A Human ABC Transporter ABCC4 Gene SNP (rs11568658, 559 G > T, G187W) Reduces ABCC4-Dependent Drug Resistance [PDF]
Cells, 2019 Broad-spectrum drug resistance is a major obstacle in cancer treatment, which is often caused by overexpression of ABC transporters the levels of which vary between individuals due to single-nucleotide polymorphisms (SNPs) in their genes.
Megumi Tsukamoto +3 more
doaj +3 more sources
Characterization of zebrafish Abcc4 as an efflux transporter of organochlorine pesticides.
PLoS ONE, 2014 DDT and lindane are highly toxic organochlorine pesticides and posing adverse effects on the environment and public health due to their frequent usage in developing countries.
Xing Lu +5 more
doaj +4 more sources
A Role of the ABCC4 Gene Polymorphism in Airway Inflammation of Asthmatics [PDF]
Mediators of Inflammation, 2017 The ATP-binding cassette subfamily C member 4 gene encodes a transmembrane protein involved in the export of proinflammatory molecules, including leukotriene, prostaglandin, and sphingosine-1-phosphate across the plasma membrane.
Sailesh Palikhe +6 more
doaj +4 more sources
Transport of eicosapentaenoic acid-derived PGE₃, PGF(3α), and TXB₃ by ABCC4.
PLoS ONE, 2014 BackgroundEicosapentaenoic acid-derived prostaglandin (PG) E3, PGF(3α), and thromboxane (TX) B3 are bioactive lipid mediators which have anti-cancer and anti-inflammatory effects.
Nobuaki Tanaka +2 more
doaj +4 more sources
The ABCC4 gene is associated with pyometra in golden retriever dogs [PDF]
Scientific Reports, 2021 Pyometra is one of the most common diseases in female dogs, presenting as purulent inflammation and bacterial infection of the uterus. On average 20% of intact female dogs are affected before 10 years of age, a proportion that varies greatly between ...
Maja Arendt +11 more
doaj +7 more sources
Whole genome resequencing reveals an association of ABCC4 variants with preaxial polydactyly in pigs [PDF]
BMC Genomics, 2020 Background Polydactyly is one of the most common congenital limb dysplasia in many animal species. Although preaxial polydactyly (PPD) has been comprehensively studied in humans as a common abnormality, the genetic variations in other animal species have
Cheng Ma +5 more
doaj +3 more sources
Influence of Genetic Variation of GST, CYP, and ABC on the Safety and Efficacy of Cyclophosphamide‐Based Therapy [PDF]
Clinical and Translational ScienceCyclophosphamide (CTX) is one of the most widely used drugs in the clinical treatment of tumors and autoimmune diseases. The correlation between CYP, GST, and ABC gene polymorphisms and CTX activity and its induced toxicity has been extensively studied ...
Zhong‐Wei Yao +9 more
doaj +2 more sources
Knockdown of an ATP-binding cassette transporter in resistant western corn rootworm larvae partially reverses resistance to eCry3.1Ab protein [PDF]
Scientific ReportsThe western corn rootworm (WCR), Diabrotica virgifera virgifera LeConte, has evolved resistance to nearly every management tactic utilized in the field.
Adriano E. Pereira +8 more
doaj +2 more sources
Tonoplast-Localized ABCC Transporters Enhance Heterologous Production of the Antidiabetic Montbretin A and Its Analogues in Nicotiana benthamiana. [PDF]
Plant Biotechnol JABSTRACT The plant‐derived specialized metabolite montbretin A (MbA) is under development as an improved treatment for Type 2 diabetes, a worldwide epidemic. MbA is an acylated flavonol glycoside so far only found in small amounts in montbretia (Crocosmia × crocosmiiflora) corms.
Hijmans C +4 more
europepmc +2 more sources
Associations of Genetic Variants in Uric Acid Transporter Genes With Salt Sensitivity, Longitudinal Blood Pressure Changes, and Incident Hypertension in Chinese Adults. [PDF]
J Clin Hypertens (Greenwich)ABSTRACT Uric acid transporters mediate renal and extrarenal urate handling and may contribute to blood pressure (BP) regulation. This study examined the associations of common single‐nucleotide polymorphisms (SNPs) in key urate transporter genes (SLC2A9, ABCG2, SLC17A3, SLC22A7, SLC22A6, SLC22A11, SLC22A12, and ABCC4) with salt sensitivity ...
Chang MK +7 more
europepmc +2 more sources