Results 161 to 170 of about 89,643 (298)

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Mapping of Pre-Existing Humoral Immunity to AAV and Natural AAV Capsid Presence in Human Tissues: Observations from a Polish Surgical Cohort. [PDF]

Viruses
Majewska A, Siejda KW, Kowalec M, Aleksandrowicz K, Panchuk Y, Rogala MM, Pianka K, Minich A, Jarocka W, Walędziak M, Komorowska K, Kwiatkowski A, Rydzik S, Syryło T, Bajek A, Wiłkojć M, Gryszko L, Suwalski G, Mróz J, Zembala M, Doniec J, Brodaczewska KK, Lisowski L.   +22 more
europepmc   +1 more source

AAV-IKV mediated expression of decorin inhibits EMT and fibrosis in a murine model of Glaucoma and AAV-IKV transduction in Non-Human Primates

Primary open angle glaucoma (POAG) and infantile aphakic glaucoma (IAG) are significant contributors of vision loss in adults and infants respectively. Both indications are associated with fibrosis of the trabecular meshwork (TM) that attenuates aqueous ...
Manish Mishra, Rajendra Kumar-Singh, Pushpa Rao, Siobhan M. Cashman, David S. Walton   +4 more
core   +1 more source

FBP1‐Mediated Compartmentalization of Glycolytic Enzyme Complexes Suppresses PKM2 Function to Ameliorate MASLD Progression

Advanced Science, EarlyView.
In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang, Yiping Tang, Na Li, Xuening Dai, Jing Wu, Bin Xue, Yuxin Chen, Jingzi Zhang, Lingdong Kong, Chaojun Li, Lei Fang   +10 more
wiley   +1 more source

Challenges and innovations in cardiac AAV gene delivery as a platform for cardiac regeneration. [PDF]

NPJ Biomed Innov
Kabboul G, Izurieta Muñoz A, Bishawi M, Doering CB, Levit RD.   +4 more
europepmc   +1 more source

14-day long-term determination of GFP-positive hRPE cells transduced with AAV-2-CMV-GFP, AAV-6-CMV-GFP, or AAV-DJ-CMV-GFP.

The transduction was performed using 1 x 104 hRPE cells with AAV-2, AAV-6, or AAV-DJ at an MOI of 5 x 104, and the cells were stained with 4 ng/104 cells of Hoechst.
Jan Tode (14185648), Roland Meister (18086540), Xiaonan Hu (1235328), Heiko Fuchs (698121), Carsten Framme (9462824)   +4 more
core   +1 more source

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

Advanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han, Minwoo Wendy Jang, Taeyoung Park, Ki Jung Kim, Victor James Drew, Sunpil Kim, Tai Young Kim, Mingu Gordon Park, Myeongju Kim, Seung Won Chung, Minah Suh, C. Justin Lee   +11 more
wiley   +1 more source

Comparison of Wildtype and Recombinant Adeno-Associated Virus (AAV) Production Reveals Distinct Productivity and Content Ratio Profiles. [PDF]

Biotechnol J
Alfieri S, Lee KH.
europepmc   +1 more source

Efficacy and safety of Extended-Interval Rituximab vs. Standard MAINRITSAN Regimen for remission Maintenance in ANCA-Associated Vasculitis: A Multicenter Study

reservedBackground: Rituximab (RTX) achieved high remission-induction and sustained maintenance rates for patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) [1,2].
CAMPANIELLO, DEBORA
core  

Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation

Advanced Science, EarlyView.
Retrospective grid cells are identified in the medial entorhinal cortex, with spatial firing patterns that become most grid‐like when activity is projected onto recently traversed locations. Their coding loses spatial precision in darkness and is disrupted during assisted movement, indicating that entorhinal representations incorporate recent path ...
Ruojin Liu, Xin Yuan, Zilong He, Hong Jin, Jiayi Tian, Cong Chen, Yuanjing Liu, Xiang Zhang, Shidan Wen, Emilio Kropff, Chenglin Miao   +10 more
wiley   +1 more source