Results 41 to 50 of about 26,674 (238)

Editorial: choosing new targets for rheumatoid arthritis therapeutics: too interesting to fail? [PDF]

, 2017
No abstract ...
McInnes, Iain B., Porter, Duncan, Siebert, Stefan   +2 more
core   +1 more source

Re-administration of abatacept for the control of articular symptoms of rheumatoid arthritis during anti-tuberculous therapy

Respiratory Medicine Case Reports, 2017
This case report describes the re-administration of abatacept to successfully reduce the articularsymptoms of a patient with rheumatoid arthritisduring the intensive phase of anti-tuberculous therapy.
Hironori Kawamoto, M.D., Jin Takasaki, Satoru Ishii, Manabu Suzuki, Eriko Morino, Go Naka, Motoyasu Iikura, Shinyu Izumi, Yuichiro Takeda, Haruhito Sugiyama   +9 more
doaj   +1 more source

Abatacept enhances blood regulatory B cells of rheumatoid arthritis patients to a level that associates with disease remittance

Scientific Reports, 2021
Abatacept, an inhibitor of CD28 mediated T-cell activation, has been shown to be effective in controlling inflammation during rheumatoid arthritis (RA). However, its effects on immune regulatory B and T cells (Bregs and Tregs) has not been fully explored.
Maha Fahad Alenazy, Fatemeh Saheb Sharif-Askari, Mohammed A. Omair, Mohammad S. El-Wetidy, Maha A. Omair, Hussam Mitwalli, Saleh Al-Muhsen, Abeer Al-Masri, Qutayba Hamid, Rabih Halwani   +9 more
doaj   +1 more source

Persistencia de medicamentos biológicos durante ocho años en pacientes con artritis reumatoide y espondiloartritis [PDF]

, 2019
Objective: To calculate the persistence, over a period of eight years, the retention rate of first and second-line of treatment with biological agents in patients with rheumatoid arthritis, spondyloarthritis and psoriatic arthritis and to compare ...
Balsa, Alejandro, González-Fernández, María, Herrero, Alicia, Jiménez-Nácher, Inmaculada, Moreno, Francisco, Villamañán, Elena   +5 more
core   +3 more sources

PTCy, abatacept, and a short course of tacrolimus for GVHD prevention after haploidentical transplantation

Blood Advances, 2023
Key Points • CAST regimen is safe and effective in reducing acute GVHD after haploidentical peripheral blood transplantation.• Our outcomes provide an impetus to further examine this novel combination in GVHD prevention.
A. Al-Homsi, Frank Cirrone, S. Wo, Kelli A. Cole, J. A. Suarez-Londono, S. Gardner, J. Hsu, Kelsey Stocker, B. Bruno, J. Goldberg, B. Levinson, M. Abdul-Hay   +11 more
semanticscholar   +1 more source

Abatacept used in combination with non-methotrexate disease-modifying antirheumatic drugs: a descriptive analysis of data from interventional trials and the real-world setting

Arthritis Research & Therapy, 2018
Background Methotrexate (MTX) remains the anchor drug in rheumatoid arthritis (RA) treatment, but is poorly tolerated or contraindicated in some patients.
Rieke Alten, Harald Burkhardt, Eugen Feist, Klaus Krüger, Juergen Rech, Andrea Rubbert-Roth, Reinhard E. Voll, Yedid Elbez, Christiane Rauch   +8 more
doaj   +1 more source

Prognostic factors for abatacept retention in patients who received at least one prior biologic agent: an interim analysis from the observational, prospective ACTION study [PDF]

, 2015
Background: The emergence of new therapies for the treatment of rheumatoid arthritis (RA), the paucity of head-to-head studies, and the heterogeneous nature of responses to current biologics highlight the need for the identification of prognostic factors
Alten, Rieke, Bensen, William G., Burmester, Gerd R., Chartier, Melanie, Galeazzi, Mauro, Le Bars, Manuela, Lorenz, Hanns-Martin, Nurmohamed, Michael T., Nüßlein, Hubert G., Pavelka, Karel, Peter, Hans-Hartmut, Poncet, Coralie, Rauch, Christiane   +12 more
core   +2 more sources

Abatacept and non-melanoma skin cancer in patients with rheumatoid arthritis: a comprehensive evaluation of randomised controlled trials and observational studies

Annals of the Rheumatic Diseases, 2023
Objectives This study aims to evaluate non-melanoma skin cancer (NMSC) risk associated with abatacept treatment for rheumatoid arthritis (RA). Methods This evaluation included 16 abatacept RA clinical trials and 6 observational studies.
Teresa A. Simon, Lixian Dong, Samy Suissa, Kaleb Michaud, S. Pedro, M. Hochberg, Maarten Boers, J. Askling, T. Frisell, Anja Strangfeld, Y. Meissner, V. Khaychuk, A. Dominique, Michael A Maldonado   +13 more
semanticscholar   +1 more source

Immunopathogenesis of rheumatoid arthritis [PDF]

, 2017
Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an immune-mediated etiology associated with stromal tissue dysregulation that
Ahmed, Ai, Ai, Anzilotti, Arend, Astorri, Benham, Bombardieri, Bottini, Bottini, Byng-Maddick, Catrina, Catrina, Charles-Schoeman, Christophorou, Corsiero, Croft, de Aquino, de Hair, Deane, Dennis, Diarra, Ekwall, El-Gabalawy, Ferreira, Filer, Firestein, Firestein, Firestein, Firestein, Firestein, Fonseca, Franz, Gary S. Firestein, Genovese, Hammaker, Harre, Hill, Horiuchi, Huber, Iain B. McInnes, Joosten, Juarez, Kaminsky, Karouzakis, Kelly, Kiener, Kim, Kinslow, Kirschmann, Klarenbeek, Konig, Konig, Krishnadas, Krishnamurthy, Källberg, Langley, Law, Lee, Lefèvre, Linn-Rasker, Liu, Lubberts, Lundström, Makrygiannakis, Matsumoto, McInnes, McInnes, McInnes, McInnes, McKellar, Miossec, Mydel, Müller-Ladner, Nakamachi, Nakano, Nakano, Nam, Okada, Pap, Perlman, Pitzalis, Randen, Rawlings, Raychaudhuri, Raza, Reynisdottir, Reynisdottir, Robertson, Rodríguez-Carrio, Rombouts, Rossetti, Scally, Scher, Schiff, Shi, Shi, Smolen, Smolen, Snir, Sokolove, Stanczyk, Suzuki, Tan, Tran, Tsaprouni, van Beers, van der Helm-van Mil, Vassallo, Wang, Wegner, Weyand, Yamamoto, Yang, Zhang, Zvaifler   +115 more
core   +1 more source

Role of abatacept in the prevention of graft-versus-host disease: current perspectives

Therapeutic Advances in Hematology, 2023
Administration of abatacept following transplantation has been reported to inhibit graft rejection and graft-versus-host-disease (GvHD) in mouse models associated with allogeneic hematopoietic stem cell transplant (HSCT).
Alexander Ngwube, H. Rangarajan, N. Shah
semanticscholar   +1 more source