (FVIII) atau Faktor IX (FIX).
Winda Angriani, Fitrah Afdhal
doaj +1 more source
Advanced Science, EarlyView.A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li +8 more
wiley +1 more source