Results 141 to 150 of about 32,863 (259)

Variation of VP2 stoichiometry and deamidation of VP1 during production and their impacts on the transduction efficiency of AAV vectors. [PDF]

Mol Ther Methods Clin Dev
Maruno T, Fukuhara M, Tsunaka Y, Matsushita A, Hirohata K, Bandoh K, Onaka M, Shibuya R, Yamaguchi Y, Nishiumi H, Nagashima Y, Higo D, Kuwahara T, Ueno T, Maeda M, Kanai-Bai G, Yamano-Adachi N, Torisu T, Omasa T, Uchiyama S.   +19 more
europepmc   +1 more source

Strategies to improve safety profile of AAV vectors. [PDF]

Front Mol Med, 2022
Suoranta T, Laham-Karam N, Ylä-Herttuala S.   +2 more
europepmc   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Redosing of AAV vectors in the brain after intracranial injections: Low-ish hanging fruit? [PDF]

Mol Ther Methods Clin Dev
Maguire CA.
europepmc   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source

Specific targeting of brain endothelial cells using enhancer AAV vectors. [PDF]

Neuron
Velazquez-Rivera E, Dey O, Kim NS, Cao W, Ye Q, Gao P, Thai A, Nguyen JK, Zhang H, Ting JT, Gopi M, Ren B, Holmes TC, Xu X.   +13 more
europepmc   +1 more source

Genome‐wide network analysis identifies the lncRNA‐92467/miR‐205‐5p/PTPRM/CAMs axis in a rat model of hypoxic pulmonary hypertension

Animal Models and Experimental Medicine, EarlyView.
The pathogenesis of hypoxic pulmonary hypertension (HPH) remains unclear. In this study, we explored its key regulatory mechanisms using animal models, RNA sequencing, and cellular assays. We found that lncRNA‐92467 functions as a ceRNA, binding miR‐205‐5p, and thereby upregulating PTPRM, inhibiting abnormal proliferation and migration of endothelial ...
Yan‐Ying Shen, Yi‐Bing Chen, Xin Li, Xiang Xu, Ge Guo, Han‐Lu Li, Yong‐Ming Yao, Chun‐Lei Liu   +7 more
wiley   +1 more source

Directed evolution of liver-detargeted AAV vectors for systemic gene delivery to skeletal muscle and heart. [PDF]

Mol Ther Methods Clin Dev
Firnberg E, Tejada SKS, Yost SA, Giles AR, Choi H, Foltz SJ, Qian R, Smith JB, Heithoff B, Elliott K, David Hou CF, Bernstein AD, Karumuthil-Melethil S, Chen VS, Mayer A, Mercer AC, Kaelber JT, Liu Y, Danos O.   +18 more
europepmc   +1 more source

Immunogenicity of Recombinant Adeno-Associated Virus (AAV) Vectors for Gene Transfer. [PDF]

BioDrugs, 2023
Arjomandnejad M, Dasgupta I, Flotte TR, Keeler AM.   +3 more
europepmc   +1 more source

Ac‐SDKP modulates apoptosis via HSP27 and the FAS/FASL and mitochondrial axes

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of Ac‐SDKP regulating the FAS/FASL and mitochondrial apoptosis pathways via HSP27. Ac‐SDKP inhibits HSP27 expression, activates the FAS/FASL pathway and Caspase‐3 signaling, increases Caspase‐8 and Caspase‐3 expression, and induces cell apoptosis.
Wenxin Guo, Jinyin Yan, Wenli Li, Jin Wang, Lu Liu, Chengmei Zhang, Wei Cao, Shanshan Yao, Haibo Gong, Yi He, Zihan Zhou, Siyan Chen, Li Feng, Haijing Deng   +13 more
wiley   +1 more source