Results 91 to 100 of about 4,110 (154)

Supplementary Figure 3 from Contribution of Abcc4-Mediated Gastric Transport to the Absorption and Efficacy of Dasatinib

, 2013
PDF file - 399K, Influence of Abcc4 function on dasatinib disposition.
Shuiying Hu (10268480), Ken-ichi Fujita (83343), John D. Schuetz (11127821), Alice A. Gibson (10268477), Alex Sparreboom (236030), Lie Li (372905), Laura J. Janke (7498184), Brian D. Furmanski (14989523), Sharyn D. Baker (14918718), Richard T. Williams (14917794)   +9 more
core   +1 more source

Comparing ATPase activity of ATP-binding cassette subfamily C member 4, lamprey CFTR, and human CFTR using an antimony-phosphomolybdate assay

Frontiers in Pharmacology
Introduction: ATP-binding cassette (ABC) transporters use the hydrolysis of ATP to power the active transport of molecules, but paradoxically the cystic fibrosis transmembrane regulator (CFTR, ABCC7) forms an ion channel.
Guiying Cui, Kerry M. Strickland, Analia J. Vazquez Cegla, Nael A. McCarty   +3 more
doaj   +1 more source

Identification of associated single nucleotide polymorphism markers for early prediction of pyometra in companion dogs

Journal of Animal Reproduction and Biotechnology
Background: Pyometra, involves pus accumulation that can lead to death if detected late, making early diagnosis and management crucial, and it is more common in older dogs.
Seo Young Bae, Gwang Hyeon Lee, Hong Sik Kong   +2 more
doaj   +1 more source

cAMP regulates expression of the cyclic nucleotide transporter MRP4 (ABCC4) through the EPAC pathway

, 2014
Multidrug resistance protein 4 (MRP4/ABCC4) has been established as an independent regulator of cyclic AMP (cAMP) levels particularly in vascular smooth muscle cells and in hematopoietic cells. Here, we assessed whether cAMP in turn regulates MRP4.
Broderdorf, Susanne, Kroemer, Heyo K., Zang, Sebastian, Jedlitschky, Gabriele, Grube, Markus, Schaletzki, Yvonne   +5 more
core   +1 more source

ATP-binding cassette subfamily C (ABCC) transporter 1 (ABCC1) and 4 (ABCC4) independent of their drug efflux ability affects breast cancer biology [PDF]

Breast cancer treatment has been a challenge to date, due in part to cancer cells acquiring drug resistance. One of the mechanisms by which resistance can occur is the overexpression of drug efflux pumps such as ATP-binding cassette, subfamily C (ABCC ...
Low, Floren
core  

Inhibition of ABCC4-mediated 3-series prostanoids transport.

, 2014
Membrane vesicles (25 µg) from HEK293 or HEK293/4.63 cells were incubated with PGE3 (1 µM), PGF3α (2.5 µM), or TXB3 (2.5 µM) at 37°C. Rates of ATP-dependent transport were calculated by subtracting the uptake in the presence of AMP from that in the ...
Hiroaki Yamaguchi (440141), Nariyasu Mano (638428), Nobuaki Tanaka (638427)   +2 more
core   +1 more source

DS_DISC867074 – Supplemental material for Stabilization of Human Multidrug Resistance Protein 4 (MRP4/ABCC4) Using Novel Solubilization Agents

, 2019
Supplemental material, DS_DISC867074 for Stabilization of Human Multidrug Resistance Protein 4 (MRP4/ABCC4) Using Novel Solubilization Agents by David Hardy, Roslyn Bill, Alice Rothnie and Anass Jawhari in SLAS ...
Alice J. Rothnie (7139039), Anass Jawhari (6458423), David Hardy (848279), Roslyn M. Bill (308029)   +3 more
core   +1 more source

ABCC4 rs3741206基因对慢性肾病患者阿托伐他汀代谢及降脂效果的影响

Zhongguo shiyan zhenduanxue
目的 探讨ATP结合盒转运蛋白C4 rs3741206基因型对慢性肾病患者阿托伐他汀代谢及降脂效果的影响。方法 选取2022年1月至2023年6月期间江苏大学附属医院收治的120例慢性肾病患者作为研究对象，所有患者均给予阿托伐他汀(20 mg/d)治疗；患者在接受治疗6周后利用UPLC-MS/MS测定血浆阿托伐他汀(AT)及其代谢产物水平；检测患者ABCC4 rs3741206基因型并比较不同基因型患者AT及其代谢产物水平、血脂控制情况、不良反应等差异。结果 ABCC4 rs3741206包含AA、AC、
鲁雨辰
doaj  

Pharmacological evaluation of an ex vivo cervicovaginal HIV prevention model. [PDF]

J Antimicrob Chemother
Collins LB, Le A, Nicol MR.
europepmc   +1 more source

IsoProDB: an integrated map of human protein isoforms for accelerated research. [PDF]

Database (Oxford)
Soman SP, Ummar S, Ahmed M, Shivamurthy PB, Sreelan S, Ramesh P, Nisar M, Subbannayya Y, Raju R.   +8 more
europepmc   +1 more source