Results 251 to 260 of about 89,643 (298)

AAV-ID: A Rapid and Robust Assay for Batch-to-Batch Consistency Evaluation of AAV Preparations [PDF]

Molecular Therapy, 2017
International audienceAdeno-associated virus (AAV) vectors are promising clinical candidates for therapeutic gene transfer, and a number of AAV-based drugs may emerge on the market over the coming years.
Luk H Vandenberghe, Magalie Penaud-Budloo, Eva Andres-Mateos   +2 more
exaly   +2 more sources

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Integration of Adeno-Associated Virus (AAV) and Recombinant AAV Vectors

Annual Review of Genetics, 2004
▪ Abstract  The driving interest in adeno-associated virus (AAV) has been its potential as a gene delivery vector. The early observation that AAV can establish a latent infection by integrating into the host chromosome has been central to this interest. However, chromosomal integration is a two-edged sword, imparting on one hand the ability to maintain
Samuel M Young, Douglas M McCarty, R Jude Samulski   +2 more
exaly   +3 more sources

Recombinant AAV Production

The insect cell-baculovirus expression vector (IC-BEV) platform has enabled small research-scale and large commercial-scale production of recombinant proteins and therapeutic biologics including recombinant adeno-associated virus (rAAV)-based gene delivery vectors.
Pranav R H, Joshi, Alina, Venereo-Sanchez   +1 more
openaire   +2 more sources

Recombinant AAV Purification

Purification of rAAV is a crucial unit operation of the AAV production process. It enables the capture of AAV and removal of contaminants such as host cell proteins, host cell DNA, and other cell culture-related impurities. Here we describe the purification of rAAV produced in insect cells Sf9/rBEV by immuno-affinity capture chromatography.
Pranav R H, Joshi, Alina, Venereo-Sanchez   +1 more
openaire   +2 more sources

Directed Evolution of a Family of AAV Capsid Variants Enabling Potent Muscle-Directed Gene Delivery Across Species

Cell, 2021
Alexandra Stanton, Alan H. Beggs, Behzad Moghadaszadeh   +2 more
exaly  

AAV-Based in Vivo Gene Therapy for Neurological Disorders

Nature Reviews Drug Discovery, 2023
Steven J Gray, Jessica A Herstine, Allison Bradbury   +2 more
exaly  

AAV

2006
  +4 more sources

ENGINEERING AAV

2020
MCGOVERN KYLE, OJALA DAVID
openaire   +3 more sources

AAV

2015
openaire   +2 more sources

Identification of Mouse AAV Capsid-Specific CD8+ T Cell Epitopes

Molecular Therapy, 2005
Hildegund C.J. Ertl, Katherine A. High, Denise E Sabatino   +2 more
exaly