Results 21 to 30 of about 3,675 (154)

Association of ABCB1, ABCC4 and SLCO1B1 polymorphisms with high dose-MTX blood concentration and adverse events in childhood acute lymphoblastic leukemia [PDF]

Jichu yixue yu linchuang, 2022
Objective To investigate potential relationship between gene polymorphisms of ATP-binding cassette B1, C4 (ABCB1, ABCC4) and solute carrier organic anion transporter 1B1 gene(SLCO1B1) with methotrexate (MTX) blood drug concentration and high dose-MTX (HD-
TIAN Xiao-yi, LIU Ying, YAO Yao, GU Xiu-li, LI Ai-hua, ZHENG Hu-yong, SONG Wen-qi
doaj   +1 more source

The ABCC4 membrane transporter modulates platelet aggregation [PDF]

Blood, 2015
Key Points The ABC transporter, ABCC4, localizes to the platelet plasma membrane and regulates aggregation by exporting cAMP and antithrombotic drugs.
Satish B. Cheepala, Aaron Pitre, Yu Fukuda, Kazumasa Takenaka, Yuanyuan Zhang, Yao Wang, Sharon Frase, Tamara Pestina, T. Kent Gartner, Carl Jackson, John D. Schuetz   +10 more
openaire   +2 more sources

ABCC4 Is a Determinant of Cytarabine‐Induced Cytotoxicity and Myelosuppression [PDF]

Clinical and Translational Science, 2016
Resistance to cytarabine remains a major challenge in the treatment of acute myeloid leukemia (AML). Based on previous studies implicating ABCC4/MRP4 in the transport of nucleosides, we hypothesized that cytarabine is sensitive to ABCC4‐mediated efflux, thereby decreasing its cytotoxic response against AML blasts.
Drenberg, CD, Hu, S, Li, L, Buelow, DR, Orwick, SJ, Gibson, AA, Schuetz, JD, Sparreboom, A, Baker, SD   +8 more
openaire   +2 more sources

Clinical Significance and Potential Mechanisms of ATP Binding Cassette Subfamily C Genes in Hepatocellular Carcinoma

Frontiers in Genetics, 2022
The purpose of this investigation was to assess the diagnostic and prognostic significance of ATP binding cassette subfamily C (ABCC) genes in hepatocellular carcinoma (HCC).
Xin Zhou, Xin Zhou, Jia-mi Huang, Jia-mi Huang, Tian-man Li, Tian-man Li, Jun-qi Liu, Jun-qi Liu, Zhong-liu Wei, Zhong-liu Wei, Chen-lu Lan, Chen-lu Lan, Guang-zhi Zhu, Guang-zhi Zhu, Xi-wen Liao, Xi-wen Liao, Xin-ping Ye, Xin-ping Ye, Tao Peng, Tao Peng   +19 more
doaj   +1 more source

The Effect of ABCG2 and ABCC4 on the Pharmacokinetics of Methotrexate in the Brain [PDF]

Drug Metabolism and Disposition, 2014
Methotrexate (MTX) is the cornerstone of chemotherapy for primary central nervous system lymphoma, yet how the blood-brain barrier (BBB) efflux transporters ABCG2 and ABCC4 influence the required high-dose therapy is unknown. To evaluate their role, we used four mouse strains, C57BL/6 (wild-type; WT), Abcg2(-/-), Abcc4(-/-), and Abcg2(-/-);Abcc4 ...
Ramola, Sane, Shu-Pei, Wu, Rong, Zhang, James M, Gallo   +3 more
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1. [PDF]

FEBS Open Bio
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Singer D, Kragl A, Ziems K, Glaubitz J, Grammbauer S, Hildebrandt S, Tzvetkov MV, Jedlitschky G.   +7 more
europepmc   +2 more sources

Differential Selectivity of Human and Mouse ABCC4/Abcc4 for Arsenic Metabolites. [PDF]

Drug Metab Dispos
Millions of people globally are exposed to the proven human carcinogen arsenic at unacceptable levels in drinking water. In contrast, arsenic is a poor rodent carcinogen, requiring >100-fold higher doses for tumor induction, which may be explained by toxicokinetic differences between humans and mice.
Whitlock BD, Ma Y, Conseil G, O'Brien AR, Banerjee M, Swanlund DP, Lin ZP, Wang Y, Le XC, Schuetz JD, Cole SPC, Leslie EM.   +11 more
europepmc   +3 more sources

Increased ABCC4 Expression Induced by ERRα Leads to Docetaxel Resistance via Efflux of Docetaxel in Prostate Cancer

Frontiers in Oncology, 2020
Docetaxel is a major treatment for advanced prostate cancer (PCa); however, its resistance compromises clinical effectiveness. Estrogen receptor-related receptor alpha (ERRα) belongs to an orphan nuclear receptor superfamily and was recently found to be ...
Houbao Huang, Jing Li, Jing Shen, Jing Shen, Ling Lin, Ling Lin, Xu Wu, Xu Wu, Shixin Xiang, Shixin Xiang, Yawei Li, Yujie Xu, Qijie Zhao, Qijie Zhao, Yueshui Zhao, Yueshui Zhao, Parham Jabbarzadeh Kaboli, Parham Jabbarzadeh Kaboli, Mingxing Li, Mingxing Li, Xiang Li, Weiping Wang, Qinglian Wen, Zhangang Xiao, Zhangang Xiao   +24 more
doaj   +1 more source

Functional Expression of Multidrug Resistance Protein 4 MRP4/ABCC4 [PDF]

SLAS Discovery, 2019
To study the function and structure of membrane proteins, high quantities of pure and stable protein are needed. One of the first hurdles in accomplishing this is expression of the membrane protein at high levels and in a functional state. Membrane proteins are naturally expressed at low levels, so finding a suitable host for overexpression is ...
David Hardy, Roslyn M. Bill, Anass Jawhari, Alice J. Rothnie   +3 more
openaire   +3 more sources

Potentiation of long-acting β2-agonist and glucocorticoid responses in human airway epithelial cells by modulation of intracellular cAMP

Respiratory Research, 2021
Introduction Over 300 million people in the world live with asthma, resulting in 500,000 annual global deaths with future increases expected. It is estimated that around 50–80% of asthma exacerbations are due to viral infections. Currently, a combination
Yechan Kim, Vincent Hou, Ryan D. Huff, Jennifer A. Aguiar, Spencer Revill, Nicholas Tiessen, Quynh Cao, Matthew S. Miller, Mark D. Inman, Kjetil Ask, Andrew C. Doxey, Jeremy A. Hirota   +11 more
doaj   +1 more source