Results 1 to 10 of about 823,189 (262)

Co-transduction of dual-adeno-associated virus vectors in the neonatal and adult mouse utricles

Frontiers in Molecular Neuroscience, 2022
Adeno-associated virus (AAV)-mediated gene transfer is an efficient method of gene over-expression in the vestibular end organs. However, AAV has limited usefulness for delivering a large gene, or multiple genes, due to its small packaging capacity (<
Zhong-Rui Chen, Zhong-Rui Chen, Jing-Ying Guo, Jing-Ying Guo, Lu He, Lu He, Shan Liu, Shan Liu, Jun-Yi Xu, Jun-Yi Xu, Zi-Jing Yang, Zi-Jing Yang, Wei Su, Wei Su, Ke Liu, Ke Liu, Shu-Sheng Gong, Shu-Sheng Gong, Guo-Peng Wang, Guo-Peng Wang   +19 more
doaj   +1 more source

Telomerase Reverse Transcriptase Increases Proliferation and Lifespan of Human NK Cells without Immortalization

Biomedicines, 2021
NK cells are the first line of defense against viruses and malignant cells, and their natural functionality makes these cells a promising candidate for cancer cell therapy.
Maria A. Streltsova, Maria O. Ustiuzhanina, Eugene V. Barsov, Sofya A. Kust, Rodion A. Velichinskii, Elena I. Kovalenko   +5 more
doaj   +1 more source

Genetic Engineering and Enrichment of Human NK Cells for CAR-Enhanced Immunotherapy of Hematological Malignancies

Frontiers in Immunology, 2022
The great clinical success of chimeric antigen receptor (CAR) T cells has unlocked new levels of immunotherapy for hematological malignancies. Genetically modifying natural killer (NK) cells as alternative CAR immune effector cells is also highly ...
Maren Soldierer, Arthur Bister, Arthur Bister, Corinna Haist, Corinna Haist, Aniththa Thivakaran, Sevgi Can Cengiz, Stephanie Sendker, Nina Bartels, Antonia Thomitzek, Denise Smorra, Maryam Hejazi, Markus Uhrberg, Kathrin Scheckenbach, Cornelia Monzel, Constanze Wiek, Dirk Reinhardt, Naghmeh Niktoreh, Helmut Hanenberg, Helmut Hanenberg   +19 more
doaj   +1 more source

Supporting Student Transduction of Meanings Across Modes in Primary School Astronomy

Frontiers in Communication, 2022
The multimodal nature of knowledge development and learning in science is now increasingly recognized. While researchers have focused on identifying how different representational modes afford meaning-making, the question of how students are guided to ...
Russell Tytler, Vaughan Prain
doaj   +1 more source

Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer

Journal of Experimental & Clinical Cancer Research, 2019
Background Despite the increasing progress in targeted and immune based-directed therapies for other solid organ malignancies, currently there is no targeted therapy available for TNBCs.
Murugan Kalimutho, Debottam Sinha, Deepak Mittal, Sriganesh Srihari, Devathri Nanayakkara, Shagufta Shafique, Prahlad Raninga, Purba Nag, Kate Parsons, Kum Kum Khanna   +9 more
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What Do We Hear When We Hear Microbe Sounds

Pulse, 2022
The concept of the Anthropocene, based on the premise that mankind has become a major geological force in its own right, has grown into a central theme with issues such as ecological crisis, climate change, or sustainable futures.
Emre Sünter
doaj   +1 more source

The Age of Phage: Friend or Foe in the New Dawn of Therapeutic and Biocontrol Applications?

Pharmaceuticals, 2021
Extended overuse and misuse of antibiotics and other antibacterial agents has resulted in an antimicrobial resistance crisis. Bacteriophages, viruses that infect bacteria, have emerged as a legitimate alternative antibacterial agent with a wide scope of ...
Ahmad Y. Hassan, Janet T. Lin, Nicole Ricker, Hany Anany   +3 more
doaj   +1 more source

Comparison of the Transduction Capacity of AAV5 and AAV PHP.eB Serotypes in Hippocampus Astroglia

Neuroglia, 2023
In the present study, we compared the astrocyte-transducing potential of the relatively novel engineered AAV PHP.eB serotype and the well-examined conventional AAV5 serotype.
Anastasia Borodinova, Victor Ierusalimsky, Pavel Balaban   +2 more
doaj   +1 more source

Isolation of tissue-resident endothelial stem cells and their use in regenerative medicine

Inflammation and Regeneration, 2019
Background During sprouting angiogenesis, stalk cells, localized behind tip cells, generate endothelial cells (ECs) for the elongation of new vessels.
Tomohiro Iba, Hisamichi Naito, Shota Shimizu, Fitriana Nur Rahmawati, Taku Wakabayashi, Nobuyuki Takakura   +5 more
doaj   +1 more source

Modeling the Electrostatic Actuation of Nanomechanical Pillar Dimers

Frontiers in Mechanical Engineering, 2021
With their unparalleled mass sensitivity, enabling single-molecule mass spectrometry, nanomechanical resonators have the potential to considerably improve existing sensor technology.
Andreas Kainz, Andreas Kainz, Roman Beigelbeck, Silvan Schmid   +3 more
doaj   +1 more source