Results 281 to 290 of about 131,610 (332)

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Global and Selective Effects of Auditory Attention on Arousal: Insights From Pupil Dilation. [PDF]

J Cogn
Grandjean A, Hoyer RS, Mathieu A, Caclin A, Moulin A, Bidet-Caulet A.   +5 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Astrocytic TCF7L2 Impacts Brain Osmoregulation and Restricts Neuronal Excitability. [PDF]

Glia
Popek M, Goryca K, Adamska D, Urban-Ciećko J, Hryniewiecka K, Lipiec M, Krawczyk TG, Rafalko K, Ławicka A, Liddelow SA, Szewczyk LM.   +10 more
europepmc   +1 more source

Clock gene dysregulation in epilepsy: A systematic review

Epilepsia Open, EarlyView.
Abstract Objective Epileptic seizures show a rhythmic pattern, being more frequent at particular times of the day (e.g., only occurring during sleep), suggesting a role of the circadian rhythm. Clock genes regulate the circadian rhythm and might be involved in the pathophysiology of epilepsy.
Guilherme Fernandes‐Campos, Arjune Sen, Francesca Panin, Krithika Sundararaman   +3 more
wiley   +1 more source

Electroacupuncture alleviates blood-brain barrier disruption and neuroinflammation via astrocytic MC4R in a mouse model of multiple sclerosis. [PDF]

J Neuroinflammation
Wang Y, Ma X, Qiao Z, Zhang X, Ji J, Zhang S, Zhuang W, Wu J, Li A, Wang C, Xiu X, Wang J, Meng Y, Huang W, Lang X, Liu X, Sun B, Li H, Liu Y.   +18 more
europepmc   +1 more source

Sleep enhances gamma oscillations in the seizure onset zone and broadband activity in the irritative zone of focal cortical dysplasia

Epilepsia Open, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) is a leading cause of drug‐resistant epilepsy and is associated with sleep‐related seizures, yet the underlying electrophysiological mechanisms during different brain states remain poorly understood. We investigated whether fast oscillations (FOs) within the seizure onset zone (SOZ) and irritative zone (
Mohammad F. Khazali, Nina Schwoon, Armin Brandt, Matthias Dümpelmann, Yiwen Li Hegner, Nicolas Roehri, Dirk‐Matthias Altenmüller, Victoria San Antonio‐Arce, Peter C. Reinacher, Julia M. Nakagawa, Soroush Doostkam, Theo Demerath, Horst Urbach, Andreas Schulze‐Bonhage, Marcel Heers   +14 more
wiley   +1 more source

Intrahepatic Lymphangiogenesis Is Associated with Early Post-Hepatectomy Liver Regeneration, in Part via IL-6/STAT3 Signaling. [PDF]

Int J Med Sci
Xie S, Fan X, Liu Y, Li H, Zhou C, Guo C, Tang X, Ming Y, Zhang P.   +8 more
europepmc   +1 more source

Age-Associated Dysregulation of Postsynaptic Mitochondria Perturbs Reinnervation Kinetics. [PDF]

Aging Cell
Guzman SD, Fraczek PM, Itsani K, Furati EK, Juros D, Kenney G, Valdez G, Chakkalakal JV, Aguilar CA.   +8 more
europepmc   +1 more source

FABP4-mediated lipid droplet accumulation drives epithelial-mesenchymal transition and aggravates alveolar epithelial barrier disruption. [PDF]

Clin Transl Med
Shen Z, Qi Y, Chu M, Wu M, Feng C, Li X, Liu Z, Si L, Wang Y, Zhang J, Lu X, Lu P.   +11 more
europepmc   +1 more source