Results 41 to 50 of about 3,675 (154)
Frontiers in Pharmacology, 2023 Dyslipidemia due to renal insufficiency is a common complication in patients with chronic kidney diseases (CKD), and a major risk factor for the development of cardiovascular events.
Zebin Jiang +13 more
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PLoS ONE, 2021 Stress urinary incontinence (SUI) is a common condition in women and associated with extra-cellular matrix (ECM) reconstruction, which is mainly regulated by fibroblasts. However, the underlying mechanism remains obscure.
Xiaoyan Sun +6 more
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Molecular Genetics & Genomic Medicine, 2021 Background Susceptibility to Chronic Myeloid Leukemia (CML) may be modulated by genetic variables. However, the majority of previous investigations have focused on genetically homogeneous populations, resulting in a lack of evidence on how genetic ...
Natasha Monte +9 more
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ABCC4/MRP4: a MYCN-regulated transporter and potential therapeutic target in neuroblastoma [PDF]
Frontiers in Oncology, 2012 Resistance to cytotoxic drugs is thought to be a major cause of treatment failure in childhood neuroblastoma, and members of the ATP-binding cassette (ABC) transporter superfamily may contribute to this phenomenon by active efflux of chemotherapeutic agents from cancer cells.
Huynh, Tony +3 more
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Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines [PDF]
International Journal of Molecular Sciences, 2020 ABCC1 and ABCC4 utilize energy from ATP hydrolysis to transport many different molecules, including drugs, out of the cell and, as such, have been implicated in causing drug resistance. However recently, because of their ability to transport signaling molecules and inflammatory mediators, it has been proposed that ABCC1 and ABCC4 may play a role in the
Floren G. Low +4 more
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MRP4 (ABCC4) as a potential pharmacologic target for cardiovascular disease
Pharmacological Research, 2016 This review focuses on multidrug resistance protein 4 (MRP4 or ABCC4) that has recently been shown to play a role in cAMP homeostasis, a key-pathway in vascular biology and in platelet functions. In vascular system, recent data provide evidence that inhibition of MRP4 prevents human coronary artery smooth muscle cell proliferation in vitro and in vivo,
Tiphaine, Belleville-Rolland +6 more
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Variants in TPMT, ITPA, ABCC4 and ABCB1 genes as predictors of 6-mercaptopurine induced toxicity in children with acute lymphoblastic leukemia [PDF]
Journal of Medical Biochemistry, 2018 Background: Acute lymphoblastic leukemia is the most common childhood malignancy. Optimal use of anti leukemic drugs has led to less toxicity and adverse reactions, and a higher survival rate. Thiopurine drugs, including 6-mercaptopurine, are mostly used
Milošević Goran +10 more
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Frontiers in PharmacologyThe xenobiotic transporter ABCC4/MRP4 is highly expressed in pancreatic ductal adenocarcinoma (PDAC) and correlates with a more aggressive phenotype and metastatic propensity.
S. N. Gancedo +23 more
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An unexpected protein interaction promotes drug resistance in leukemia
Nature Communications, 2017 ABCC4 is a chemotherapeutic drug exporter highly expressed in acute myeloid leukemia. Here, the authors demonstrate that MPP1 anchors ABCC4 to the outer cell membrane mediating drug resistance in leukemic cells and identify antimycin A as a chemical ...
Aaron Pitre +19 more
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Journal of Ginseng Research, 2019 Background: Ginsenoside compound K (CK) is a promising drug candidate for rheumatoid arthritis. This study examined the impact of polymorphisms in NR1I2, adenosine triphosphate–binding cassette (ABC) transporter genes on the pharmacokinetics of CK in ...
Luping Zhou +11 more
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