Results 151 to 160 of about 121,774 (253)

Long-term survival and mortality characteristics of patients with ANCA-associated vasculitis on maintenance hemodialysis: a propensity score-matched study from the Wuhan registry (2017-2025). [PDF]

BMC Nephrol
Hu Y, Wan S, Min Y, Song Y, Shao D, Shi M, Huang Q, Tu C, Xiong F.   +8 more
europepmc   +1 more source

Implications of the FDA's new plausible mechanism framework for the development of a personalized in vivo prime editing platform. [PDF]

Am J Hum Genet
Feierman ER, Whittaker MN, Quigley A, Brooks DL, McVeigh P, Nan AX, Hsu A, Said H, Soliman OY, Giovenco R, Davidson BL, Alameh MG, Liu DR, Wang X, Musunuru K, Ahrens-Nicklas RC.   +15 more
europepmc   +1 more source

Protocol for targeted peripheral adeno-associated viral vector transduction of the intradental neurons in mice. [PDF]

STAR Protoc
Liu LY, Chang A, Berthaume IT, Emrick JJ.   +3 more
europepmc   +1 more source

Therapeutic Dilemmas in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: Diffuse Alveolar Hemorrhage and Venous Thromboembolism. [PDF]

ACR Open Rheumatol
Ediboglu ED, Falde SD, Baqir M, Cartin-Ceba R, McBane R, Specks U.   +5 more
europepmc   +1 more source

Adeno-Associated Virus Toxicity in Duchenne Muscular Dystrophy: Mechanisms and Clinical Considerations. [PDF]

Genes (Basel)
Saylam E, D'ambrosio ES, Pesco MT, Gushchina LV.   +3 more
europepmc   +1 more source

Generation of Allogeneic CAR‐T Circumvents Functional Deficits in Patient‐Derived Autologous Product for Glioblastoma

International Journal of Cancer, EarlyView.
Clinical trials of chimeric antigen receptor T‐cell (CAR‐T) therapies in glioblastoma have shown limited clinical benefits. Whether this may be explained by the basal quality of CAR‐T products, which are currently generated using patient, autologous T‐cells, has been little explored.
Sabra K. Salim, Muhammad Vaseem Shaikh, Jeffrey Wei, William T. Maich, Alisha Anand, Oliver Y. Tang, Minomi K. Subapanditha, Zahra Alizada, Yujin Suk, Manoj Singh, Kui Zhai, Aapti Khanna, Benjamin Brakel, Vassil Dimitrov, Zoya Tabunshchyk, Katie Chan, Kevin R. Brown, Parvez Vora, Donald M. O'Rourke, Zev A. Binder, Chitra Venugopal, Jason Moffat, Sheila K. Singh   +22 more
wiley   +1 more source

Downregulation of Cathepsin B expression alleviates periodontitis by reducing mitochondrial reactive oxygen species production and NOD-, LRR-, and pyrin domain-containing 3 -mediated pyroptosis. [PDF]

Front Immunol
Wang T, Liu X, Li J, Ding Y, Yue Y, Li J, Wang M, Wei N, Hao L.   +8 more
europepmc   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Interleukin-27 remodels the bone marrow niche to suppress B-cell development and leukaemia progression in mouse models. [PDF]

EBioMedicine
Zhu JM, Xia J, Chen KM, Bai XF, Duan CW.
europepmc   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source