Results 211 to 220 of about 74,030 (255)

ABC transporters of staphylococci

Research in Microbiology, 2001
Some members of the genus Staphylococcus are important human pathogens, such as Staphylococcus aureus and Staphylococcus epidermidis. ATP binding cassette (ABC) transporters of pathogenic staphylococci are often responsible for antibiotic resistance and for the uptake of essential solutes and are therefore being considered as targets for novel ...
M, Otto, F, Götz
openaire   +2 more sources

Mitochondrial ABC transporters

Research in Microbiology, 2001
In contrast to bacteria, mitochondria contain only a few ATP binding cassette (ABC) transporters in their inner membrane. The known mitochondrial ABC proteins fall into two major classes that, in the yeast Saccharomyces cerevisiae, are represented by the half-transporter Atm1p and the two closely homologous proteins Mdl1p and Mdl2p. In humans two Atm1p
R, Lill, G, Kispal
openaire   +2 more sources

Leukemia and ABC Transporters

2015
Acute myeloid leukemia (AML) is a heterogeneous disease caused by aberrant proliferation and/or differentiation of myeloid progenitors. However, only ~65% of AML patients respond to induction chemotherapy and the overall survival rate for AML remains low (~24% for 5-year survival).
Yu, Fukuda, Shangli, Lian, John D, Schuetz   +2 more
openaire   +2 more sources

ABC Transporters and Neuroblastoma

2015
Neuroblastoma is the most common cancer of infancy and accounts for 15% of all pediatric oncology deaths. Survival rates of high-risk neuroblastoma remain less than 50%, with amplification of the MYCN oncogene the most important aberration associated with poor outcome. Direct transcriptional targets of MYCN include a number of ATP-binding cassette (ABC)
Denise M T, Yu, Tony, Huynh, Alan M, Truong, Michelle, Haber, Murray D, Norris   +4 more
openaire   +2 more sources

Structure of ABC transporters

Essays in Biochemistry, 2011
ABC (ATP-binding cassette) transporters are primary active membrane proteins that translocate solutes (allocrites) across lipid bilayers. The prototypical ABC transporter consists of four domains: two cytoplasmic NBDs (nucleotide-binding domains) and two TMDs (transmembrane domains).
Joseph K, Zolnerciks, Edward J, Andress, Michael, Nicolaou, Kenneth J, Linton   +3 more
openaire   +2 more sources

Insights into ABC Transport in Archaea

Journal of Bioenergetics and Biomembranes, 2004
In archaea, ATP-binding cassette (ABC) transporters play a crucial role in substrate uptake, export, and osmoregulation. Archael substrate-binding-protein-dependent ABC transporters are equipped with a very high affinity for their cognate substrates which provide these organisms with the ability to efficiently scavenge substrates from their environment
Albers, Sonja Verena, Koning, Sonja M., Konings, Wil N., Driessen, Arnold J. M.   +3 more
openaire   +4 more sources

ABC Family Transporters

2019
The transport of specific molecules across lipid membranes is an essential function of all living organisms. The processes are usually mediated by specific transporters. One of the largest transporter families is the ATP-binding cassette (ABC) family.
openaire   +2 more sources

ABC Transporters in the CNS – An Inventory

Current Pharmaceutical Biotechnology, 2011
In the present review we provide a summary of ATP-binding cassette (ABC) transporters in the central nervous system (CNS). Our review is focused on transporters of the ABC A, B, C, D, and G families that have been detected in the cells of the neurovascular unit/blood-brain barrier including brain capillary endothelial cells, pericytes, astrocytes, and ...
A M S, Hartz, B, Bauer
openaire   +2 more sources

LIPID TRANSPORT BY ABC TRANSPORTERS

2003
Borst, P., van Meer, G. F. B. P., Oude Elferink, R. P. J.   +2 more
openaire   +3 more sources

A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance

Molecules, 2023
Gerhard Ecker, Ecker Gerhard F
exaly