Results 61 to 70 of about 3,675 (154)

The cytokinin efflux transporter ABCC4 participates in Arabidopsis root system development. [PDF]

Plant Physiol
Abstract The directional and sequential flow of cytokinin in plants is organized by a complex network of transporters. Genes involved in several aspects of cytokinin transport have been characterized; however, much of the elaborate system remains elusive.
Uragami T, Kiba T, Kojima M, Takebayashi Y, Tozawa Y, Hayashi Y, Kinoshita T, Sakakibara H.   +7 more
europepmc   +3 more sources

Temperature dependence of HCN channel kinetics: A systematic comparison across mammalian isoforms and species

Experimental Physiology, Volume 111, Issue 10, Page 4659-4687, 1 October 2026.
Abstract Hyperpolarization‐activated, cyclic nucleotide‐gated (HCN) channels are important regulators of cardiac pacemaking and neuronal excitability, yet their temperature dependence has not been compared systematically across mammalian isoforms and species in standardized experimental conditions. Here, we performed a standardized electrophysiological
Rajnish Ranjan, Emmanuelle Logette, Mirjia Herzog, Valerie Buchillier, Enrico Scantamburlo, Henry Markram   +5 more
wiley   +1 more source

Gene expression profile of ABC transporters and cytotoxic effect of ibuprofen and acetaminophen in an epithelial ovarian cancer cell line in vitro [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2015
PURPOSES: To determine the basic expression of ABC transporters in an epithelial ovarian cancer cell line, and to investigate whether low concentrations of acetaminophen and ibuprofen inhibited the growth of this cell line in vitro.
Renilton Aires Lima, Eduardo Batista Cândido, Flávia Perrim de Melo, Josiane Barbosa Piedade, Paula Vieira Teixeira Vidigal, Luciana Maria Silva, Agnaldo Lopes da Silva Filho   +6 more
doaj   +1 more source

Alignment of Micrometer‐Scale Electrospun Fibers Does Not Enhance Performance of Primary Human Renal Proximal Tubular Epithelial Cells

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 9, September 2026.
ABSTRACT Renal failure remains a leading cause of morbidity and mortality, as current renal replacement therapies restore filtration but fail to replicate the kidney's transport, metabolic, and endocrine functions. Bioengineered systems using primary renal epithelial cells show promise in recapitulating these processes, and integration into synthetic ...
IJsbrand M. Vermue, Christian G. M. van Dijk, Ihsan Chrifi, Ymke Appels, Jurjen van Meijeren, Bastiaan Terhaard, Nahid Kasaiyan, Marianne C. Verhaar, Caroline Cheng   +8 more
wiley   +1 more source

A Role for ABCC4 in Regulating Pigment Granule Aggregation in Mice

The FASEB Journal, 2019
ABCC4 is member of the family of ATP‐binding cassette proteins that specialize in transporting a variety of molecules out of the cell. ABCC4 exports signaling molecules present in the retina, including cyclic adenosine monophosphate (cyclic AMP).
Thomas Mireles, Dora Evelyn Ibarra, Emely Reimer Wiebe, Amanda M Pattillo, Cody J Rodriguez, John D Schuetz, Dana M García   +6 more
openaire   +1 more source

An Optimized Diagnostic Approach for Adults With Suspected Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
A multidisciplinary strategy that integrates deep phenotyping with expert genetic interpretation substantially increases the likelihood of reaching a diagnosis in adults suspected of having an IMD. ABSTRACT Inherited metabolic disorders (IMDs) arise from defects in metabolic pathways essential for normal biochemical function.
Machteld M. Oud, Elise A. Ferreira, Clara D. M. van Karnebeek, Robin Wijngaard, Nicole I. Wolf, Marc Engelen, Mareen Datema, Sacha Ferdinandusse, André B. P. van Kuilenburg, Laura Steinbusch, Saskia N. van der Crabben, Mirjam Langeveld, on behalf of the ZOEMBA Study Group   +12 more
wiley   +1 more source

Differential Expression of ABC Transporter Genes in Brain Vessels vs. Peripheral Tissues and Vessels from Human, Mouse and Rat

Pharmaceutics, 2023
Background: ATP-binding cassette (ABC) transporters comprise a superfamily of genes encoding membrane proteins with nucleotide-binding domains (NBD).
Wandong Zhang, Qing Yan Liu, Arsalan S. Haqqani, Ziying Liu, Caroline Sodja, Sonia Leclerc, Ewa Baumann, Christie E. Delaney, Eric Brunette, Danica B. Stanimirovic   +9 more
doaj   +1 more source

Uterine Dysfunctions in Non‐Pregnant and Pregnant Small Animals

Reproduction in Domestic Animals, Volume 61, Issue S2, September 2026.
ABSTRACT Various uterine dysfunctions in non‐pregnant and pregnant dogs and cats exist and can have a significant impact on the animal's health and welfare, as well as the offspring in case of pregnant and postpartum animals. This article aims to provide an overview, focusing on pyometra, endometritis, and uterine inertia, mainly in dogs.
Sandra Goericke‐Pesch
wiley   +1 more source

A polymorphism in ABCC4 is related to efficacy of 5-FU/capecitabine-based chemotherapy in colorectal cancer patients

Scientific Reports, 2017
To investigate the association of microRNA (miRNA) binding-site polymorphisms in the drug transporter genes with the efficacy of 5-Fluorouracil (5-FU)/capecitabine-based chemotherapy in colorectal cancer (CRC), 6 polymorphisms were determined in 432 CRC ...
Qi Chen, Fanyi Meng, Lei Wang, Yong Mao, Huan Zhou, Dong Hua, Hongjian Zhang, Weipeng Wang   +7 more
doaj   +1 more source

Genome-wide association study identifies candidate loci associated with chronic pain and postherpetic neuralgia

Molecular Pain, 2021
Background Human twin studies and other studies have indicated that chronic pain has heritability that ranges from 30% to 70%. We aimed to identify potential genetic variants that contribute to the susceptibility to chronic pain and efficacy of ...
Daisuke Nishizawa, Masako Iseki, Hideko Arita, Kazuo Hanaoka, Choku Yajima, Jitsu Kato, Setsuro Ogawa, Ayako Hiranuma, Shinya Kasai, Junko Hasegawa, Masakazu Hayashida, Kazutaka Ikeda   +11 more
doaj   +1 more source