Results 71 to 80 of about 3,675 (154)
CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.This study integrated multi‐omics data to analyze the synergistic effects of cellular senescence and RNA modifications on AD pathology. Transcriptome and proteome data were used to validate the stability of machine learning‐screened proteins and the model, while metabolomics data further revealed metabolic alterations during the progression of AD ...
Mengjie Tian +9 more
wiley +1 more source
Zhongguo aizheng zazhi, 2014 Background and purpose: Natural killer/T cell lymphoma in poor effects, the production of multidrug resistance is one of the reasons to reduce the chemotherapy effect or failure.
李汝平 +6 more
doaj
Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack +39 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.E. faecalis is enriched in HCC tissue and can promote liver tumourigenesis by activating mTOR signalling pathway. Obg derived from E. faecalis extracellular vesicles (EVs) is a GTPase physically interacts with mTOR, and acts as an interkingdom activator of mTOR. EF‐Obg expression level in HCC tissue correlates with poor prognosis in HCC patients.
Ning Ma +18 more
wiley +1 more source
NAD+‒circadian rhythm coupling in dementia
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang +7 more
wiley +1 more source
Liver International, Volume 46, Issue 5, May 2026.ABSTRACT Background and Aims Loss‐of‐function mutations in bile acid (BA)‐activated farnesoid x receptor (FXR/NR1H4) cause severe neonatal liver pathology in humans, earlier referred to as progressive familial intrahepatic cholestasis type 5 (PFIC5). However, Fxr‐deficient mice do not develop early‐onset liver disease, possibly due to the predominance ...
Hilde D. de Vries +16 more
wiley +1 more source
The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.Abstract Cytochrome P450 3A4 (CYP3A4) is an important drug‐metabolizing enzyme, whose function is impacted by age, sex, body weight, pregnancy, and disease. It is also the site of major drug interactions involving inhibition and induction. Because CYP3A4 is expressed in the intestine and liver, investigators have sought to study its function in both ...
David Rodrigues
wiley +1 more source
PLoS ONE, 2016 BackgroundIn Thailand, the combined generic anti-retroviral drug stavudine/lamivudine/nevirapine (d4T/3TC/NVP) has been used to treat human immunodeficiency virus (HIV)-infected individuals since 2001.
Sirirat Likanonsakul +6 more
doaj +1 more source
Genetic Ablation of the ABC Transporter Abcc4 Impairs Lymphoid Leukemogenesis
The FASEB Journal, 2018 ABCC4 is an ABC transporter of the C sub‐family that is ubiquitously expressed and exports key endogenous compounds including cAMP and prostaglandins, and cancer chemotherapeutic drugs. cAMP and prostaglandins are signaling molecules that, among other functions, regulate thymocyte development and function.
Rebecca R. Crawford +5 more
openaire +1 more source
PLoS ONE, 2013 Overexpression of multidrug transporters is a well-established mechanism of resistance to chemotherapy, but other changes may be co-selected upon exposure to drugs that contribute to resistance.
Nancy E Caceres +6 more
doaj +1 more source