British Journal of Clinical Pharmacology, EarlyView.Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti +9 more
wiley +1 more source
Integrated transcriptomic and metabolomic analyses reveal the ABC transporter-related genes and metabolites involved in seed aging of Platostoma palustre (Blume) A. J. Paton. [PDF]
BMC Plant BiolTang D, Li J, Quan C, Xu M, Wei F.
europepmc +1 more source
Genetically Programmed Control of Overflow Metabolism
Biotechnology and Bioengineering, EarlyView.ABSTRACT Overflow metabolism is a highly undesirable phenomenon that occurs in virtually all cell factories. Although several schemes have been applied to avoid overflow metabolism, this problem remains far from being solved. In this study, a genetic sensor for detecting overflow metabolism was designed, and its substrate specificity and reversibility ...
Lærke M. Jensen +3 more
wiley +1 more source
Synergistic modulation of ABC transporter-mediated multidrug resistance by <i>Kalanchoe laciniata</i> (L.) DC. phytochemicals: integrative phytochemical profiling, network pharmacology, and molecular docking insights. [PDF]
RSC AdvS AR +3 more
europepmc +1 more source
BMEMat, EarlyView.Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu +13 more
wiley +1 more source
Structural characterization of the YbbAP-TesA ABC transporter identifies it as a lipid hydrolase complex that extracts hydrophobic compounds from the bacterial inner membrane. [PDF]
PLoS BiolMcAndrew MBL +6 more
europepmc +1 more source
The influence of rivers on seabird foraging ecology
Biological Reviews, EarlyView.ABSTRACT Rivers act as vital arteries to the world's oceans, delivering fresh water and nutrients that sustain marine ecosystems. Globally, river flow increasingly is being altered by climate change and anthropogenic pressures; yet the significance of rivers to predatory marine species, such as seabirds, and the extent to which river‐related changes ...
Julia B. Morais +2 more
wiley +1 more source
Glycosomal ABC transporter 3 (GAT3) deletion enhances the oxidative stress responses and reduces the infectivity of Trypanosoma cruzi. [PDF]
PLoS Negl Trop DisLima DA +8 more
europepmc +1 more source
The Degradation of Access‐Based Business Models: Customer Misbehavior and Shared Mobility
Business Strategy and the Environment, EarlyView.ABSTRACT Access‐based services are considered one of the strategies to embed sustainability in business models. Yet, because the evolution of these business models has been overlooked, we do not know whether their promise to create triple value is sustained.
Andres Camacho, Carmen Valor
wiley +1 more source
ABC transporter activity is affected by the size of lipid nanodiscs. [PDF]
FEBS LettNouel Barreto A, Cuello LG, Zoghbi ME.
europepmc +1 more source