Characterization of zebrafish Abcc4 as an efflux transporter of organochlorine pesticides.
PLoS ONE, 2014 DDT and lindane are highly toxic organochlorine pesticides and posing adverse effects on the environment and public health due to their frequent usage in developing countries.
Xing Lu +5 more
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Transport of eicosapentaenoic acid-derived PGE₃, PGF(3α), and TXB₃ by ABCC4.
PLoS ONE, 2014 BackgroundEicosapentaenoic acid-derived prostaglandin (PG) E3, PGF(3α), and thromboxane (TX) B3 are bioactive lipid mediators which have anti-cancer and anti-inflammatory effects.
Nobuaki Tanaka +2 more
doaj +2 more sources
PLoS ONE, 2011 Exposure of J774 mouse macrophages to stepwise increasing concentrations of ciprofloxacin, an antibiotic inhibiting bacterial topoisomerases, selects for resistant cells that overexpress the efflux transporter Abcc4 (Marquez et al.
Béatrice Marquez +5 more
doaj +3 more sources
Association of ABCB1, ABCC4 and SLCO1B1 polymorphisms with high dose-MTX blood concentration and adverse events in childhood acute lymphoblastic leukemia [PDF]
Jichu yixue yu linchuang, 2022 Objective To investigate potential relationship between gene polymorphisms of ATP-binding cassette B1, C4 (ABCB1, ABCC4) and solute carrier organic anion transporter 1B1 gene(SLCO1B1) with methotrexate (MTX) blood drug concentration and high dose-MTX (HD-
TIAN Xiao-yi, LIU Ying, YAO Yao, GU Xiu-li, LI Ai-hua, ZHENG Hu-yong, SONG Wen-qi
doaj +2 more sources
Transcriptomic insights into the mechanism of action of telomere-related biomarkers in rheumatoid arthritis [PDF]
Frontiers in ImmunologyBackgroundRheumatoid arthritis (RA) is an autoimmune inflammatory disease. The mechanism by which telomeres are involved in the development of RA remains unclear.
Lijuan Feng +4 more
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Influence of Genetic Variation of GST, CYP, and ABC on the Safety and Efficacy of Cyclophosphamide‐Based Therapy [PDF]
Clinical and Translational ScienceCyclophosphamide (CTX) is one of the most widely used drugs in the clinical treatment of tumors and autoimmune diseases. The correlation between CYP, GST, and ABC gene polymorphisms and CTX activity and its induced toxicity has been extensively studied ...
Zhong‐Wei Yao +9 more
doaj +2 more sources
Knockdown of an ATP-binding cassette transporter in resistant western corn rootworm larvae partially reverses resistance to eCry3.1Ab protein [PDF]
Scientific ReportsThe western corn rootworm (WCR), Diabrotica virgifera virgifera LeConte, has evolved resistance to nearly every management tactic utilized in the field.
Adriano E. Pereira +8 more
doaj +2 more sources
Molecular Therapy: Methods & Clinical Development, 2015 The ATP-binding cassette transporter MRP4 (encoded by ABCC4) regulates membrane cyclic nucleotides concentrations in arterial cells including smooth muscle cells.
Caroline Claude +8 more
doaj +2 more sources
Scientific Reports, 2017 To investigate the association of microRNA (miRNA) binding-site polymorphisms in the drug transporter genes with the efficacy of 5-Fluorouracil (5-FU)/capecitabine-based chemotherapy in colorectal cancer (CRC), 6 polymorphisms were determined in 432 CRC ...
Qi Chen +7 more
doaj +2 more sources
The Role of Candidate Polymorphisms in Drug Transporter Genes on High‐Dose Methotrexate in the Consolidation Phase of the AIEOP‐BFM ALL 2009 Protocol [PDF]
Clinical and Translational ScienceHigh‐dose methotrexate (HD‐MTX) infusions are commonly used to consolidate remission in children with acute lymphoblastic leukemia (ALL). We investigate the potential role of candidate polymorphisms in SLCO1B1 (rs4149056 and rs2306283), ABCB1 (rs1045642),
Stefania Braidotti +15 more
doaj +2 more sources