Results 231 to 240 of about 79,958 (292)

Technical and biological sources of noise confound multiplexed enhancer AAV screening. [PDF]

Nat Commun
Hunker AC, Mich JK, Taskin N, Torkelson A, Cardenas T, Lalanne JB, Mahoney JT, Bertagnolli D, Chakka AB, Chakrabarty R, Donadio NP, Ferrer R, Gasperini M, Goldy J, Guzman J, Jin K, Khem S, Kutsal R, Martinez RA, Newman D, Pena N, Rimorin C, Rocha D, Shapovalova NV, Tieu M, Weed N, Zhou T, Hodge R, Yao S, Shendure J, Smith KA, Lein ES, Tasic B, Levi BP, Ting JT.   +34 more
europepmc   +1 more source

AAV-mediated gene transfer for Mucopolysaccharidosis VI

, 2009
AURICCHIO, ALBERTO
core  

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source

Projection-defined hypothalamic outputs differentially regulate thermogenesis and lipolysis. [PDF]

Proc Natl Acad Sci U S A
Min H, Zheng Q, Yang Y.
europepmc   +1 more source

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu, David A. Alvarez Rodriguez, Noah Gould, Alexander R. Ivanov, Kevin Jooß, Liangliang Sun   +5 more
wiley   +1 more source

Upregulated PKM2 Protects Dopaminergic Neurons From Oxidative Damage Through Nrf2 Transactivation in an MPTP-Induced Mouse Model of Parkinson's Disease. [PDF]

CNS Neurosci Ther
Mei M, Miao QQ, Li MK, Wang HR, Ding JH, Hu G, Wei Y.   +6 more
europepmc   +1 more source

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

A female-specific role for Slit1 in prenatal stress-induced depression vulnerability. [PDF]

Neurotherapeutics
Xu K, Chen T, Yang Y, Liu W, Guo H, Gong Z, Ma X, Liu J, Lu Y, Zhang H, Fan X, Li H, Zhu Z.   +12 more
europepmc   +1 more source

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

Medicine Bulletin, EarlyView.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang, Changling Xu, Jiangang Fan, Renjie Chai   +3 more
wiley   +1 more source

AAV2-associated liver injury across infection and gene therapy: converging genomic signals. [PDF]

Front Immunol
Chen Y, Zhu Q, Yuan N, Jin D, Zhu Z, Chen F.   +5 more
europepmc   +1 more source