Antiviral efficacy of LNP-delivered IFN-α14-ApoAI mRNA for chronic hepatitis B. [PDF]
Yang Q +10 more
europepmc +1 more source
Abstract Objective Surgical decision‐making in temporal lobe epilepsy (TLE) faces a critical challenge in determining whether the hippocampus can be safely spared during anterior temporal resection, particularly when surgery involves the language‐dominant hemisphere.
Guhan Seshadri NP +6 more
wiley +1 more source
Synergistic antioxidant and gene supplementation for high-efficacy retinitis pigmentosa therapy. [PDF]
Wu F +9 more
europepmc +1 more source
Pediatric epilepsy surgery: Global survey of invasive explorations
Abstract Objective Invasive presurgical evaluation plays a key role in pediatric epilepsy surgery, particularly in magnetic resonance imaging (MRI)‐negative cases, by guiding resective, disconnective, or ablative procedures. This International League Against Epilepsy (ILAE) Pediatric Epilepsy Surgery Taskforce study provides an updated global overview ...
Georgia Ramantani +96 more
wiley +1 more source
Safety of Adeno-Associated Viral Vectors in Gene Therapy: Mechanisms of Toxicity, Clinical Risks, and Strategies for Their Minimization. [PDF]
Tsaregorodtseva TS +6 more
europepmc +1 more source
Abstract Objective Detection of focal cortical dysplasia (FCD) remains a major challenge in presurgical epilepsy diagnostics. Magnetic resonance imaging (MRI) morphometry increasingly improves lesion detection and postsurgical outcomes. The volume‐based Morphometric Analysis Program, version 2018 (MAP18) with integrated artificial neural network and ...
Lara Bücheler +17 more
wiley +1 more source
Overlap of PR3-Positive ANCA-Associated Vasculitis and Primary Focal Segmental Glomerulosclerosis: A Case Report, Patient Perspective, and Review of the Literature. [PDF]
Landsberg A +4 more
europepmc +1 more source
Inherited metabolic epilepsies–established diseases, new approaches
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
PACS2 Alleviates Sepsis-Induced Myopathy by Activating ERK-MAPK Signalling Pathway to Suppress ER-Phagy. [PDF]
Li X +7 more
europepmc +1 more source
New insights into epileptic spasm generation and treatment from the TTX animal model
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann +2 more
wiley +1 more source

