Results 181 to 190 of about 121,774 (253)

The secretory protein, CLCF1, improves cholestatic liver disease by inhibiting hepatic bile acid synthesis and promoting bile acid excretion. [PDF]

Commun Biol
Liu M, Su Y, Hu Y, Shen M, Bao S, Gong Y, Ji Y, Wang L, Zhang Y, Wang X, Yang H, Chang Y, Zhou L.   +12 more
europepmc   +1 more source

Modulation of the Stress Granule Component Carhsp1 Mitigates Disease‐Associated Deficits in Spinocerebellar Ataxia Type 3 Mouse Models

Movement Disorders, EarlyView.
Abstract Background Spinocerebellar ataxia type 3 (SCA3) is a polyglutamine (polyQ) neurogenerative disorder that results from CAG trinucleotide repeat expansions in the ATXN3 gene, leading to toxic protein aggregate formation and cellular pathway dysfunction.
Tiago Moreira‐Gomes, Adriana Marcelo, Ana Teresa Rajado, Rafael G. Costa, Ricardo Afonso‐Reis, Cristiana R. Madeira, Inês T. Afonso, David V.C. Brito, Adriana A. Vaz, Clévio Nóbrega   +9 more
wiley   +1 more source

Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer's disease. [PDF]

Signal Transduct Target Ther
Baek S, Jang J, Yeo S, Jung HJ, Choe Y.
europepmc   +1 more source

Indirect Striatal Projection Neurons Drive a D2 Receptor‐Dependent Pathway to Dyskinesia and Dystonia

Movement Disorders, EarlyView.
D2 receptor ablation in indirect‐pathway striatal neurons reduces or abolishes dyskinetic and dystonic behaviors induced by L‐DOPA or D2 receptor agonists, respectively. Contralateral turning is reduced, while forward locomotion is increased. These effects are associated with modulation of neuronal activity in dorsal striatum and external globus ...
Laura Andreoli, Teodor Nyman, Elena Espa, Johan Jakobsson, Osama F. Elabi, Maria Angela Cenci   +5 more
wiley   +1 more source

Mitochondrial DNA Damage in Substantia Nigra Pars Compacta Astrocytes Exacerbates Dopaminergic Neuron Loss in a 6-Hydroxydopamine Mouse Model of Parkinsonism. [PDF]

Cell Mol Neurobiol
Ayala DA, Hall GM, Das D, Tijerina E, Villagran LL, Khan Z, Paliwal D, Anand A, Rimer M, Srinivasan R.   +9 more
europepmc   +1 more source

Mesh design for electrical resistivity imaging of agricultural dikes

Near Surface Geophysics, EarlyView.
Abstract Electrical resistivity imaging (ERI) shows promise for investigating earthen flood barriers. We are interested in the applicability of ERI for aiding maintenance and construction efforts on agricultural dikes in the upper Bay of Fundy, Canada.
Peter G. Lelievre, Elias Vandenberg, Heidi Hebb, Karl Butler   +3 more
wiley   +1 more source

Local delivery of OSK factors enables partial cellular reprogramming to mitigate osteoarthritis and cartilage fibrosis. [PDF]

Exp Mol Med
Liu YW, Zou JT, Gong JS, Jin L, Cao J, He ZH, Qian YX, Wang X, Wan MD, Hu XY, Hong CG, Du W, Chen CY, Liu HJ, Xie H, Wang ZX.   +15 more
europepmc   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source