Results 51 to 60 of about 15,511 (169)
, 2015 A. Mean abacavir ELISpot responses for HLA B*57:01 positive or negative individuals, that were either abacavir naïve or treatment experienced. B Abacavir ELISpot responses in patch test confirmed abacavir HSR patients plotted relative to time from first ...
Niamh M. Keane (691987) +15 more
core +1 more source
Frontiers in Pharmacology, 2020 IntroductionCertain HLA variants are associated with an increased risk of hypersensitivity reactions to specific drugs. Both the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Dutch Pharmacogenetics Working Group (DPWG) have issued ...
Lisanne E. N. Manson +5 more
doaj +1 more source
Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper
Allergy, EarlyView.ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres +19 more
wiley +1 more source
Abacavir and the altered peptide repertoire model: Clinical implications [PDF]
, 2012 Structural and biochemical studies showing that abacavir binds non-covalently to the floor of the peptide binding groove of HLAB* 5701 with exquisite specificity to alter the self-peptides that load on the molecule to be presented to the immune system ...
Phillips, E., Mallal, S.
core
Frontiers in Pharmacology, 2021 Given the high prevalence of multidrug-resistant (MDR)-TB in high HIV burden settings, it is important to identify potential drug-drug interactions between MDR-TB treatment and widely used nucleoside reverse transcriptase inhibitors (NRTIs) in HIV ...
Louvina E. van der Laan +11 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Achieving minimum unbound drug concentration in plasma above in vitro EC90 is a common antiviral pharmacokinetic/pharmacodynamic (PK/PD) target. However, it often overlooks restricted distribution into target sites like the central nervous system (CNS), where a trough concentration above 1 × EC90 is needed.
Daan W. van Valkengoed +6 more
wiley +1 more source
High sensitivity of human leukocyte antigen–B*5701 as a marker for immunologically confirmed abacavir hypersensitivity in white and black patients [PDF]
, 2008 Background. Although the human leukocyte antigen (HLA)-B*5701 is highly associated with a hypersensitivity reaction (HSR) to abacavir (ABC), variable sensitivities have been reported when clinical data alone have been used to define an ABC HSR.
Stancil, B. +13 more
core
HIV Medicine, EarlyView.Abstract Objectives Children and adolescents living with HIV previously taking ritonavir‐boosted lopinavir (LPV/r)‐based antiretroviral therapy (ART) have been programmatically transitioned to dolutegravir (DTG)‐based regimens in many country programs.
Jacob Blankenberger +14 more
wiley +1 more source
Кубанский научный медицинский вестник, 2018 Aim.To develop a technique for the detection and separation of abacavir, lamivudine, zidovudine, both individually and combined with adaptol, azaleptin, analgin, amitriptyline, haloperidol, melipramine, neuleptil, phenobarbital, fluoxetine, and ...
YU. A. GONCHIKOVA +2 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
wiley +1 more source