Results 171 to 180 of about 89,643 (298)

In-Depth Market Analysis of AAVE (AAVE-USD) for Investors

Abstract: AAVE (AAVE-USD) posted a strong 51.45% price gain over the past year, accompanied by a daily volatility of 5.56% and a Sharpe ratio of 0.91, indicating decent risk‑adjusted returns. The 14‑day RSI sits at 39.14, hinting at modest oversold pressure but still near the neutral zone.
openaire   +1 more source

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Exploration of the genetic architecture of ANCA-associated vasculitis. [PDF]

EBioMedicine
Byun J, Shaw VR, Zhu C, Han Y, Sun R, Zhang Z, Xiao X, Pinder BD, Zhang J, Tadesse Y, Riley TR, Chung S, Cuthbertson D, Dellaripa PF, Dua AB, Gewurz-Singer O, Forbess LJ, Langford CA, Khalidi N, Koening C, Mahr AD, McAlear C, Monach PA, Moreland L, Pagnoux C, Seo EP, Specks U, Spiera RF, Sreih A, Springer JM, St Clair EW, Warrington KJ, Ytterberg SR, Edberg JC, Grayson PC, Jayne D, Smith R, Walsh M, Merkel PA, Siminovitch KA, Amos CI, Vasculitis Clinical Research Consortium.   +41 more
europepmc   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

AAV vector-mediated <i>ALDH5A1</i> gene replacement improves survival and metabolic correction in a severe mouse model of SSADH deficiency. [PDF]

Mol Ther Adv
Koshu K, Horiguchi A, Mizuno T, Aoki S, Watanabe M, Takino N, Ito M, Jimbo EF, Muramatsu K, Muramatsu SI, Osaka H.   +10 more
europepmc   +1 more source

A Molecularly Defined Midbrain Circuit Mechanism for Sound‐Driven Defensive Behavior and Anxiety

Advanced Science, EarlyView.
Schematic diagram showing the Cbln2+ ICx–dPAG circuit for sound‐driven defensive and anxiety‐like behaviors. ABSTRACT The innate defense behaviors in response to threatening sounds play a fundamental role in survival. However, the neural circuits that detect threat‐relevant auditory cues and transform them into defensive behaviors remain poorly defined.
Jie Cao, Xingxing Lai, Lifang Huo, Zhouyuan Zheng, Qian Zhang, Zhimin Ye, Panpan Wan, Chao Ma, Congping Shang   +8 more
wiley   +1 more source

Exploratory Risk Assessment of Cardiovascular Diseases Using Antiphospholipid Antibody-Related Scores in Patients with ANCA-Associated Vasculitis. [PDF]

J Clin Med
Kwon OC, Park YB, Lee SW.
europepmc   +1 more source

AAV-mediated transduction of songbird retina

Introduction: Genetic manipulation of murine retinal tissue through ocular administration of adeno-associated viruses (AAVs) has become a standard technique to investigate a multitude of mechanisms underlying retinal physiology. Resultantly, developments
B Satish (21607490), E Mendoza (17752173), KW Koch (21607499), R Feederle (21035201), H Mouritsen (21035186), I Musielak (21607496), K Dedek (21035189), K Haase (17664948), L Borowsky (21607493), C Scharff (21035183), Pranav Seth (17814005), D Heyers (21607487)   +11 more
core  

Clinical and Immunological Factors Associated with Disease Activity in MPO-ANCA-Associated Vasculitis. [PDF]

Open Access Rheumatol
Chen Y, Shuai Z.
europepmc   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source