Results 181 to 190 of about 32,863 (259)

Identifying adeno-associated virus (AAV) vectors that efficiently target high grade glioma cells, for in vitro monitoring of temporal cell responses. [PDF]

FEBS Open Bio
Sarker FA, Chen Y, Westhaus A, Lisowski L, O'Neill GM.   +4 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Chemical approaches to probe and engineer AAV vectors.

Nanoscale
Pham Q, Glicksman J, Chatterjee A.
europepmc   +1 more source

A novel approach to quantitate biodistribution and transduction of adeno-associated virus gene therapy using radiolabeled AAV vectors in mice. [PDF]

Mol Ther Methods Clin Dev
Wang H, Li R, Sadekar S, Kamath AV, Shen BQ.   +4 more
europepmc   +1 more source

Bidirectional Wireless Power Transfer for Electric Vehicle Energy Systems Integrating Modelling, Intelligent Control, Communication and Cybersecurity: A Review

Energy Science &Engineering, EarlyView.
This graphical abstract illustrates the evolution of wireless electric vehicle charging from unidirectional wireless power transfer to bidirectional wireless power transfer (BWPT) and toward future intelligent, autonomous wireless energy systems.
P. V. Elumalai, Yuvaraja Shanmugam, A. Vivek Anand, Mesith Chaimanee, Choon Kit Chan, S. Prabhakar, R. Narayanamoorthi   +6 more
wiley   +1 more source

Comprehensive analysis of off-target and on-target effects resulting from liver-directed CRISPR-Cas9-mediated gene targeting with AAV vectors. [PDF]

Mol Ther Methods Clin Dev
Singh K, Fronza R, Evens H, Chuah MK, VandenDriessche T.   +4 more
europepmc   +1 more source

Enhancing Optogenetics‐Based Cancer Therapy Via Nanotechnology

Exploration, EarlyView.
Nanotechnology enhances optogenetics‐based cancer therapy through improved delivery systems and non‐invasive optical regulation. It further enables precise and programmable control of optogenetic living therapeutics for localized antitumor responses.
Honggang Shen, Wenzhe Yi, Rongzhang Li, Shuangshuang Hu, Xindi Qian, Dan Yan, Qian Zou, Guanru Wang, Yaping Li   +8 more
wiley   +1 more source

Optimization of AAV vectors for transactivator-regulated enhanced gene expression within targeted neuronal populations. [PDF]

iScience
Kojima L, Seiriki K, Rokujo H, Nakazawa T, Kasai A, Hashimoto H.   +5 more
europepmc   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, EarlyView.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Hyperoside alleviates endometrial stromal cell senescence in unexplained recurrent spontaneous abortion via DHX9‐mediated R‐loop resolution

iMeta, EarlyView.
This study suggests that the food‐derived flavonoid hyperoside may act as a natural DExH‐box helicase 9 (DHX9) modulator, directly targeting Thr419 of DHX9 to help resolve pathological R‐loop accumulation. Consequently, it suppresses cyclic GMP‐AMP synthase‐stimulator of interferon genes (cGAS‐STING)‐driven endometrial stromal senescence and restores ...
Yuepeng Jiang, Hongli Zhao, Xinyi Ding, Haoling Zhang, Yadong Guo, Yiming Ma, Lingyi Cai, Qingnan Fan, Ruisi Peng, Fuyuan Yang, Doblin Sandai, Xianling Cao, Jiali Yao, Wenyi Wang, Zhiheng Lin, Wangzheqi Zhang, Jialin He, Aihua Zhang, Xiaoxuan Zhao   +18 more
wiley   +1 more source