Results 71 to 80 of about 110,036 (294)

Simultaneous prediction of four ATP-binding cassette transporters' substrates using multi-label QSAR [PDF]

, 2016
Efflux by the ATP-binding cassette (ABC) transporters affects the pharmacokinetic profile of drugs and it has been implicated in drug-drug interactions as well as its major role in multi-drug resistance in cancer.
Bentz, Bolón-Canedo, Broccatelli, Demel, Desai, Dragos, Eriksson, Ganta, Gibaja, Gupta, Iyer, Krein, Legrand, Lu-Emerson, Luaces, Maaten, Maggiora, Mak, Marquez, Matsson, Mittal, Montanari, Newby, Oberoi, Pinto, Read, Saeys, Sechidis, Sedykh, Shahlaei, Spolaôr, Stumpfe, Sushko, Sushko, Szakács, Tetko, Tetko, Tsaioun, Tsoumakas, Tsoumakas, Vastag, Wassermann, Wind, Zhang   +43 more
core   +1 more source

Bioengineered Lymphatic Vessels in Synthetic Matrices to Study Breast Cancer Cell Functions

Advanced Healthcare Materials, EarlyView.
Lymphatic vessels are involved in cancer metastasis. To study the interplay between metastasizing cancer cells and lymphatic vessels under highly reproducible conditions, advanced in vitro models are required. In this work, 3D lymphatic networks are formed in biomimetic hydrogels and their interactions with invasive and non‐invasive cancer cell‐lines ...
Rodi Odabasi, Lisa A. Krattiger, Magdalini Kanari, Mira A. Jacobs, Lukas O. Moser, Mark W. Tibbitt, Cornelia Halin, Martin Ehrbar   +7 more
wiley   +1 more source

Human ATP-binding cassette (ABC) transporter family

Human Genomics, 2009
There exist four fundamentally different classes of membrane-bound transport proteins: ion channels; transporters; aquaporins; and ATP-powered pumps. ATP-binding cassette (ABC) transporters are an example of ATP-dependent pumps.
Vasiliou Vasilis, Vasiliou Konstandinos, Nebert Daniel W   +2 more
doaj   +1 more source

Fructooligosaccharide Utilization by Streptococcus pneumoniae [PDF]

, 2012
Arts and Sciences Undergraduate Research ScholarshipASM Undergraduate FellowshipStreptococcus pneumoniae (pneumococcus), a leading cause of morbidity and mortality worldwide, commonly colonizes the oronasopharynx asymptomatically but can on occasion ...
Linke, Caroline
core  

The E. coli BtuCD Structure: A Framework for ABC Transporter Architecture and Mechanism [PDF]

, 2002
The ABC transporters are ubiquitous membrane proteins that couple adenosine triphosphate (ATP) hydrolysis to the translocation of diverse substrates across cell membranes.
Lee, Allen T., Locher, Kaspar P., Rees, Douglas C.   +2 more
core   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

ABC transporters are involved in defense against permethrin insecticide in the malaria vector Anopheles stephensi

Parasites & Vectors, 2014
Background Proteins from the ABC family (ATP-binding cassette) represent the largest known group of efflux pumps, responsible for transporting specific molecules across lipid membranes in both prokaryotic and eukaryotic organisms. In arthropods they have
Sara Epis, Daniele Porretta, Valentina Mastrantonio, Francesco Comandatore, Davide Sassera, Paolo Rossi, Claudia Cafarchia, Domenico Otranto, Guido Favia, Claudio Genchi, Claudio Bandi, Sandra Urbanelli   +11 more
doaj   +1 more source

Tripartite ATP-Independent Periplasmic (TRAP) Transporters and Tripartite Tricarboxylate Transporters (TTT): From Uptake to Pathogenicity [PDF]

, 2018
The ability to efficiently scavenge nutrients in the host is essential for the viability of any pathogen. All catabolic pathways must begin with the transport of substrate from the environment through the cytoplasmic membrane, a role executed by membrane
Bianconi, M.E., Kelly, D.J., Rosa, L.T., Thomas, G.H.   +3 more
core   +3 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Genome-Wide Transposon Screen of a Pseudomonas syringae mexB Mutant Reveals the Substrates of Efflux Transporters. [PDF]

, 2019
Bacteria express numerous efflux transporters that confer resistance to diverse toxicants present in their environment. Due to a high level of functional redundancy of these transporters, it is difficult to identify those that are of most importance in ...
Deutschbauer, Adam M, Helmann, Tyler C, Lam, Jennifer, Lindow, Steven E, Ongsarte, Caitlin L   +4 more
core   +1 more source