Results 181 to 190 of about 81,965 (299)

Terpenoids: Emerging Natural Modulators for Reversing ABC Transporter-Mediated Multidrug Resistance in Cancer Chemotherapy. [PDF]

Pharmaceuticals (Basel)
Ma L, Mahemuti D, Lan Y, Xu J, Li W, Su Z, Li J, Abuduwaili A, Maimaitijiang A.   +8 more
europepmc   +1 more source

Spotlight on the Nucleotide: Solid‐State NMR for the Investigation of ATP Hydrolysis in the ATPase SmsC

Chemistry – A European Journal, EarlyView.
Nucleotide‐detected solid‐state NMR has been applied to probe nucleotide conformations and dynamics during ATP hydrolysis using the dimeric P‐loop ATPase SmsC as a model protein. The different stages of ATP hydrolysis have been mimicked by ATP analogues for which different degrees of conformational heterogeneity have been observed. ABSTRACT Solid‐state
Nina Wehr, Laure Decamps, Julius Schlüter, Koen Linssen, Georg Künze, Kushal Sengupta, Serena DeBeer, Thomas Wiegand   +7 more
wiley   +1 more source

ABC Transporter [PDF]

, 2020
openaire   +1 more source

Molecular mechanisms of peanut root responses to Cd stress regulated by ABC transporter and plant hormone signal transduction pathways. [PDF]

BMC Plant Biol
Feng D, Lin D, Liang Z, Chen T, Feng E, Lin Q, Hu H, Xue Y, Liu Y.   +8 more
europepmc   +1 more source

Post‐Modification of Tripyrenylenes to Enantiopure π‐Extended D3‐Symmetric Propellers

Chemistry – A European Journal, EarlyView.
The post‐modification of tripyrenylenes to π‐extended enantiopure propellers with tris‐phenanthrophenazines is presented and the chiroptical properties as well as the solid‐state packings investigated in comparison to the corresponding racemic mixtures.
Dennis Popp, Melanie Bruttel, Sebastian Möbert, Anusha Sounder Rajan, Christoph Keck, Darius Boehm, Frank Rominger, Sven M. Elbert, Michael Mastalerz   +8 more
wiley   +1 more source

ABC Transporters and Drug Transport [PDF]

Journal of Korean Society for Clinical Pharmacology and Therapeutics, 2003
Ji Ha Choi, Min Goo Lee
openaire   +1 more source

Insights into the recognition of cyclic α-(1→6)-glucan by a solute-binding protein of an ABC transporter from Tepidibacillus decaturensis. [PDF]

J Biol Chem
Takei S, Saburi W, Yao M, Mori H, Ose T.
europepmc   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Structural analysis of a Gram-positive type VII ABC transporter induced by cell wall-targeting antibiotics. [PDF]

Structure
Yu P, Krah BS, Orlando MA, Subramanian S, Orlando BJ.   +4 more
europepmc   +1 more source

Resolving CYP2D6 Structural Complexity with Long‐Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Cytochrome P450 2D6 (CYP2D6)‐mediated bioactivation of tamoxifen to endoxifen is a key determinant of therapeutic efficacy in estrogen receptor‐positive breast cancer. In Asian populations, the high prevalence of structurally complex CYP2D6 alleles complicates conventional genotyping, limiting accurate genotype–phenotype correlation.
Usa Boonyuen, Sirinyatorn Talukam, Beatriz Aira C. Jacob, Wayu Matphong, Kamonwan Chamchoy, Onrapak Reamtong, Nuntana Meesiripan, Junya Yamagishi, Matthew Phanchana, Chayanoot Rattadilok   +9 more
wiley   +1 more source