Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia +10 more
wiley +1 more source
Molecular mechanisms of peanut root responses to Cd stress regulated by ABC transporter and plant hormone signal transduction pathways. [PDF]
Feng D +8 more
europepmc +1 more source
Insights into the recognition of cyclic α-(1→6)-glucan by a solute-binding protein of an ABC transporter from Tepidibacillus decaturensis. [PDF]
Takei S, Saburi W, Yao M, Mori H, Ose T.
europepmc +1 more source
Structural analysis of a Gram-positive type VII ABC transporter induced by cell wall-targeting antibiotics. [PDF]
Yu P +4 more
europepmc +1 more source
ABSTRACT The global trend toward sustainable and intensified bioprocesses is driving innovation in the design and scalable synthesis of liposomal nanocarriers, a cornerstone of modern drug delivery. For decades, these nanosystems have relied exclusively on polyethylene glycol (PEG) for their sustained circulation in vivo, but they are currently ...
Chandra Has
wiley +1 more source
The ATP Binding Cassette (ABC) Transporter Gene Family in Lotus (<i>Nelumbo</i> Adans.): Genome-Wide Survey, Characterization and Gene Expression Profile. [PDF]
Zhao Y +6 more
europepmc +1 more source
Abstract Basking sharks, Cetorhinus maximus (Gunnerus, Brugden [Squalus maximus], Det Kongelige Norske Videnskabers Selskabs Skrifter, 1765, vol. 3, pp. 33–49), feed by gaping their mouths and gill slits, greatly reorienting their cranial skeletons to filter food from water.
Tairan Li +12 more
wiley +1 more source
Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter. [PDF]
Carrillo VHP +8 more
europepmc +1 more source

