Results 141 to 150 of about 144,727 (384)

AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset

Nature Neuroscience, 2021
David Goertsen, Nicholas C. Flytzanis, N. Goeden, Miguel R. Chuapoco, A. Cummins, Yijing Chen, Yingying Fan, Qiangge Zhang, Jitendra Sharma, Yangyang Duan, Liping Wang, G. Feng, Yu Chen, N. Ip, J. Pickel, V. Gradinaru   +15 more
semanticscholar   +1 more source

Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice

Advanced Science, EarlyView.
PSTNVglut2 neurons function as a new central baroreflex hub via projections to the NTS, modulating parasympathetic cardiac output to maintain cardiovascular homeostasis while synchronously regulating locomotion. Blood pressure fluctuations negatively correlate with locomotor performance.
Ming‐Xuan Lu, Jin‐Yin Huang, Xing‐Zhe Xu, Ji‐Yu Sun, Dan‐Ni Zou, Jia‐Yao Zhang, Chen Chi, Qi Zhang, Wei‐Cai Liu   +8 more
wiley   +1 more source

Editorial: Gene therapy 2.0: Biotechnology for circuit engineering and complex therapeutic approaches

Frontiers in Bioengineering and Biotechnology, 2022
Luís Quintino, Luís Pereira de Almeida, Cecilia Lundberg   +2 more
doaj   +1 more source

Implementation of the quality-by-design concept for an adeno-associated viral vector-based gene therapy

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. Currently, manufacturers of adeno-associated virus (AAV)-based gene therapy products are facing a number of systemic problems stemming from the difficulties in assessing the quality of medicinal products due to insufficient scientific data,
D. S. Kopein, G. N. Poroshin, R. A. Khamitov   +2 more
doaj   +1 more source

A Phase I Study of AAV-CFTR Administration in Adult Cystic Fibrosis Patients 1794 [PDF]

, 1997
Terence R. Flotte, Pamela L. Zeitlin, Richard Daifuku, Sandra Afione, Erik M. Schwiebert, Sharon Allen, Suzanne E. Beck, Thomas Reynolds, Mary Wagner, Lois Brass‐Ernst, Greenberry Taylor, Randall C. Wetzel, Kevin Sullivan, Sandra Friborg, Margaret Humphries, Kye Chesnut, S. R. Goodwin, Beryl J. Rosenstein, B. J. Carter, William B. Guggino   +19 more
openalex   +1 more source

A dual‐AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock‐out mice

EMBO Molecular Medicine, 2018
Normal hearing and synaptic transmission at afferent auditory inner hair cell (IHC) synapses require otoferlin. Deafness DFNB9, caused by mutations in the OTOF gene encoding otoferlin, might be treated by transferring wild‐type otoferlin cDNA into IHCs ...
H. Al-Moyed, A. Cepeda, Sangyong Jung, T. Moser, S. Kügler, E. Reisinger   +5 more
semanticscholar   +1 more source

Tumor Extracellular Vesicles Aggravate Mitochondrial Damage in Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
This study reveals a novel mechanistic connection between cancer and ischemia/reperfusion (I/R)‐induced cardiac injury. The meta‐analysis demonstrates significantly higher incidence ratios of both all‐cause mortality and cardiovascular mortality in cancer patients undergoing percutaneous coronary intervention (PCI) compared to non‐cancer patients.
Zhongting Mei, Qian Liu, Guoxin Liu, Manjie Zhang, Jiaxin Fang, Xuting He, Xueqi He, Zhengwei Qin, Ronghua Liu, Chuang Liu, Hongyu Ji, Yuechao Dong, Ye Yuan, Baofeng Yang, Weijie Du   +14 more
wiley   +1 more source

Qubit state tomography in superconducting circuit via weak measurements

, 2016
The standard method of "measuring" quantum wavefunction is the technique of {\it indirect} quantum state tomography. Owing to conceptual novelty and possible advantages, an alternative {\it direct} scheme was proposed and demonstrated recently in quantum
Feng, Wei, Li, Xin-Qi, Qin, Lupei, Xu, Luting   +3 more
core   +1 more source

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
wiley   +1 more source

AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice

Nature, 2022
Jiaming Wang, Yue Zhang, Craig A Mendonca, O. Yukselen, Khaja Muneeruddin, Lingzhi Ren, Jialing Liang, Chendong Zhou, Jun Xie, Jia Li, Zhong Jiang, Alper Kucukural, Scott A Shaffer, Guangping Gao, Dan Wang   +14 more
semanticscholar   +1 more source