Results 31 to 40 of about 326,770 (247)

A strategy for high antibody expression with low anti-drug antibodies using AAV9 vectors

Frontiers in Immunology, 2023
IntroductionUse of adeno-associated virus (AAV) vectors is complicated by host immune responses that can limit transgene expression. Recent clinical trials using AAV vectors to deliver HIV broadly neutralizing antibodies (bNAbs) by intramuscular ...
Meredith E. Davis-Gardner, Jesse A. Weber, Jun Xie, Jun Xie, Katja Pekrun, Eric A. Alexander, Kim L. Weisgrau, Jessica R. Furlott, Eva G. Rakasz, Mark A. Kay, Guangping Gao, Guangping Gao, Michael Farzan, Matthew R. Gardner, Matthew R. Gardner   +14 more
doaj   +1 more source

Reengineered AAV Vectors: Old Dog, New Tricks [PDF]

, 2010
Adeno-Associated Viral (AAV) vectors have emerged in recent years as powerful tools for therapeutic gene transfer. Successes in clinical trials and the discovery of several hundreds of naturally occurring AAV isolates have triggered efforts to understand
Asokan, Aravind
core   +1 more source

Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution? [PDF]

, 2009
The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based
Anja Ehrhardt, Nadine Müther, Ehrhardt, Anja, Nadja Noske, Müther, Nadine, Noske, Nadja, Nadine Müther   +6 more
core   +1 more source

Human Immune Responses to Adeno-Associated Virus (AAV) Vectors

, 2020
International audienceRecombinant adeno-associated virus (rAAV) vectors are one of the most promising in vivo gene delivery tools. Several features make rAAV vectors an ideal platform for gene transfer.
Ronzitti, Giuseppe, Mingozzi, Federico, Gross, David-Alexandre   +2 more
core   +1 more source

AAV genome modification for efficient AAV production

Heliyon, 2023
The adeno-associated virus (AAV) is one of the most potent vectors in gene therapy. The experimental profile of this vector shows its efficiency and accepted safety, which explains its increased usage by scientists for the research and treatment of a ...
Walaa Asaad, Polina Volos, Denis Maksimov, Elena Khavina, Andrei Deviatkin, Olga Mityaeva, Pavel Volchkov   +6 more
doaj   +1 more source

Perinatal Gene Transfer to the Liver [PDF]

, 2011
The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within
Buckley, SM, Ward, N.J., Buckley, S.M.K., Ward, NJ, Chan, J.K.Y., Waddington, S.N., Rahim, A.A., Waddington, SN, Rahim, AA, Chan, JK, Mckay, T.R., Howe, S.J., Howe, SJ, McKay, TR, Natalie J. Ward, Ahad A. Rahim, Steven J. Howe, Jerry K.Y.Chan, Suzanne M.K. Buckley, Simon N. Waddington, Tristan R. McKay   +20 more
core   +1 more source

AAV VECTORS VACCINES AGAINST INFECTIOUS DISEASES [PDF]

, 2014
Since their discovery as a tool for gene transfer, vectors derived from the Adeno-Associated Virus (AAV) have been used for gene therapy applications and attracted scientist to this field for their exceptional properties of efficiency of in vivo gene ...
Salvetti, Anna, Karen Nieto, Nieto, Karen, Anna Salvetti, Karen eNieto, Anna eSalvetti   +5 more
core   +1 more source

Transduction and Genome Editing of the Heart with Adeno-Associated Viral Vectors Loaded onto Electrospun Polydioxanone Nonwoven Fabrics

Biomolecules
In this study, we introduce electrospun polydioxanone (PDO) nonwoven fabrics as a platform for the delivery of adeno-associated virus (AAV) vectors for transduction and genome editing by adhering them to organ surfaces, including the heart.
Kotoko Furuno, Keiichiro Suzuki, Shinji Sakai   +2 more
doaj   +1 more source

Targeting AAV vectors

Molecular Therapy, 2003
One of the many hurdles that face gene therapists is the requirement to optimize gene delivery systems in such a way that both efficient and selective transgene production is achieved in vivo within a chosen cell or tissue. Exploiting native vector tropism can sometimes achieve this goal irrespective of additional modifications. For example, adenoviral
openaire   +2 more sources

The state of the art of adeno-associated virus-based vectors in gene therapy

Virology Journal, 2007
The adeno-associated virus (AAV) has rapidly gained popularity in gene therapy since the establishment of the first AAV2 infectious clone, in 1982, due to some of their distinguishing characteristics such as lack of pathogenicity, wide range of ...
Nardi Nance, Coura Renata
doaj   +1 more source