Results 41 to 50 of about 4,110 (154)
BMC Infectious Diseases, 2017 Background Tenofovir (TDF) is one of the most widely used antiretroviral drug. Despite the high degree of tolerability a small percentage of patients experienced alteration in tubular function during TDF use. Intracellular TDF disposition is regulated by
S. E. Salvaggio +8 more
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The Journal of Physiology, EarlyView.Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass +2 more
wiley +1 more source
Figure 3: Enhanced ABCC4 Protein Expression in HIV
, 2019 (A) Immunoblots of ABCC4 in platelet lysates from controls (C) (n = 8) and HIV (n = 14) subjects. Thirty micrograms of protein were loaded, and GAPDH was used as a loading control. Quantification after normalization is reported.
Nicole Allen (6821924) +11 more
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Postherpetic Neuralgia: Mechanisms, Risk Factors, and Stratified Management—A Narrative Review
CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.The incidence of PHN is increasing, posing a substantial public health burden. Its pathogenesis involves VZV reactivation, peripheral and central sensitization, and genetic susceptibility, with key risk factors including older age, severe acute pain, extensive rash, immunocompromise, comorbidities, and delayed treatment.
Fei Tang, Fukun Zhao
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Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cells
Scientific Reports, 2021 Cystic fibrosis (CF) is a genetic disease characterized by CF transmembrane regulator (CFTR) dysfunction. With over 2000 CFTR variants identified, in addition to known patient to patient variability, there is a need for personalized treatment.
Jenny P. Nguyen +5 more
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Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack +39 more
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Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.E. faecalis is enriched in HCC tissue and can promote liver tumourigenesis by activating mTOR signalling pathway. Obg derived from E. faecalis extracellular vesicles (EVs) is a GTPase physically interacts with mTOR, and acts as an interkingdom activator of mTOR. EF‐Obg expression level in HCC tissue correlates with poor prognosis in HCC patients.
Ning Ma +18 more
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The ABCC4 gene is associated with pyometra in golden retriever dogs
Scientific Reports, 2021 Pyometra is one of the most common diseases in female dogs, presenting as purulent inflammation and bacterial infection of the uterus. On average 20% of intact female dogs are affected before 10 years of age, a proportion that varies greatly between ...
Maja Arendt +11 more
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NAD+‒circadian rhythm coupling in dementia
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang +7 more
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Zebrafish Abcc4 is involved in the excretion of DDT and lindane in developing embryos.
, 2014 (A and B) Contents of DTT or lindane in embryos expressing GFP, Abcc4 and Abcc4-G1188D at the indicated exposure time points. (C and D) Contents of MCB in embryos expressing GFP, Abcc4 and Abcc4-G1188D after exposed to DTT or lindane at indicated ...
Xing Lu (1438414) +5 more
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