Results 91 to 100 of about 6,676 (188)
Aging Cell, Volume 24, Issue 11, November 2025.DP1 receptor blockade attenuates microglial senescence and cognitive decline caused by PTGDS in exosomes from aged brains. ABSTRACT Aging leads to neurodegenerative diseases, such as cognitive decline, which are induced by persistent chronic low‐grade inflammation in the brain driven by microglial activation.
Yaru Liu +12 more
wiley +1 more source
Pharmacogenetic: screening relevant polymorphisms on antiretroviral therapy in a HIV Portuguese population [PDF]
, 2015 Poster presented at the 15th European AIDS Conference. Barcelona, 21-24 October 2015"Several factors cause heterogeneity of response to antiretroviral therapy.
Cruz, J. P. +5 more
core
Diversity and evolution of ABC proteins in mycorrhiza-forming fungi [PDF]
, 2015 Background: Transporter proteins are predicted to have an important role in the mycorrhizal symbiosis, due to the fact that this type of an interaction between plants and fungi requires a continuous nutrient and signalling exchange.
Asiegbu, Fred O. +3 more
core +3 more sources
Epilepsia, Volume 66, Issue 10, Page 3769-3784, October 2025.Abstract Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which converts 3‐phosphoglycerate to generate serine and the neurotransmitter glycine, with (drug‐resistant ...
Karin Thevissen +25 more
wiley +1 more source
Bacillus anthracis edema factor substrate specificity: evidence for new modes of action [PDF]
, 2012 Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Agrawal +94 more
core +2 more sources
Stabilization of Human Multidrug Resistance Protein 4 (MRP4/ABCC4) Using Novel Solubilization Agents [PDF]
SLAS Discovery, 2019 Membrane proteins (MPs) are important drug discovery targets for a wide range of diseases. However, elucidating the structure and function of native MP is notoriously challenging as their original structure has to be maintained once removed from the lipid bilayer.
David Hardy +3 more
openaire +3 more sources
Cancer Medicine, Volume 14, Issue 18, September 2025.ABSTRACT Colorectal cancer (CRC) is a major cause of cancer‐related mortality, especially in the Western world, and its incidence is expected to increase in the years to come. Prevention and early detection are key strategies to improve CRC morbidity and mortality.
Ulrike Ries Feddersen +5 more
wiley +1 more source
Prostaglandin pathway gene expression in human placenta, amnion and choriodecidua is differentially affected by preterm and term labour and by uterine inflammation [PDF]
, 2014 BACKGROUND: Elucidation of the biochemical pathways involved in activation of preterm and term human labour would facilitate the development of effective management and inform judgements regarding the necessity for preterm tocolysis and post-term ...
Andrés López Bernal +2 more
core +1 more source
Perinatal Maturation of Drug Transporters and Claudin‐5 at the Blood–Brain Barrier
CNS Neuroscience &Therapeutics, Volume 31, Issue 9, September 2025.P‐gp expression in the developping human cortex increases with age. In the mouse, gatekeepers of BBB integrity and transport are upregulated: tighter blood–brain barrier, increased claudin 5/Slco1a4/P‐gp expression as well as enhanced P‐gp‐mediated BBB efflux.
Laetitia Federici +9 more
wiley +1 more source
Monitoring storage induced changes in the platelet proteome employing label free quantitative mass spectrometry [PDF]
, 2017 Shelf life of platelet concentrates is limited to 5-7 days due to loss of platelet function during storage, commonly referred to as the platelet storage lesion (PSL).
Alphen, F.P. (Floris) van +8 more
core +1 more source