Results 201 to 210 of about 144,727 (384)

Parvalbumin Interneuron‐Dependent Hippocampal Neurogenesis Evoked by Prolonged Rhythmic Light Flicker

Advanced Science, EarlyView.
This study demonstrates that prolonged rhythmic 40 Hz light flicker enhances spatial learning by stimulating PV interneuron‐dependent neurogenesis. The light flicker selectively activates PV interneurons, which enhances GABAergic support for the integration of immature neurons in the adult dentate gyrus.
Hai Yan, Yunxuan Wang, Xufan Deng, Shiyu Wu, Yifan Pan, Jun Du, Mei Yu, Bo Liu, Huimei Wang, Zhengyu Zhang, Jinghong Chen, Shuifa Chen, Yizheng Wang, Tara Walker, Perry Bartlett, Jun Ju, Sheng‐Tao Hou   +16 more
wiley   +1 more source

Hepatic ENTPD5 Is Critical for Maintaining Metabolic Homeostasis and Promoting Brown Adipose Tissue Thermogenesis

Advanced Science, EarlyView.
ENTPD5‐mediated conversion of extracellular adenosine triphosphate to ADP of hepatocytes is critical for maintaining hepatic glucose/lipid metabolism and promoting brown adipose tissue thermogenesis via the inhibition of adrenomedullin expression and secretion.
Rufeng Ma, Song Hou, Rui Xiang, Wenjun Liu, Xin Li, Yujing Chi, Ming Xu, Haochen Yao, Jing Li, Jichun Yang   +9 more
wiley   +1 more source

906. Intramyocardial AAV Delivery of Heme Oxygenase-1 Gene Completely Protects Ischemic Myocardial Injury, Restores Left Ventricular Function and Prevents Remodelling [PDF]

, 2002

openalex   +1 more source

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

Advanced Science, EarlyView.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang, Zihan Li, Lei Wang, Haitao Zhang, Xiaoshan Yang, Lili Bao, Geng Dou, Lili Ren, Yajing Fu, Lan Li, Shengkai Gong, Yang Zhou, Feng Ding, Lu Yu, Haotian Luo, Yao Liu, Fuyang Zhang, Hui Yu, Siying Liu, Xueming Liu, Fulan Wei, Shiyu Liu   +21 more
wiley   +1 more source

Adeno-associated virus (AAV)-3-based vectors transduce haematopoietic cells not susceptible to transduction with AAV-2-based vectors

, 2000
Atsushi Handa, Shin‐ichi Muramatsu, Jianming Qiu, Hiroaki Mizukami, Kevin Brown   +4 more
openalex   +1 more source

HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF‐κB/SOD2 Signaling Pathway

Advanced Science, EarlyView.
HIGD1A maintains redox homeostasis in granulosa cells by modulating SOD2‐mediated dismutation of superoxide into H2O2, which is cleared by CAT and GPX enzymes. However, reduced HIGD1A activates the NF‐κB pathway and upregulates SOD2, leading to intracellular H2O2 accumulation due to impaired clearance.
Huiying Li, Siying Cai, Hongbei Mu, Tianli Chang, Xiaofei Wang, Tianyu Tang, Tengyun Dong, Yu Zhang, Ling Zhang, Huaibiao Li, Liquan Zhou, Wenpei Xiang   +11 more
wiley   +1 more source

Generation of light-producing somatic-transgenic mice using adeno-associated virus vectors [PDF]

, 2020
al., et, Cooper, Jonathan D., Karda, Rajvinder   +2 more
core   +1 more source

Development and Optimization of a Real-Time Quantitative PCR-Based Method for the Titration of AAV-2 Vector Stocks [PDF]

, 2002
Marlon R. Veldwijk, Julian Topaly, Stephanie Laufs, Ulrich R. Hengge, Frederik Wenz, W. Jens Zeller, Stefan Früehauf   +6 more
openalex   +1 more source

A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons

Neuron, 2016
D. Tervo, B. Hwang, Sarada Viswanathan, T. Gaj, Maria Lavzin, Maria Lavzin, K. Ritola, S. Lindo, Susan C. Michael, Elena Kuleshova, Elena Kuleshova, David S. Ojala, Cheng-Chiu Huang, C. Gerfen, J. Schiller, J. Schiller, J. Dudman, A. Hantman, L. Looger, D. Schaffer, A. Karpova   +20 more
semanticscholar   +1 more source

Pancreatic Cancer‐Derived Extracellular Vesicles Enriched with miR‐223‐5p Promote Skeletal Muscle Wasting Associated with Cachexia

Advanced Science, EarlyView.
EVs and EV‐microRNAs (miRNAs) mediate PDAC‐skeletal muscle communication. miR‐223‐5p reduces METTL14 transcription by targeting MAFA, which subsequently decreases m6A methylation in skeletal muscles, ultimately leading to muscle wasting. This study highlights the absorption of miRNA in PDAC‐derived EVs by skeletal muscles and reveals a previously ...
Kangjing Xu, Rongxi Shen, Li Zhang, Xuejin Gao, Xinbo Wang, Changhua Zhang, Xi Chen, Xinying Wang   +7 more
wiley   +1 more source