Results 131 to 140 of about 326,770 (247)

Adeno-associated virus (AAV)-3-based vectors transduce haematopoietic cells not susceptible to transduction with AAV-2-based vectors

, 2016
Although adeno-associated virus (AAV)-2 has a broad tissue-host range and can transduce a wide variety of tissue type, some cells, such as erythro-megakaryoblastoid cells, are non-permissive and appear to lack the AAV-2 receptor. However, limited studies

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List of AAV vectors, multiplicity of infection (MOI) values and cell lines used for the transduction inhibition assay.

, 2019
List of AAV vectors, multiplicity of infection (MOI) values and cell lines used for the transduction inhibition assay.
A. Katrin Helfer-Hungerbuehler (3473333), Eva Boenzli (298295), Pengfei Li (290581), Regina Hofmann-Lehmann (374215)   +3 more
core   +1 more source

Nuclear Translocation of PFKFB3 Promotes Disuse‐Induced Muscle Atrophy via Scaffolding Nedd4‐Mediated JunB Ubiquitination

Advanced Science, EarlyView.
Disuse‐induced muscle atrophy is driven by a non‐metabolic, nuclear function of the enzyme PFKFB3. Acting as a scaffold, PFKFB3 facilitates Nedd4‐mediated ubiquitination and degradation of the anti‐atrophy transcription factor JunB. Inhibiting this novel PFKFB3–Nedd4–JunB signaling axis stabilizes JunB and alleviates muscle wasting, revealing a highly ...
Mengjun Ma, Yinliang Liu, Wangchang Wu, Biao Yang, Jiahao Zhuang, Haoye Yu, Rujia Mi, Yixuan Lu, Wen Yang, Hanting Yi, Chenglong Yuan, Yinfeng Gu, Hongyu Li   +12 more
wiley   +1 more source

Mosaic AAV mediates efficient transduction across the central and peripheral nervous systems

Molecular Brain
Adeno-associated virus (AAV) is a promising vector for neurological gene therapy, yet engineered serotypes are restricted to targeting either the central or peripheral nervous system (CNS or PNS). To overcome this limitation, we generated AAV with mosaic
Min Jiang, Wenqing Yin, Xiaolu Mo, Zhounan Wang, Mengsheng Qiu, Zhong-Min Dai   +5 more
doaj   +1 more source

Dual AAV vectors for efficient delivery of large transgenes

Despite their limited cargo capacity (
Biel, Martin, Gavrilov, Zoran; https://orcid.org/, Becirovic, Elvir; https://orcid.org/, Mehlfeld, Verena, Riedmayr, Lisa M., Otify, Dina Y., Gandor, Catharina Leila Angeles; https://orcid.org/, Szalontai, Balint, Mittas, David M., Ucambarlic, Emina, Weber, Valentin J.; https://orcid.org/, Heigl, Thomas; https://orcid.org/   +11 more
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Retinal gene therapy for Stargardt disease with dual AAV intein vectors is both safe and effective in large animal models [PDF]

Retinal gene therapy using dual adeno-associated viral (AAV) intein vectors can be applied to genetic forms of blindness caused by mutations in genes with coding sequences that exceed single AAV cargo capacity, such as Stargardt disease (STGD1), the most
Lagutina, Irina, Memon, Muhammad A, Shams, N., Surace, Enrico M., Elmi, A., Duchi, Roberto, Lupo, Mariangela, Trapani, I., Ferla, Rita, Duchi, R., Simonelli, Francesca, Gesualdo, C., Tiberi, Paola, Toomes, Carmel, Rossi, S., Pugni, Eugenio, Tiberi, P., Ventrella, D., Bacci, Maria L, Lupo, M., Ventrella, Domenico, Simonelli, F., Xu, T., Molday, R.S., Bacci, Maria L., Rossi, Settimio, Memon, Muhammad A., Fioretto, Federica, Surace, Enrico M, Toomes, C., Elmi, Alberto, Auricchio, Alberto, Trapani, Ivana, Auricchio, A., Gesualdo, Carlo, Bacci, M.L., Memon, M.A., Pugni, E., Galli, Cesare, Perota, A., Xu, Tongzhou, Lagutina, I., McClinton, B., Molday, Robert S, Ferla, R., Fioretto, F., Surace, E.M., Shams, Naveed, Perota, Andrea, McClinton, Benjamin, Molday, Robert S., Galli, C.   +51 more
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Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

AAV-Jahresbericht

AAV-JAHRESBERICHT AAV-Jahresbericht (Rights ...

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FBP1‐Mediated Compartmentalization of Glycolytic Enzyme Complexes Suppresses PKM2 Function to Ameliorate MASLD Progression

Advanced Science, EarlyView.
In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang, Yiping Tang, Na Li, Xuening Dai, Jing Wu, Bin Xue, Yuxin Chen, Jingzi Zhang, Lingdong Kong, Chaojun Li, Lei Fang   +10 more
wiley   +1 more source