Results 51 to 60 of about 3,675 (154)

Go with the flow: ABCC4 mediates cytokinin efflux to control root development. [PDF]

Plant Physiol
Torres-Martínez HH.
europepmc   +3 more sources

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Clinical and genetic factors associated with kidney tubular dysfunction in a real-life single centre cohort of HIV-positive patients

BMC Infectious Diseases, 2017
Background Tenofovir (TDF) is one of the most widely used antiretroviral drug. Despite the high degree of tolerability a small percentage of patients experienced alteration in tubular function during TDF use. Intracellular TDF disposition is regulated by
S. E. Salvaggio, A. Giacomelli, F. S. Falvella, M. L. Oreni, P. Meraviglia, C. Atzori, E. G. I. Clementi, M. Galli, S. Rusconi   +8 more
doaj   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

Inhalable delivery of AAV-based MRP4/ABCC4 silencing RNA prevents monocrotaline-induced pulmonary hypertension

Molecular Therapy: Methods & Clinical Development, 2015
The ATP-binding cassette transporter MRP4 (encoded by ABCC4) regulates membrane cyclic nucleotides concentrations in arterial cells including smooth muscle cells.
Caroline Claude, Nathalie Mougenot, Julia Bechaux, Lahouaria Hadri, Damian Brockschnieder, Michel Clergue, Fabrice Atassi, Anne-Marie Lompré, Jean-Sébastien Hulot   +8 more
doaj   +1 more source

PGE2 Enhances Human ILC3 Function but Constrains ILC2‐to‐ILC3 Plasticity

European Journal of Immunology, Volume 56, Issue 10, October 2026.
Distinct prostaglandin circuits regulate human ILC2 and ILC3 function. ILC3‐derived PGE2 promotes type 3 cytokine production, whereas hybrid ILC2/3 generated during plasticity retain an inhibitory response to PGE2 despite acquiring ILC3‐like features. ABSTRACT Type 2 innate lymphoid cells (ILC2) drive eosinophilic asthma, whereas ILC3 and plastic ILC2 ...
Lorenz Wirth, Whitney Weigel, Efthymia Kokkinou, Johan Kolmert, Anna‐Karin Johnsson, Alessandro Quaranta, Craig Wheelock, Mattias Jangard, Ram V. Pandey, Sven‐Erik Dahlén, Christopher Andrew Tibbitt, Thomas Hochdörfer, Jenny Mjösberg   +12 more
wiley   +1 more source

Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma [PDF]

BioMed Research International, 2013
Ovarian cancer is the main cause of death from gynaecological malignancies. In spite of the efficacy of platinum-paclitaxel treatment in patients with primary epithelial ovarian carcinoma, platinum-based chemotherapy is not curative and resistance remains one of the most important causes of treatment failure.
M. Bagnoli, G. L. Beretta, L. Gatti, S. Pilotti, P. Alberti, E. Tarantino, M. Barbareschi, S. Canevari, D. Mezzanzanica, P. Perego   +9 more
openaire   +3 more sources

Enrichment and Proteomic Profiling of Stromal‐Associated Extracellular Vesicle Subpopulations From Arthritic Synovial Fluid by Size‐Exclusion Chromatography Coupled to CD90‐Directed Immunocapture

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Synovial fluid contains heterogeneous EV populations reflecting stromal and immune‐associated cellular inputs from the arthritic joint. SEC‐UF enrichment coupled to CD90‐targeted immunocapture enables recovery of stromal‐associated EV subpopulation from complex patient synovial fluid, while focused LC‐MS/MS and cell‐of‐origin analysis enable molecular ...
Stefanie Kurth, Edveena Hanser, Simone Häner‐Massimi, Stavros Giaglis, Florian Geier, Dominik Burri, Katarzyna Buczak, Ute Heider, Stefan Wild, Yves P. Acklin, Christian Egloff, André N. Tiaden, Diego Kyburz   +12 more
wiley   +1 more source

Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola

Insect Molecular Biology, Volume 35, Issue 5, Page 576-593, October 2026.
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño   +1 more
wiley   +1 more source

Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cells

Scientific Reports, 2021
Cystic fibrosis (CF) is a genetic disease characterized by CF transmembrane regulator (CFTR) dysfunction. With over 2000 CFTR variants identified, in addition to known patient to patient variability, there is a need for personalized treatment.
Jenny P. Nguyen, Matthew Bianca, Ryan D. Huff, Nicholas Tiessen, Mark D. Inman, Jeremy A. Hirota   +5 more
doaj   +1 more source