Results 61 to 70 of about 15,511 (169)

Virus‐specific alterations in placental structure and transporter expression following maternal arbovirus infection

The Journal of Physiology, EarlyView.
Abstract figure legend Arboviruses induce virus‐specific alterations in placental structure and functional markers. Chikungunya virus (CHIKV) exposure was associated with reduced syncytiotrophoblast and syncytial knot areas, increased cytotrophoblast proliferation (Ki‐67) and thyroid transporter (MCT8) expression, reduced protective (P‐gp and BCRP ...
Cherley B. V. Andrade, Enrrico Bloise, Natália L. Silva, Jair R. S. Braga, Sharton V. A. Coelho, Veronica M. O. Nascimento, Guinever E. Imperio, Camila O. S. Nunes, Antônio J. L. A. Cunha, Marcelo A. Pascoal‐Xavier, Luciana B. Arruda, Arnaldo Prata‐Barbosa, Kristin L. Connor, Tania M. Ortiga‐Carvalho   +13 more
wiley   +1 more source

Understanding Drivers of Loss to Follow‐Up in HIV Care in Oromia Regional State, Ethiopia: A Qualitative Grounded Theory

Health Science Reports, Volume 9, Issue 11, November 2026.
ABSTRACT Background Despite significant advancements in antiretroviral therapy (ART), loss to follow‐up (LTFU) remains a critical challenge in HIV care, particularly in low‐resource settings like Ethiopia. LTFU contributes to increased morbidity and mortality rates, heightened transmission risks, and treatment failure.
Fikru Tafese, Matebu Gezahegn, Zeriun Kura, Eshetu Alemayehu, Yadeta Ayana, Chala Bafikadu, Gusha Belako, Tesfaye Zerfu, Birhanu Kenate Sori, Yadeta Dassie, Firaol Bekele, Negash Sime, Tizta Tilahun Degfie, Daniel Yilma, Yohannes Ejigu, Yohannes Kebede, Mirkuzie Woldie   +16 more
wiley   +1 more source

Mutations in HIV-1 reverse transcriptase during therapy with abacavir, lamivudine and zidovudine in HIV-1-infected adults with no prior antiretroviral therapy

, 2002
Objective: To evaluate HIV-1 reverse transcriptase (RT) drug resistance in patients receiving abacavir, lamivudine and zidovudine therapy. Methods: In a randomized, double-blind study, 173 antiretroviral treatment-naive HIV-1-infected adults received ...
Pulido Ortega, Federico, Lafon, Steve, Ait-Khaled, Mounir, Rubio García, Rafael   +3 more
core   +2 more sources

Medicinal Chemistry Aspects of Thiazole and Thiazolidine Derivatives as Fundamental Building Blocks to Design New NNRTIs Against HIV‐1 Reverse Transcriptase

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
HIV‐1 reverse transcriptase (HIV‐1 RT) is a polymerase enzyme and a key target in HIV‐1 therapy. The discovery of selective HIV‐1 RT inhibitors has highlighted thiazole scaffolds and their derivatives, thiazolidine‐2‐one and thiazolidine‐2,4‐dione, as promising structures for the rational design of novel non‐nucleoside reverse transcriptase inhibitors (
José Arion da Silva Moura, Matheus Vinicius Guimarães de Melo, Diane Regis Santos do Nascimento, Thaynara Paula Warren Bezerra, Mathieu Métifiot, Patricia Recordon‐Pinson, Maira Galdino da Rocha Pitta, Marina Galdino da Rocha Pitta, Michelly Cristiny Pereira, Marie‐Line Andreola   +9 more
wiley   +1 more source

It’s about time: The association between abacavir and cardiovascular disease

Antiviral Therapy
Data from the REPRIEVE trial have been used to study the association between treatment with abacavir and cardiovascular disease in people with HIV. Past exposure to abacavir before the trial was found to be just as risky as exposure during the trial ...
Jim Young, Patrick R. Lawler, Erica E. M. Moodie, Heiner C. Bucher, Marina B. Klein   +4 more
doaj   +1 more source

Severe abacavir hypersensitivity reaction in a patient with human immunodeficiency virus infection: a case report

Journal of Medical Case Reports, 2022
Background Abacavir is a nucleoside reverse transcriptase inhibitor that is used as a component of the antiretroviral treatment regimen in the management of the human immunodeficiency virus for both adults and children. It is efficacious, but its use may
Mathew K. Koech, Shamim M. Ali, Mercy J. Karoney, Gabriel Kigen   +3 more
doaj   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, Volume 13, Issue 10, Page 2138-2142, October 2026.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Lamivudine/abacavir maintains virological superiority over zidovudine/lamivudine and zidovudine/abacavir beyond 5 years in children.

, 2016
OBJECTIVE: To describe the long-term efficacy over 5 years of regimens including combinations of abacavir, lamivudine and/or zidovudine in previously untreated children in the PENTA 5 trial.

core   +1 more source

Consequences of drug binding to immune receptors: Immune stimulation following pharmacological interaction with immune receptors (T-cell receptor for antigen or human leukocyte antigen) with altered peptide-human leukocyte antigen or peptide

Dermatologica Sinica, 2013
Drugs may stimulate the immune system by forming hapten–carrier complexes or via their pharmacological features, namely by noncovalent binding to proteins such as immune receptors.
Werner J. Pichler
doaj   +1 more source

Paediatric antiretroviral overdose: A case report from a resource-poor area

Southern African Journal of HIV Medicine, 2020
Introduction: Toxic side effects from antiretroviral overdose in children have not been widely reported. Antiretroviral drugs are widely used as oral medications throughout sub-Saharan Africa.
Bryan A. Ogoti, Angela A. Otedo, Thomas M. Chokwe   +2 more
doaj   +1 more source