Results 31 to 40 of about 3,675 (154)

Postherpetic Neuralgia: Mechanisms, Risk Factors, and Stratified Management-A Narrative Review. [PDF]

CNS Neurosci Ther
The incidence of PHN is increasing, posing a substantial public health burden. Its pathogenesis involves VZV reactivation, peripheral and central sensitization, and genetic susceptibility, with key risk factors including older age, severe acute pain, extensive rash, immunocompromise, comorbidities, and delayed treatment.
Tang F, Zhao F.
europepmc   +2 more sources

Role of MRP4 (ABCC4) in Platelet Adenine Nucleotide-Storage [PDF]

The American Journal of Pathology, 2010
We previously showed that the MRP4 (ABCC4) transporter is expressed in human platelet delta-granules and may be involved in ADP transport. We now demonstrate by immunoblotting and immunofluorescence microscopy that platelet MRP4 is absent in two patients with a platelet delta-storage pool deficiency (delta-SPD)-like phenotype with reduced platelet ...
G. Jedlitschky, M. Cattaneo, L. E. Lubenow, D. Rosskopf, A. Lecchi, A. Artoni, G. Motta, J. Niessen, H. K. Kroemer, A. Greinacher   +9 more
openaire   +3 more sources

HOXA13, Negatively Regulated by miR-139-5p, Decreases the Sensitivity of Gastric Cancer to 5-Fluorouracil Possibly by Targeting ABCC4

Frontiers in Oncology, 2021
PurposeChemoresistance remains a major challenge in the therapy of gastric cancer (GC). The homeobox (HOX) gene family has gained attention in carcinogenesis and chemoresistance.
Zhengqian Chen, Zhengqian Chen, Zhiwei Qin, Lei Li, Qi Wo, Xia Chen   +5 more
doaj   +1 more source

Contribution of Abcc4-Mediated Gastric Transport to the Absorption and Efficacy of Dasatinib [PDF]

Clinical Cancer Research, 2013
Abstract Purpose: Several oral multikinase inhibitors are known to interact in vitro with the human ATP-binding cassette transporter ABCC4 (MRP4), but the in vivo relevance of this interaction remains poorly understood. We hypothesized that host ABCC4 activity may influence the pharmacokinetic profile of dasatinib and subsequently ...
Brian D, Furmanski, Shuiying, Hu, Ken-Ichi, Fujita, Lie, Li, Alice A, Gibson, Laura J, Janke, Richard T, Williams, John D, Schuetz, Alex, Sparreboom, Sharyn D, Baker   +9 more
openaire   +2 more sources

Prognostic significance and molecular mechanism of ATP-binding cassette subfamily C member 4 in resistance to neoadjuvant radiotherapy of locally advanced rectal carcinoma.

PLoS ONE, 2014
BackgroundMechanism of radioresistance in rectal carcinoma remains largely unknown. We aimed to evaluate the predictive role of ATP-binding cassette subfamily C member 4 (ABCC4) in locally advanced rectal carcinoma and explore possible molecular ...
Zhiqi Yu, Chang Zhang, Rui Chai, Yan Du, Xianhua Gao, Junjie Xing, Enda Yu, Wei Zhang, Xiaoqing Zhang, Guangwen Cao, Chuangang Fu   +10 more
doaj   +1 more source

Pharmacokinetics of Tenofovir Alafenamide Fumarate and Tenofovir in the Chinese People: Effects of Non-Genetic Factors and Genetic Variations

Pharmacogenomics and Personalized Medicine, 2021
Xue Li,1,* Xin-Yi Tan,2,* Xue-Jun Cui,3 Ming Yang,1 Chao Chen,1 Xiao-Yun Chen2 1Phase I Clinical Research Laboratory of Shanghai LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China ...
Li X, Tan XY, Cui XJ, Yang M, Chen C, Chen XY   +5 more
doaj  

Characterization of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacin.

PLoS ONE, 2011
Exposure of J774 mouse macrophages to stepwise increasing concentrations of ciprofloxacin, an antibiotic inhibiting bacterial topoisomerases, selects for resistant cells that overexpress the efflux transporter Abcc4 (Marquez et al.
Béatrice Marquez, Geneviève Ameye, Coralie M Vallet, Paul M Tulkens, Hélène A Poirel, Françoise Van Bambeke   +5 more
doaj   +1 more source

ABCC4 Variants Modify Susceptibility to Kawasaki Disease in a Southern Chinese Population [PDF]

Disease Markers, 2018
A previous family-based linkage study revealed that Kawasaki disease (KD) was associated with variations of the ATP-binding cassette subfamily C member 4 (ABCC4) gene in most European populations. However, significant differences exist among ethnic populations in European and Chinese subjects; therefore, whether ABCC4 variants indicate susceptibility ...
Di Che, Lei Pi, Zhenzhen Fang, Yufen Xu, Minmin Cai, Lanyan Fu, Huazhong Zhou, Li Zhang, Xiaoqiong Gu   +8 more
openaire   +2 more sources

Multidrug transporter MRP4/ABCC4 as a key determinant of pancreatic cancer aggressiveness [PDF]

Scientific Reports, 2020
AbstractRecent findings show that MRP4 is critical for pancreatic ductal adenocarcinoma (PDAC) cell proliferation. Nevertheless, the significance of MRP4 protein levels and function in PDAC progression is still unclear. The aim of this study was to determine the role of MRP4 in PDAC tumor aggressiveness. Bioinformatic studies revealed that PDAC samples
Ana Sahores, Alejandro Carozzo, María May, N. Gómez, Nicolás Di Siervi, M. De Sousa Serro, Agustín Yaneff, A. Rodrı́guez-González, Martı́n C. Abba, Carina Shayo, Carlos Davio   +10 more
openaire   +4 more sources

The Daily Expression of ABCC4 at the BCSFB Affects the Transport of Its Substrate Methotrexate [PDF]

International Journal of Molecular Sciences, 2022
The choroid plexuses (CPs), located in the brain ventricles, form an interface between the blood and the cerebrospinal fluid named the blood-cerebrospinal barrier, which, by the presence of tight junctions, detoxification enzymes, and membrane transporters, limits the traffic of molecules into the central nervous system.
André Furtado, Rafael Mineiro, Ana Catarina Duarte, Isabel Gonçalves, Cecília R. Santos, Telma Quintela   +5 more
openaire   +2 more sources