Results 211 to 220 of about 131,610 (332)

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

A rapid, visual, ultrasensitive and highly specific method for detecting adeno-associated virus 2020 based on the LAMP-CRISPR/Cas12a system. [PDF]

Poult Sci
Gong P, Tao D, Chen Q, Yang Y, Xie S, Chen X, Shi S, Wang Y, Wang L, Qian Y, Ye S.   +10 more
europepmc   +1 more source

AAV-based approaches to model and treat spinal muscular atrophy

, 2012
Adam K. Bevan
openalex   +1 more source

P.116 Improving the NeuroD1-AAV-based gene therapy intracerebral injection protocol for optimal neuronal recovery [PDF]

G Taheri, BA Masotti, Gustavo A. Garcı́a, R. Wan, M.G.F. Wilson, DJ Cook   +5 more
openalex   +1 more source

Macrophage–Derived Ferritin Exacerbates Silica‐Induced Pulmonary Fibrosis via PIK3R2‐Mediated Fibroblast Differentiation

Advanced Science, EarlyView.
This study identifies ferritin as a pivotal mediator of silica‐induced pulmonary fibrosis. Macrophage‐derived ferritin drives fibroblast‐to‐myofibroblast differentiation via the PIK3R2/SMAD pathway, while ferritin knockdown alleviates fibrosis. These findings define ferritin as both a biomarker and pathogenic driver, highlighting ferritin‐PIK3R2 ...
Liqun Wang, Xuxi Chen, Hongying Quan, Rui Qian, Shuyu Gong, Qiurong He, Ying Gao, Ajia Axi, Manyu Zhao, Qin Zhang, Ling Zhang, Lijun Peng, Xin Sun, Ben Zhang, Yuqin Yao   +14 more
wiley   +1 more source

ANCA-associated vasculitis in the United Arab Emirates: a 17-year case series with review from Gulf literature. [PDF]

Ann Saudi Med
Shahrour H, Luqman N, AlKindi F, Khan M, Al Nokhatha SA.   +4 more
europepmc   +1 more source

86. AAV vs HDAd Viral Vectors as Promising Agents for the Biopump Therapeutic System [PDF]

, 2014

openalex   +1 more source

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source

Repeat kidney biopsy reveals new-onset IgA nephropathy in a patient with ANCA-associated vasculitis. [PDF]

CEN Case Rep
Iwami S, Eriguchi M, Kosugi T, Furuyama R, Kitamura S, Tanabe K, Matsui M, Samejima KI, Tsuruya K.   +8 more
europepmc   +1 more source

Risk factors for severe COVID-19 infection and the impact of COVID-19 infection on disease progression among patients with AAV [PDF]

Chen Wang, Zhiying Li, Guiping Jiang, Ming‐Hui Zhao, Min Chen   +4 more
openalex   +1 more source