Results 1 to 10 of about 3,523 (156)

The xenobiotic transporter ABCC4/MRP4 promotes epithelial mesenchymal transition in pancreatic cancer [PDF]

Frontiers in Pharmacology
The xenobiotic transporter ABCC4/MRP4 is highly expressed in pancreatic ductal adenocarcinoma (PDAC) and correlates with a more aggressive phenotype and metastatic propensity.
S. N. Gancedo, A. Sahores, A. Sahores, N. Gómez, N. Di Siervi, M. May, A. Yaneff, A. Yaneff, M. G. de Sousa Serro, N. Fraunhoffer, N. Fraunhoffer, N. Fraunhoffer, N. Dusetti, N. Dusetti, N. Dusetti, J. Iovanna, J. Iovanna, J. Iovanna, J. Iovanna, C. Shayo, C. A. Davio, C. A. Davio, B. González, B. González   +23 more
exaly   +7 more sources

A Human ABC Transporter ABCC4 Gene SNP (rs11568658, 559 G > T, G187W) Reduces ABCC4-Dependent Drug Resistance [PDF]

Cells, 2019
Broad-spectrum drug resistance is a major obstacle in cancer treatment, which is often caused by overexpression of ABC transporters the levels of which vary between individuals due to single-nucleotide polymorphisms (SNPs) in their genes.
Hiroshi Nakagawa
exaly   +6 more sources

Investigating the crosstalk between ABCC4 and ABCC5 in 3T3-L1 adipocyte differentiation [PDF]

Frontiers in Molecular Biosciences
IntroductionThe plasma membrane-bound protein, multi-drug resistance-associated protein 4 (MRP4/ABCC4), has gained attention for its pivotal role in facilitating the efflux of a wide range of endogenous and xenobiotic molecules.
Ankit P. Laddha, Aniket Wahane, Raman Bahal, José E. Manautou   +3 more
doaj   +4 more sources

Structural basis of human ABCC4 recognition of cAMP and ligand recognition flexibility [PDF]

Cell & Bioscience
Background ABCC4 (ATP-binding cassette sub-family C member 4) is a transporter protein that is primarily localized to the plasma membrane, and its efflux activity is associated with the progression of various cancers and the development of drug ...
Xuepeng Wen, Kaixue Si, Dantong Zhu, Anqi Zhang, Changyou Guo, Minghui Li, Weiming Tian   +6 more
doaj   +4 more sources

Protein Kinase A and assembly of an ABCC4 protein network [PDF]

Nature Communications
Cyclic AMP (cAMP) compartmentalization at the plasma membrane employs export by ABCC4, yet the protein machinery that creates spatially restricted signaling has remained unclear.
Jingwen Zhu, Sabina Ranjit, Tomoka Gose, Amanda Nourse, Vishwajeeth R. Pagala, Zuo-Fei Yuan, John Lynch, Yao Wang, Aaron Pitre, Rebecca Crawford, Junmin Peng, Juwina Wijaya, Anjaparavanda P. Naren, John D. Schuetz   +13 more
doaj   +2 more sources

Effects of cAMP and CFTR modulation on apical fluid pH in human airway Calu-3 cells. [PDF]

Physiol Rep
Abstract The airway epithelium serves as the first line of defense against inhaled insults present in the external environment by acting as a physical barrier and through host defense mechanisms. Proper maintenance of these host defense mechanisms relies on the regulation of airway surface liquid (ASL) composition and properties, a process that is ...
Nguyen JP, Milad N, Hirota JA.
europepmc   +2 more sources

ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver [PDF]

Communications Biology
Low expression level of low-density lipoprotein receptor (LDLR) in hepatocytes leads to hypercholesterolemia and eventually contributes to atherosclerotic cardiovascular disease (ASCVD).
Jiaxin Chen, Hui Huang, Chi Chen, Guofang Xia, Hao Huang, Yan Xiong, Peng Luo, Yu Chen, Jinsong Li, Liang Wen, Lu Li, Jing Lin, Guangre Xu, Chenzhang Ji, Wenjie Tian, Jin Zhou, Peng Wei, Chengxing Shen, Xiaoqing Wang   +18 more
doaj   +2 more sources

Increased ABCC4 Expression Induced by ERRα Leads to Docetaxel Resistance via Efflux of Docetaxel in Prostate Cancer

Frontiers in Oncology, 2020
Docetaxel is a major treatment for advanced prostate cancer (PCa); however, its resistance compromises clinical effectiveness. Estrogen receptor-related receptor alpha (ERRα) belongs to an orphan nuclear receptor superfamily and was recently found to be ...
Ling Lin, Xu Wu, Zhao Qijie
exaly   +3 more sources

Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity

JACC Basic To Translational Science, 2018
An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy ...
Michael Cammer, Tilla S Worgall, Adriana Heguy   +2 more
exaly   +3 more sources

Identification of Novel Biomarkers Associated with Corticosteroid Resistance in Asthma by Bioinformatics Analysis and Experimental Validation [PDF]

Journal of Inflammation Research
Lingling Xuan,* Lulu Ren,* Wen Zhang, Zhuoling An Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence ...
Xuan L, Ren L, Zhang W, An Z
doaj   +2 more sources