Results 1 to 10 of about 3,675 (154)

Structural basis of human ABCC4 recognition of cAMP and ligand recognition flexibility [PDF]

Cell and Bioscience
Background ABCC4 (ATP-binding cassette sub-family C member 4) is a transporter protein that is primarily localized to the plasma membrane, and its efflux activity is associated with the progression of various cancers and the development of drug ...
Minghui Li, Changyou Guo
exaly   +5 more sources

Protein Kinase A and assembly of an ABCC4 protein network [PDF]

Nature Communications
Cyclic AMP (cAMP) compartmentalization at the plasma membrane employs export by ABCC4, yet the protein machinery that creates spatially restricted signaling has remained unclear.
Jingwen Zhu, Sabina Ranjit, Tomoka Gose, Amanda Nourse, Vishwajeeth R. Pagala, Zuo-Fei Yuan, John Lynch, Yao Wang, Aaron Pitre, Rebecca Crawford, Junmin Peng, Juwina Wijaya, Anjaparavanda P. Naren, John D. Schuetz   +13 more
doaj   +5 more sources

Investigating the crosstalk between ABCC4 and ABCC5 in 3T3-L1 adipocyte differentiation [PDF]

Frontiers in Molecular Biosciences
IntroductionThe plasma membrane-bound protein, multi-drug resistance-associated protein 4 (MRP4/ABCC4), has gained attention for its pivotal role in facilitating the efflux of a wide range of endogenous and xenobiotic molecules.
Ankit P. Laddha, Aniket Wahane, Raman Bahal, José E. Manautou   +3 more
doaj   +4 more sources

Integrated SNP and SV Analyses Reveal Genetic Mechanisms Underlying High-Altitude Adaptation in Goats [PDF]

Animals
High-altitude environments, characterized by hypoxia, intense ultraviolet radiation, and low temperatures, pose major challenges to livestock survival.
Wenze Li, Yixin Su, Can Liu, Xiaokun Lin, Shanhui Xue, Bouabid Badaoui, Xiaochun Yan, Qi Lv, Rui Su   +8 more
doaj   +2 more sources

ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver [PDF]

Communications Biology
Low expression level of low-density lipoprotein receptor (LDLR) in hepatocytes leads to hypercholesterolemia and eventually contributes to atherosclerotic cardiovascular disease (ASCVD).
Jiaxin Chen, Hui Huang, Chi Chen, Guofang Xia, Hao Huang, Yan Xiong, Peng Luo, Yu Chen, Jinsong Li, Liang Wen, Lu Li, Jing Lin, Guangre Xu, Chenzhang Ji, Wenjie Tian, Jin Zhou, Peng Wei, Chengxing Shen, Xiaoqing Wang   +18 more
doaj   +2 more sources

Founder genetic variants of ABCC4 and ABCC11 in the Japanese population are not associated with the development of subacute myelo-optico-neuropathy (SMON)

Molecular Genetics & Genomic Medicine, 2022
Background Subacute myelo‐optico‐neuropathy (SMON) is a severe neurological disorder associated with clioquinol administration, which frequently occurred in Japan during the 1950s and 1960s.
Hideo Sasai, Masato Katsuyama, Hidenori Ohnishi   +2 more
exaly   +2 more sources

Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity

JACC Basic To Translational Science, 2018
An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy ...
Jeffrey S Berger, Tilla S Worgall, Adriana Heguy   +2 more
exaly   +3 more sources

Identification of Novel Biomarkers Associated with Corticosteroid Resistance in Asthma by Bioinformatics Analysis and Experimental Validation [PDF]

Journal of Inflammation Research
Lingling Xuan,* Lulu Ren,* Wen Zhang, Zhuoling An Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence ...
Xuan L, Ren L, Zhang W, An Z
doaj   +2 more sources

Genetic polymorphisms associated with therapeutic response and adverse effects to methotrexate in Taiwanese patients with rheumatoid arthritis: a real-world, hospital-based study [PDF]

Scientific Reports
Although methotrexate (MTX) is extensively utilized in management of rheumatoid arthritis (RA), its pharmacogenomics are still unclear. This study explores the genetic determinants impacting MTX’s effectiveness and adverse effects in Taiwanese patients ...
Ta-Wei Yu, I-Chieh Chen, Guan-Cheng Lin, Chung-Mao Kao, Yen-Ju Chen, Yi-Ming Chen   +5 more
doaj   +2 more sources

Transcriptomic insights into the mechanism of action of telomere-related biomarkers in rheumatoid arthritis [PDF]

Frontiers in Immunology
BackgroundRheumatoid arthritis (RA) is an autoimmune inflammatory disease. The mechanism by which telomeres are involved in the development of RA remains unclear.
Lijuan Feng, Kaiyong Bai, Limeng He, Hao Wang, Wei Zhang   +4 more
doaj   +2 more sources