Results 21 to 30 of about 3,523 (156)

Clinical Significance and Potential Mechanisms of ATP Binding Cassette Subfamily C Genes in Hepatocellular Carcinoma

Frontiers in Genetics, 2022
The purpose of this investigation was to assess the diagnostic and prognostic significance of ATP binding cassette subfamily C (ABCC) genes in hepatocellular carcinoma (HCC).
Xin Zhou, Xin Zhou, Jia-mi Huang, Jia-mi Huang, Tian-man Li, Tian-man Li, Jun-qi Liu, Jun-qi Liu, Zhong-liu Wei, Zhong-liu Wei, Chen-lu Lan, Chen-lu Lan, Guang-zhi Zhu, Guang-zhi Zhu, Xi-wen Liao, Xi-wen Liao, Xin-ping Ye, Xin-ping Ye, Tao Peng, Tao Peng   +19 more
doaj   +1 more source

Functional Expression of Multidrug Resistance Protein 4 MRP4/ABCC4 [PDF]

SLAS Discovery, 2019
To study the function and structure of membrane proteins, high quantities of pure and stable protein are needed. One of the first hurdles in accomplishing this is expression of the membrane protein at high levels and in a functional state. Membrane proteins are naturally expressed at low levels, so finding a suitable host for overexpression is ...
David Hardy, Roslyn M. Bill, Anass Jawhari, Alice J. Rothnie   +3 more
openaire   +3 more sources

Differential Selectivity of Human and Mouse ABCC4/Abcc4 for Arsenic Metabolites. [PDF]

Drug Metab Dispos
Millions of people globally are exposed to the proven human carcinogen arsenic at unacceptable levels in drinking water. In contrast, arsenic is a poor rodent carcinogen, requiring >100-fold higher doses for tumor induction, which may be explained by toxicokinetic differences between humans and mice.
Whitlock BD, Ma Y, Conseil G, O'Brien AR, Banerjee M, Swanlund DP, Lin ZP, Wang Y, Le XC, Schuetz JD, Cole SPC, Leslie EM.   +11 more
europepmc   +3 more sources

The cytokinin efflux transporter ABCC4 participates in Arabidopsis root system development. [PDF]

Plant Physiol
Abstract The directional and sequential flow of cytokinin in plants is organized by a complex network of transporters. Genes involved in several aspects of cytokinin transport have been characterized; however, much of the elaborate system remains elusive.
Uragami T, Kiba T, Kojima M, Takebayashi Y, Tozawa Y, Hayashi Y, Kinoshita T, Sakakibara H.   +7 more
europepmc   +3 more sources

ABCC4 Is a Determinant of Cytarabine‐Induced Cytotoxicity and Myelosuppression [PDF]

Clinical and Translational Science, 2016
Resistance to cytarabine remains a major challenge in the treatment of acute myeloid leukemia (AML). Based on previous studies implicating ABCC4/MRP4 in the transport of nucleosides, we hypothesized that cytarabine is sensitive to ABCC4‐mediated efflux, thereby decreasing its cytotoxic response against AML blasts.
Drenberg, CD, Hu, S, Li, L, Buelow, DR, Orwick, SJ, Gibson, AA, Schuetz, JD, Sparreboom, A, Baker, SD   +8 more
openaire   +2 more sources

Founder genetic variants of ABCC4 and ABCC11 in the Japanese population are not associated with the development of subacute myelo‐optico‐neuropathy (SMON)

Molecular Genetics & Genomic Medicine, 2022
Background Subacute myelo‐optico‐neuropathy (SMON) is a severe neurological disorder associated with clioquinol administration, which frequently occurred in Japan during the 1950s and 1960s.
Hideki Matsumoto, Hideo Sasai, Norio Kawamoto, Masato Katsuyama, Makoto Minamiyama, Satoshi Kuru, Toshiyuki Fukao, Hidenori Ohnishi, SMON research group members   +8 more
doaj   +1 more source

Potentiation of long-acting β2-agonist and glucocorticoid responses in human airway epithelial cells by modulation of intracellular cAMP

Respiratory Research, 2021
Introduction Over 300 million people in the world live with asthma, resulting in 500,000 annual global deaths with future increases expected. It is estimated that around 50–80% of asthma exacerbations are due to viral infections. Currently, a combination
Yechan Kim, Vincent Hou, Ryan D. Huff, Jennifer A. Aguiar, Spencer Revill, Nicholas Tiessen, Quynh Cao, Matthew S. Miller, Mark D. Inman, Kjetil Ask, Andrew C. Doxey, Jeremy A. Hirota   +11 more
doaj   +1 more source

HOXA13, Negatively Regulated by miR-139-5p, Decreases the Sensitivity of Gastric Cancer to 5-Fluorouracil Possibly by Targeting ABCC4

Frontiers in Oncology, 2021
PurposeChemoresistance remains a major challenge in the therapy of gastric cancer (GC). The homeobox (HOX) gene family has gained attention in carcinogenesis and chemoresistance.
Zhengqian Chen, Zhengqian Chen, Zhiwei Qin, Lei Li, Qi Wo, Xia Chen   +5 more
doaj   +1 more source

Whole genome resequencing reveals an association of ABCC4 variants with preaxial polydactyly in pigs

BMC Genomics, 2020
Background Polydactyly is one of the most common congenital limb dysplasia in many animal species. Although preaxial polydactyly (PPD) has been comprehensively studied in humans as a common abnormality, the genetic variations in other animal species have
Cheng Ma, Saber Khederzadeh, Adeniyi C. Adeola, Xu-Man Han, Hai-Bing Xie, Ya-Ping Zhang   +5 more
doaj   +1 more source

Prognostic significance and molecular mechanism of ATP-binding cassette subfamily C member 4 in resistance to neoadjuvant radiotherapy of locally advanced rectal carcinoma.

PLoS ONE, 2014
BackgroundMechanism of radioresistance in rectal carcinoma remains largely unknown. We aimed to evaluate the predictive role of ATP-binding cassette subfamily C member 4 (ABCC4) in locally advanced rectal carcinoma and explore possible molecular ...
Zhiqi Yu, Chang Zhang, Rui Chai, Yan Du, Xianhua Gao, Junjie Xing, Enda Yu, Wei Zhang, Xiaoqing Zhang, Guangwen Cao, Chuangang Fu   +10 more
doaj   +1 more source