Results 31 to 40 of about 3,523 (156)

Characterization of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacin.

PLoS ONE, 2011
Exposure of J774 mouse macrophages to stepwise increasing concentrations of ciprofloxacin, an antibiotic inhibiting bacterial topoisomerases, selects for resistant cells that overexpress the efflux transporter Abcc4 (Marquez et al.
Béatrice Marquez, Geneviève Ameye, Coralie M Vallet, Paul M Tulkens, Hélène A Poirel, Françoise Van Bambeke   +5 more
doaj   +1 more source

Effect of polymorphisms in drug metabolism and transportation on plasma concentration of atorvastatin and its metabolites in patients with chronic kidney disease

Frontiers in Pharmacology, 2023
Dyslipidemia due to renal insufficiency is a common complication in patients with chronic kidney diseases (CKD), and a major risk factor for the development of cardiovascular events.
Zebin Jiang, Zemin Wu, Ruixue Liu, Qin Du, Xian Fu, Min Li, Yongjun Kuang, Shen Lin, Jiaxuan Wu, Weiji Xie, Ganggang Shi, Yanqiang Peng, Fuchun Zheng, Fuchun Zheng   +13 more
doaj   +1 more source

Go with the flow: ABCC4 mediates cytokinin efflux to control root development. [PDF]

Plant Physiol
Torres-Martínez HH.
europepmc   +3 more sources

Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons [PDF]

Human Molecular Genetics, 2003
Drug transporters are an important part of the defense of cells against cytotoxic agents. One major group of transporters is known as multidrug resistance associated proteins (MRP; ABCC gene family). The MRPs belong to the ATP binding cassette transporter superfamily. One family member, ABCC4 (also known as MRP4) functions as a cellular efflux pump for
Jatinder Kaur, Lamba, Masashi, Adachi, Daxi, Sun, Jaana, Tammur, Erin G, Schuetz, Rando, Allikmets, John D, Schuetz   +6 more
openaire   +2 more sources

Small extracellular vesicles secreted by vaginal fibroblasts exert inhibitory effect in female stress urinary incontinence through regulating the function of fibroblasts.

PLoS ONE, 2021
Stress urinary incontinence (SUI) is a common condition in women and associated with extra-cellular matrix (ECM) reconstruction, which is mainly regulated by fibroblasts. However, the underlying mechanism remains obscure.
Xiaoyan Sun, Huimin Zhu, Wenjuan Li, Li Zhao, Wenhua Li, Xiaoyong Li, Zhenwei Xie   +6 more
doaj   +1 more source

Pharmacokinetics of Tenofovir Alafenamide Fumarate and Tenofovir in the Chinese People: Effects of Non-Genetic Factors and Genetic Variations

Pharmacogenomics and Personalized Medicine, 2021
Xue Li,1,* Xin-Yi Tan,2,* Xue-Jun Cui,3 Ming Yang,1 Chao Chen,1 Xiao-Yun Chen2 1Phase I Clinical Research Laboratory of Shanghai LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China ...
Li X, Tan XY, Cui XJ, Yang M, Chen C, Chen XY   +5 more
doaj  

Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon population

Molecular Genetics & Genomic Medicine, 2021
Background Susceptibility to Chronic Myeloid Leukemia (CML) may be modulated by genetic variables. However, the majority of previous investigations have focused on genetically homogeneous populations, resulting in a lack of evidence on how genetic ...
Natasha Monte, Karla B. C. C. Pantoja, Juliana C. G. Rodrigues, Darlen C. deCarvalho, Tereza C. B. Azevedo, Esdras E. B. Pereira, Paulo P. deAssumpção, Sidney E. B. dosSantos, Marianne R. Fernandes, Ney P. C. dosSantos   +9 more
doaj   +1 more source

ABCC4/MRP4: a MYCN-regulated transporter and potential therapeutic target in neuroblastoma [PDF]

Frontiers in Oncology, 2012
Resistance to cytotoxic drugs is thought to be a major cause of treatment failure in childhood neuroblastoma, and members of the ATP-binding cassette (ABC) transporter superfamily may contribute to this phenomenon by active efflux of chemotherapeutic agents from cancer cells.
Huynh, Tony, Norris, Murray D, Haber, Michelle, Henderson, Michelle J   +3 more
openaire   +4 more sources

Variants in TPMT, ITPA, ABCC4 and ABCB1 genes as predictors of 6-mercaptopurine induced toxicity in children with acute lymphoblastic leukemia [PDF]

Journal of Medical Biochemistry, 2018
Background: Acute lymphoblastic leukemia is the most common childhood malignancy. Optimal use of anti leukemic drugs has led to less toxicity and adverse reactions, and a higher survival rate. Thiopurine drugs, including 6-mercaptopurine, are mostly used
Milošević Goran, Kotur Nikola, Krstovski Nada, Lazić Jelena, Zukić Branka, Stanković Biljana, Janić Dragana, Katsila Theodora, Patrinos George P., Pavlović Sonja, Dokmanović Lidija   +10 more
doaj  

MRP4 (ABCC4) as a potential pharmacologic target for cardiovascular disease

Pharmacological Research, 2016
This review focuses on multidrug resistance protein 4 (MRP4 or ABCC4) that has recently been shown to play a role in cAMP homeostasis, a key-pathway in vascular biology and in platelet functions. In vascular system, recent data provide evidence that inhibition of MRP4 prevents human coronary artery smooth muscle cell proliferation in vitro and in vivo,
Tiphaine, Belleville-Rolland, Yassine, Sassi, Benoit, Decouture, Elise, Dreano, Jean-Sébastien, Hulot, Pascale, Gaussem, Christilla, Bachelot-Loza   +6 more
openaire   +2 more sources